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2008 Fiscal Year Self-evaluation Report

International study on the prevalence of viral infection in myopcardial diseases

Research Project

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Project/Area Number 18406029
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Circulatory organs internal medicine
Research InstitutionKyoto University

Principal Investigator

MATSUMORI Akira  Kyoto University, 医学研究科, 准教授 (70135573)

Project Period (FY) 2006 – 2009
Keywordsウイルス / 心筋炎 / 心筋症 / 心不全 / C型肝炎ウイルス
Research Abstract

最近、われわれは1985~1990年米国を中心に実施された心筋炎の免疫抑制療法臨床試験のため登録された症例を解析し、1355例中59例(4.4%)がHCV感染が陽性であることが明らかになり、米国のHCV感染陽性率1.8%と比し有意に頻度が高いことが明らかとなった。
さらに、コクサッキ-ウイルス感染においても持続感染をきたすことが示され、ヒトにおいてこれらのゲノムが検出されるかが注目されている。本研究では心筋症・心不全におけるウイルス感染の有意を明らかにするため国際共同研究を実施し、その治療・予防法を確立することを目的とした。

  • Research Products

    (8 results)

All 2009 2008 2007 2006

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Anti-inflammatory effects of eplerenone on viral myocarditis2009

    • Author(s)
      Xiao J, et.al.
    • Journal Title

      Eur J Heart Fail 11(4)

      Pages: 349-53

    • Peer Reviewed
  • [Journal Article] HLA-DPss chain may confer the susceptibility to hepatitis C virus-associated hypertrophic cardiomyopathy2008

    • Author(s)
      Shichi D, Matsumori A, et.al.
    • Journal Title

      Int J Immunogegnet 35(1)

      Pages: 37-43

    • Peer Reviewed
  • [Journal Article] Mast cell play a critical role in the pathogenesis of viral myocarditis2008

    • Author(s)
      Higuchi H
    • Journal Title

      Circulation 118

      Pages: 363-372

    • Peer Reviewed
  • [Presentation] Joint Session of the Japanese Circulation Society and the American College of Cardiology : Unusual Cardiomyopathies2009

    • Author(s)
      Matsumori A
    • Organizer
      58^<th> Annual Scientific Session, American College of Cardiology
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2009-03-31
  • [Presentation] New classification of cardiomyopathies2008

    • Author(s)
      Matsumori A.
    • Organizer
      The 4^<th> China-Japan Cardiovascular Forum
    • Place of Presentation
      Beijing, China
    • Year and Date
      20081023-24
  • [Presentation] New Biomarkers : Free immunoglobulin light chains and Anti-troponin I antibodies : Japanese perspective. AHA/Japanese Circulation Society Joint Symposium: Cardiac Risk Prediction with Biomarkers: US and Japanese Populations2008

    • Author(s)
      Matsumori A.
    • Organizer
      Scientific sessions, American Heart Association
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2008-11-11
  • [Book] Dilated cardiomyopathy : A spectrum of conditions linking to viral myocarditis and cardiac remodeling cardiac remodeling(In Cardiomyopathy update)(Elsevier Japan, Tokyo)2007

    • Author(s)
      Liu PP, Matsumori A.
    • Total Pages
      79-110
    • Publisher
      Ed by Kawai C, Doi Y, McKenna WJ, Liu PP, Matsumori A.
  • [Patent(Industrial Property Rights)] 心疾患及びウイルス性疾患治療薬2006

    • Inventor(s)
      松森昭
    • Industrial Property Rights Holder
      松森昭
    • Industrial Property Number
      PCT/JP2006/316419
    • Filing Date
      2006-08-22

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Published: 2010-06-11   Modified: 2016-04-21  

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