Clinical study concerning the relationship between community-acquiredpneumonia and influenza in Thailand

2008 Fiscal Year Final Research Report

• Project/Area Number: 18406030
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Respiratory organ internal medicine
• Research Institution: Kurume University
• Principal Investigator: WATANABE Hiroshi Kurume University, 医学部, 教授 (90295080)
• Co-Investigator(Kenkyū-buntansha): HAMADA Nobuyuki 久留米大学, 医学部, 准教授 (00148793) ; HARA Koyu 久留米大学, 医学部, 講師 (40309753) ; WATANABE Kiwao 長崎大学, 熱帯医学研究所, 助手 (20220874)
• Project Period (FY): 2006 – 2008
• Keywords: 市中肺炎 / インフルエンザ / タイ

Research Abstract

2006-2008年度の間、タイ、チェンマイの市中病院であるナコンピン病院において入院加療を行った市中肺炎症例のうち、インフォームドコンセントの得られた119例(平均年齢55.0歳)を対象とし以下の検討を行った。119例中29例はHIV感染者 (平均CD4値148.9)で、90例は非HIV感染者 (平均CD4値527.4)であった。血液培養ではHIV感染者でCryptococcus neoformansとPenicillium marneffeiがそれぞれ2例から分離され、非HIV感染者でP. marneffeiが5例、Acinetobacter baumanniiとBurkholideria pseudomalleiがそれぞれ1例から分離された。喀痰ではPsedomonas aeruginosa, Haemophilus influenzae, Klebsiella pneumoniaeおよびMycobacterium tuberculosisなどが検出された。市中肺炎症例の上咽頭拭い液を用いたPCRによるインフルエンザウイルスのタイピングでは、A型(H3N2)が6例、B型が1例より検出され、これらのタイプのインフルエンザウイルスが市中肺炎の初期感染として関与しているものと考えられたが、H5N1などの鳥インフルエンザウイルスは検出されなかった。

