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2008 Fiscal Year Final Research Report

Schistosomiasis japonica : a re-emerging disease in China and a new approach for disease monitoring and effective control

Research Project

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Project/Area Number 18406012
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Parasitology (including Sanitary zoology)
Research InstitutionTokyo Medical and Dental University

Principal Investigator

OTA Nobuo  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (10143611)

Co-Investigator(Renkei-kenkyūsha) KUMAGAI Takashi  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (40369054)
NIHEI Naoko  国立感染症研究所, 客員研究員 (70425677)
Research Collaborator WEN Liyong  中国浙江省医学アカデミー, 寄生虫病研究所, 所長
LU Shaohong  中国浙江省医学アカデミー, 寄生虫病研究所, 副所長
WAN Tianping  中国安徽省・寄生虫病研究所, 所長
Project Period (FY) 2006 – 2008
Keywords日本住血吸虫 / 再興感染症 / DNA診断 / Oncomelania / LAMP法 / PCR
Research Abstract

中国における日本住血吸虫症流行地が低下してきている状況に応じて、中間宿主及び終宿主の感染を簡便で効率的な遺伝子検出によって評価するシステムを構築し、中間宿主貝の生態分布の地理生物学的なモニター、及び中間宿主貝と寄生虫の地理分布による適応の差異に関する情報も併せてリスクマップの作製を進め、流行状況が急速に変化してきている中国国内の日本住血吸虫症流行に対する新規対策スキームの開発と応用の可能性を中国との共同研究として実施した。

  • Research Products

    (18 results)

All 2009 2008 2007 2006

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (8 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Peroxiredoxin-1 from Schistosoma japonicum functions as a scavenger against hydrogen peroxide but no for nitric oxide2009

    • Author(s)
      Kumagai T, Osada Y, Ohta N, Kanazawa T.
    • Journal Title

      Molecular and Biochemical Parasitology 164

      Pages: 26-31

    • Peer Reviewed
  • [Journal Article] Spacial analysis and remote sensing for monitoring systems of Oncomelania nosophora following the eradication of schistosomiasis japonica in Yamanashi Prefecture2009

    • Author(s)
      Nihei N, Komagata O, Kobayashi M, Saitoh Y, Mochizuki K, Nakamura S.
    • Journal Title

      Journal of Infectious Diseases 19

      Pages: 125-132

    • Peer Reviewed
  • [Journal Article] Schistosoma mansoni infection reduces severity of collagen-induced arthritis via down-regulation of pro-inflammatory mediators2009

    • Author(s)
      Osada Y, Shimizu S, Kumagai T, Yamada S, Kanazawa T
    • Journal Title

      International Journal for Parasitology 39

      Pages: 457-464

    • Peer Reviewed
  • [Journal Article] A win-win collaboration to combat neglected tropical diseases in Southeast Asia2009

    • Author(s)
      Zhou XN, Ohta N, Utzinger J, Berquist R,Olveda RM. RNAS(+)
    • Journal Title

      Parasityology International 57

      Pages: 243-245

    • Peer Reviewed
  • [Journal Article] 国内問題としてのNeglected diseases2008

    • Author(s)
      太田伸生
    • Journal Title

      Clinical Parasitology 19

      Pages: 17-20

  • [Journal Article] Disease burden and epidemiology of soil-transmitted helminthiases and schistosomiasis in Asia : the Japanese perspective2007

    • Author(s)
      Ohta N, Waikagul J
    • Journal Title

      Trends in Parasitology 23

      Pages: 30-35

    • Peer Reviewed
  • [Journal Article] School-health-based parasite control initiatives : extending successful Japanese policies to Asia and Africa2007

    • Author(s)
      Kojima S, Aoki Y, Ohta N, Tateno S, Takeuchi T
    • Journal Title

      Trends in Parasitology 23

      Pages: 54-57

    • Peer Reviewed
  • [Journal Article] Evaluation of the antihelmintic effects of artesunate against experimental Schistosoma mansoni infection in mice using different treatment protocols2006

    • Author(s)
      Lu SH, Kumagai T, Ai QH, Yan XL, Ohmae H, Yabu Y, Li SW, Wen LY, Maruyama H, Ohta N
    • Journal Title

      Parasitology International 55

      Pages: 63-68

    • Peer Reviewed
  • [Presentation] Therapeutic effects of a synthesized compound on schistosomiasis mansoni : two different effects on worm killing and anti-fecundity in murine experimental infection2008

    • Author(s)
      Ohta N, Taniguchi T, Kumagai T,Shimogawara R, Kim HS, Wataya Y
    • Organizer
      17^<th> International Congress of Tropical Medicine and Malaria
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      20081000
  • [Presentation] A win-win collaboration to combat neglected tropical diseases in Southeast Asia2008

    • Author(s)
      Zhou XN, Ohta N, Ultzinger J, Berquist R, Olveda RM. RNAS(+)
    • Organizer
      17th International Congress of Tropical Medicine and Malaria
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      20081000
  • [Presentation] The comparison of susceptibility of Schistosoma japonicum Yamanashi strain against Oncomelania spp2008

    • Author(s)
      Shimogawara R, Kumagai T, Itagaki A, Nihei N, Saito Y, Ohta N.
    • Organizer
      from various areas
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      20081000
  • [Presentation] Direct gene suppression of peroxiredoxins from Schistosoma japonicum in the portal vein by in vivo RNA interference2008

    • Author(s)
      Kumagai T, Shimogawara R, Osada Y,Kanazawa T, Ohta N
    • Organizer
      from various areas
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      20081000
  • [Presentation] Surveillance for schistosomiasis after the interruption of transmission in Japan2008

    • Author(s)
      Ohta N
    • Organizer
      WHO Meeting on Schistosomiasis Control 2008
    • Place of Presentation
      Salvador, Brasil
    • Year and Date
      20080800
  • [Presentation] New compound of anti-schistosomal effects Searching a new tool for disease control2007

    • Author(s)
      Ohta N.
    • Organizer
      2^<nd> Nagasaki Symposium on Tropical and Emerging Infectious Diseases
    • Place of Presentation
      Nagasaki, Japan
    • Year and Date
      20071100
  • [Presentation] Epidemiological analysis of infectious diseases and the establishment of a surveillance system hrough remote sensing using ALOS images2007

    • Author(s)
      Nihei N
    • Organizer
      1^<st> Joint PI Symposium of ALOS Data Nodes for ALOS Science Program
    • Place of Presentation
      Kyoto
    • Year and Date
      20071100
  • [Presentation] 日本住血吸虫DNA検出を応用したミヤイリガイ感染率判定法の開発2007

    • Author(s)
      熊谷貴、下河原理江子、板橋明子、谷口斎恵、Wang T、Lu S、Wen L、太田伸生
    • Organizer
      第48回日本熱帯医学会
    • Place of Presentation
      別府
    • Year and Date
      20071000
  • [Book] 感染症と生態防御、分担執筆2008

    • Author(s)
      太田伸生
    • Total Pages
      東京
    • Publisher
      NHK出版
  • [Patent(Industrial Property Rights)] 新規抗住血吸虫剤2008

    • Inventor(s)
      綿矢有佑、金恵淑、平本晃子、佐藤聡、太田伸生、熊谷貴、下河原理江子、谷口斎恵
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Number
      100088904
    • Filing Date
      2008-07-01

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Published: 2010-06-10   Modified: 2016-04-21  

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