2007 Fiscal Year Final Research Report Summary
Immunogenetic analysis of the resistance to infectious diseases
| Project/Area Number |
18406019
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Immunology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TSUBATA Takeshi Tokyo Medical and Dental University, Laboratory of Immunology, School of Biomedical Science, Professor (80197756)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Kozo Laboratory of Immunology, Medical Research Institute, 難治疾患研究所, Assistant Professor (20376718)
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| Project Period (FY) |
2006 – 2007
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| Keywords | SARS / polymorphism / CD22 / CD72 / B lymphocyte / infectious diseases / alternative splicing / ER stress |
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| Research Abstract |
Both CD22 and CD72 are B lymphocyte membrane molecules that negatively regulate signaling thorough B cell antigen receptor. Both CD22 and CD72 genes are polymorphic. To elucidate whether polymorphisms of these genes are associated with resistance to acute infection, we examined haplotypes of both CD22 and CD72 in SARS patients in China and individuals who were close contact with SARS patients but did not develop SARS. A CD72 haplotype was tend to be increased in patients with severe symptoms although the increase was not significant because of the limited sample numbers. Next, we examined the functional difference of different CD72 haplotypes. The human CD72 gene generates two distinct splicing isoforms, i.e., full length CD72 and CD72 lacking exon 8 (CD72 Δ ex8). We demonstrated that the level of CD72 Δ ex8 but not full length CD72 depends on CD72 haoplotypes. Moreover, CD72 Δ ex8 is accumulated in the endoplastic reticulum (ER), and augments ER stress and apoptosis mediated by ER stress. These results indicate that CD72 polymorphism regulates expression of CD72 Δ ex8 that regulates B lymphocyte apoptosis mediated by ER stress, thereby regulating infection immunity.
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Research Products
(62 results)
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[Journal Article] Design, synthesis, and structure-activity relationships of novel series of sialosides as CD22specific inhibitors.2008
Author(s)
Abdu-Allah, H. H. M., Tamanaka, T., Yu, J., Lu, Z., Sadagopan, M., Adachi. T., Tsubata, T., Kelm, S., Ishida, H., Kiso, M.
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Journal Title
J. Me. l Chem. 51
Pages: 6665-6681
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The centromerio interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD. CD72b coneenic mice.2008
Author(s)
Hou, R., Ohtsuji, M., Ohtsuji, N., Zhang, L., Adachi, T., Hirose, S., Tsubata, T.
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Journal Title
Biochem. Biophys. Res. Comm. 380
Pages: 193-197
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts.2007
Author(s)
Yu, J., Sawada, T., Adachi, T., Gao, X., Takematsu, H., Kozutsumi, Y., Ishida, H., Kiso, M., Tsubata, T.
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Journal Title
Biochem. Biophys. Res. Commun. 360
Pages: 759-764
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Design, synthesis, and structure-activity relationships of novel series of sialosides as CD22-specific inhibitors.2007
Author(s)
Abdu-Allah, H. H. M., Tamanaka, T., Yu' J., Lu, Z., Sadagopan, M., Adachi. T., Tsubata, T., Kelm, S., Ishida, H., Kiso, M.
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Journal Title
J. Me. l Chem. 51
Pages: 6665-6681
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Ligation of tumor-produced mucins to CD22 dramatically impairs splenic marginal zone B cells.2007
Author(s)
Toda, M., Hisano, R., Yurugi, H., Akita, K., Maruyama, K., Inoue, M., Adachi, T., Tsubata, T., Nakada, H.
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Journal Title
Biochem J. 417
Pages: 673-683
Description
「研究成果報告書概要(和文)」より
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[Journal Article] The centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD. CD 72^b congenic mice.2007
Author(s)
Hou, R., Ohtsuji, M., Ohtsuji, N., Zhang, L., Adachi, T., Hirose, S., Tsubata, T.
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Journal Title
Biochem. Biophys. Res. Comm. 380
Pages: 193-197
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Synthetic glycan ligand excludes CD22 from2007
Author(s)
Yu, J., Sawada, T., Adachi, T., Gao, X., Takematsu, H., Kozutsumi, Y., Ishida, H., kiso, M., Tsubata, T.