Research Products

• [Journal Article] Prevalence of Haemophilus influenzae with resistant gene isolated from young children with acute lower respiratory tract infections in Nha Trang, Vietnam. (2008)
  • Author(s): Gotoh K, Qin L, Watanabe K, Anh DD, Huong PLT, Anh NTH, Cat NDL, Ha LL, Ai LTT, Tien NM, Minh TT, Oishi K, Watanabe H.
  • Journal Title: J Infect Chemother 14 Pages: 349-353
  • Peer Reviewed
• [Journal Article] A mutational shift from domain III to II in the ribosomal entry site of hepatitis C virus with interferon-ribavirin therapy. (2008)
  • Author(s): Ogata K, Kashiwagi T, Iwahashi J, Hara K, Honda H, Ide T, Kumashiro R, Kohara M, Sata M, Watanabe H, Hamada N.
  • Journal Title: Archives of Virology 153 Pages: 1575-1579
  • Peer Reviewed
• [Journal Article] Antimicrobial effect of fluoroquinolones for the eradication of nontypeable Haemophilus influenzae isolates within biofilms. (2008)
  • Author(s): Kaji C, Watanabe K, Apicella MA, Watanabe H.
  • Journal Title: Tohoku J Exp Med 214 Pages: 121-128
  • Peer Reviewed
• [Journal Article] A nosocomial outbreak of epidemic keratoconjunctivitis accompanying environmental contamination with adenoviruses. (2008)
  • Author(s): Hamada N, Gotoh K, Hara K, Iwahashi J, Imamura Y, Nakamura S, Taguchi C, Sugita M, Yamakawa R, Etoh Y, Sera N, Ishibashi T, Chijiwa K, Watanabe H.
  • Journal Title: J Hosp Infect 68 Pages: 262-268
  • Peer Reviewed
• [Journal Article] Clinical and microbiological characteristics of community-acquired pneumonia among HIV-infected patients in northern Thailand. (2008)
  • Author(s): Watanabe H, Asoh N, Kobayashi S, Watanabe K, Oishi K, Kositsakulchai W, Sanchai T, Khantawa B, Tharavichitkul P, Sirisanthana T, Nagatake T.
  • Journal Title: J Infect Chemother 14 Pages: 105-109
  • Peer Reviewed
• [Journal Article] Drug-resistant pneumococci in children with acute lower respiratory infections in Vietnam. (2008)
  • Author(s): Watanabe K, Anh DD, Huong PLT, Nguyet NT, Anh NTH, Thi NT, Dung NT, Phong DM, Rusizoka OS, Nagatake T, Watanabe H, Oishi K.
  • Journal Title: Pediatr Int 50 Pages: 514-518
  • Peer Reviewed
• [Journal Article] Antimicrobial susceptibility and genetic characteristics of Streptococcus pneumoniae isolates indicating possible nosocomial transmission routes in a community hospital in Japan. (2007)
  • Author(s): Qin L, Masaki H, Watanabe K, Furumoto A, Watanabe H.
  • Journal Title: J Clin Microbiol 45 Pages: 3701-3706
  • Peer Reviewed
• [Journal Article] Possible prevalence and transmission of acute respiratory tract infections caused by Streptococcus pneumoniae and Haemophilus influenzae among the internally displaced persons in tsunami disaster evacuation camps of Sri Lanka. (2007)
  • Author(s): Watanabe H, Batuwanthudawe R, Thevanesam V, Kaji C, Qin L, Nishikiori N, Saito W, Saito M, Watanabe K, Oishi K, Abeysinghe N, Kunii O.
  • Journal Title: Intern Med 46 Pages: 1395-1402
  • Peer Reviewed
• [Journal Article] Increased rates of intense nasopharyngeal bacterial colonization of Vietnamese children with radiological pneumonia. (2007)
  • Author(s): Anh DD, Huong PLT, Watanabe K, Nguyet NT, Anh NTH, Thi NT, Dung NT, Phong, DM, Tanimura S, Ohkusa Y, Nagatake T, Watanabe H, Oishi K.
  • Journal Title: Tohoku J Exp Med 213 Pages: 167-172
  • Peer Reviewed
• [Journal Article] Two hydrophobic segments of the RTN1 family determine the ER localization and retention. (2007)
  • Author(s): Iwahashi J, Hamada N, Watanabe H.
  • Journal Title: Biochem Biophys Res Commun 335 Pages: 508-512
  • Peer Reviewed
• [Journal Article] Strain-specific pulmonary defense achieved after repeated airway immunizations with non-typeable Haemophilus influenzae in a mouse model. (2007)
  • Author(s): Koyama J, Ahmed K, Zhao J, Saito M Onizuka S, Oma K, Watanabe K, Watanabe H, Oishi K.
  • Journal Title: Tohoku J Exp Med 211 Pages: 63-74
  • Peer Reviewed
• [Journal Article] Antimicrobial susceptibility and genetic characteristics of Haemophilus influenzae isolated from patients with respiratory tract infections between 1987 and 2000, including β-lactamase-negative ampicillin-resistant strains. (2007)
  • Author(s): Qin L, Watanabe H, Asoh N, Watanabe K, Oishi K, Mizota T, Nagatake T.
  • Journal Title: Epidemiol Infect 135 Pages: 665-668
  • Peer Reviewed
• [Journal Article] Dynamics of dendritic cell migration and the subsequent induction of protective immunity in the lung after repeated airway challenges by nontypeable Haemophilus influenzae outer membrane protein. (2006)
  • Author(s): Kurita S, Koyama J, Onizuka S, Motomura K, Watanabe H, Watanabe K, Senba M, Apicella MA, Murphy TF, Matsushima K, Nagatake T, Oishi K.
  • Journal Title: Vaccine 24 Pages: 5896-5903
  • Peer Reviewed
• [Journal Article] Antimicrobial susceptibility and serotype distribution of Streptococcus pneumoniae isolated from patients with community-acquired pneumonia and molecular analysis of multidrug-resistant serotype 19F and 23F pneumococci in Japan. (2006)