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Journal Title
Biochem. Biophys. Res. Commun. 360
Pages: 759-764
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Bispecific Abs against modified protein and DNA with oxidized2006
Author(s)
Akagawa, M., Ito, S., Toyoda, K., Ishii, Y., Tatsuda, E., Shibata, T., Yatnaguchi, S., Kawai, Y., Ishino, K., Kishi, Y., Adachi, T., Tsubata, T., Takasaki, Y., Hattori, N., Matsuda, T., Uchida, K.
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Journal Title
PNAS 103
Pages: 6160-6165
Description
「研究成果報告書概要(欧文)」より
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[Presentation] CD22阻害化合物の構造活性相関2008
Author(s)
玉中大智, Hajjaj H. M. Abdu-Allah, Jie Yu, Lu Zhuoyuan, Magesh Sadagopan, 安達貴弘, 鍔田武志, Soerge Kelm, 石田秀治, 木曾眞
Organizer
第38回日本免疫学会総会・学術集会
Place of Presentation
京都
Year and Date
20081201-20081203
Description
「研究成果報告書概要(和文)」より
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[Presentation] The alternatively s pliced isoform of human CD72 that confers resistance against systemic lupus erythematosus regulats B lymphocyte apoptosis.2007
Author(s)
Hitomi, Y., Adachi, T., Tsuchiya, N., Honda, Z., Tokunaga, K., Tsubata, T.
Organizer
第37回日本免疫学会総会・学術集会
Place of Presentation
東京
Year and Date
20071120-20071122
Description
「研究成果報告書概要(和文)」より
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[Presentation] Design and synthesis of novel sialosides as potential CD22-specific inhibitors.2007
Author(s)
Mohamed, A, A, H, H., Tsubata, T., Ishida, H., Kiso, M.
Organizer
XIX International Symposium on Glycoconjugates.
Place of Presentation
Cairns, Australia.
Year and Date
20070715-20070720
Description
「研究成果報告書概要(和文)」より
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[Presentation] Design and synthesis of novel sialosides at : potential CD22-specific inhihibitors.2007
Author(s)
Mohamed, A, A, H, H., Tsubata, T., Ishida, H., Kiso, M.
Organizer
XIX International Symposium on Glycoconjugates. (Glyco-19)
Place of Presentation
Cairns, Australia.
Year and Date
20070715-20070720
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Design and synthesis of novel sialosides as potential CD22-specific inhibitors.2007
Author(s)
A, A, H, H, Mohamed., Tsubata, T., Ishida, H., Kiso, M.
Organizer
The 2nd Annual meeting of Japanese society for chemical biology
Place of Presentation
京都
Year and Date
20070509-20070510
Description
「研究成果報告書概要(和文)」より
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[Presentation] 糖鎖リガンド類似化合物によるBリンパ球活性化制御分子CD22の機能制御2007
Author(s)
Yu, J., Sawada, T., Adachi, T., Gao, X., Takematsu, H., Kozutsumi, Y., Ishida, H., Kiso, M., Tsubata, T.
Organizer
日本ケミカルバイオロジー研究会第2回年会
Place of Presentation
京都
Year and Date
20070509-20070510
Description
「研究成果報告書概要(和文)」より
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[Presentation] Bリンパ球の生と死2007
Author(s)
鍔田武志
Organizer
橋本康弘教授就任講演会
Place of Presentation
福島
Year and Date
2007-10-20
Description
「研究成果報告書概要(和文)」より
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[Presentation] Immunosuppressive effect of mucin on2006
Author(s)
Toda M, Takeuchi N, Inoue M, Adachi T, Matsubara J, Taketani S, Tsubata T, Murata T, Nakada H.
Organizer
20th IUBMB International Congless of Biochemistry and Molecular Biology and 11th FAOBMB Congress.
Place of Presentation
Kyoto, japan
Year and Date
20060618-20060623
Description
「研究成果報告書概要(欧文)」より
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