  • Author(s): Qin L, Watanabe H, Yoshimine H, Guio H, Watanabe K, Kawakami K, Iwagaki A, Nagai H, Goto H, Kuriyama T, Fukuchi Y, Matsushima T, Kudoh S, Shimada K, Matsumoto K, Nagatake T, Mizota T, Oishi K.
  • Journal Title: Epidemiol Infect 134 Pages: 1188-1194
  • Peer Reviewed
• [Journal Article] Drug-resistant genes and serotypes of pneumococcal strains of community-acquired pneumonia among adults in Japan. (2006)
  • Author(s): Oishi K, Yoshimine H, Watanabe H, Watanabe K, Tanimura S, Kawakami K, Iwagaki A, Nagai H, Goto H, Kudoh S, Kuriyama T, Fukuchi Y, Matsushima T, Shimada S, Matsumoto K, Nagatake T.
  • Journal Title: Respirology 11 Pages: 429-436
  • Peer Reviewed
• [Journal Article] Significant reduction of nosocomial pneumonia after introduction of disinfection of upper airways using povidone-iodine in geriatric wards. (2006)
  • Author(s): Masaki H, Nagatake T, Asoh N, Yoshimine H, Watanabe K, Watanabe H, Oishi K, Rikitomi N, Matsumoto K.
  • Journal Title: Dermatology 212, suppl 1 Pages: 92-96
  • Peer Reviewed
• [Journal Article] Molecular epidemiological study of Moraxella catarrhalis isolated from nosocomial respiratory infection patients in a community hospital in Japan.
  • Author(s): Qin L, Masaki H, Gotoh K, Furumoto A, Terada M, Watanabe K, aWatanabe H.
  • Journal Title: Intern Med (in press)
  • Peer Reviewed
• [Journal Article] Nosocomial bacteremia caused by biofilm-forming Bacillus cereus and Bacillus thuringiensis.
  • Author(s): Kuroki R, Kawakami K, Qin L, Kaji C, Watanabe K, Kimura Y, Ishiguro C, Tanimura S, Tsuchiya Y, Hamaguchi I, Sakakura M, Sakabe S, Tsuji K, Inoue M, Watanabe H.
  • Journal Title: Intern Med (in press).
  • Peer Reviewed
• [Presentation] Impaired Streptococcus pneumoniae capsular polysaccharide promotes biofilm formation. (2009)
  • Author(s): Qin L, Watanabe H.
  • Organizer: US-Japan Cooperative Medical Science Program Acute Respiratory Infections Panel.
  • Place of Presentation: Chiba, Japan
  • Year and Date: 2009-01-17
• [Presentation] The immune response to human metapneumovirus in hospitalized infants. (2009)
  • Author(s): Hara K, Watanabe H.
  • Organizer: US-Japan Cooperative Medical Science Program Acute Respiratory Infections Panel.
  • Place of Presentation: Chiba, Japan
  • Year and Date: 2009-01-16
• [Presentation] Characteristics and genetic relatedness of Moraxella catarrhalis isolated from a community hospital in Japan. (2008)
  • Author(s): 秦 亮, 真崎宏則, 渡邊 浩
  • Organizer: 第78回日本感染症学会西日本地方会学術集会
  • Place of Presentation: 広島
  • Year and Date: 2008-12-05
• [Presentation] Infection control for airborne and droplet infection. (2008)
  • Author(s): Watanabe H.
  • Organizer: 4th Shanghai International Forum of Infection Control.
  • Place of Presentation: Shanghai, China
  • Year and Date: 2008-05-21
• [Presentation] Nontypable Haemophilus influenzaeが産生するバイオフィルムに対する各種抗生物質の効果に関する研究。 (2008)
  • Author(s): 後藤憲志, 渡邊 浩
  • Organizer: 第82回日本感染症学会総会
  • Place of Presentation: 松江
  • Year and Date: 2008-04-17
• [Presentation] Genetic analysis of Streptococcus pneumoniae isolates indicating possible nosocomial transmission routes in Japan. (2008)
  • Author(s): 秦 亮, 真崎宏則, 渡邊貴和雄, 古本朗嗣, 渡邊 浩
  • Organizer: 第82回日本感染症学会総会
  • Place of Presentation: 松江
  • Year and Date: 2008-04-17
• [Presentation] Analysis of the effectiveness of different classes of antibiotics for the eradication of nontypeable Haemophilus influenzae biofilms. (2008)
  • Author(s): Watanabe H, Kaji C, Watanabe K, Apicella MA.
  • Organizer: US-Japan Cooperative Medical Science Program Acute Respiratory Infections Panel.
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-02-25
• [Presentation] Clinical study of antimicrobial susceptibility of Streptococcus pneumoniae isolated from a community hospital in Japan. (2007)
  • Author(s): 秦 亮, 真崎宏則, 渡辺貴和雄, 古本朗嗣, 渡邊 浩
  • Organizer: 第55回日本化学療法学会西日本支部総会、第50回日本感染症学会中日本地方会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2007-10-31
• [Presentation] ベトナム、ナチャンにおける小児急性下気道感染症患者由来の薬剤耐性遺伝子を有するインフルエンザ菌に関する分子疫学的検討。 (2007)
  • Author(s): 後藤憲志, 渡邊 浩, 渡辺貴和雄, 大石和徳
  • Organizer: 第48回日本熱帯医学会大会
  • Place of Presentation: 大分
  • Year and Date: 2007-10-12
• [Presentation] 院内発症の菌血症症例より分離されたバイオフィルム産生Bacillus spp.に関する分子疫学的検討。 (2007)
  • Author(s): 渡邊 浩, 渡辺貴和雄, 川上健司
  • Organizer: 第55回日本化学療法学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-06-01
• [Presentation] Organisms of nosocomial infection and the prevention. (2007)
  • Author(s): Watanabe H.
  • Organizer: 3th Shanghai International Forum of Infection Control.
  • Place of Presentation: Shanghai, China
  • Year and Date: 2007-04-21
• [Presentation] Prevalence of Haemophilus influenzae with resistant gene isolated from young children with acute lower respiratory tract infections in Nha Trang, Vietnam. (2007)
  • Author(s): Watanabe H, Qin L, Goto K, Watanabe K, Anh DD, Huong PLT, Anh NTH, Cat NDL, Ha LL, Ai LTT, Tien NM, Minh TT, Oishi K.
  • Organizer: US-Japan Cooperative Medical Science Program Acute Respiratory Infections Panel.
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2007-01-22
• [Presentation] Travel associated infections-Travel clinic in Japan. (2006)
  • Author(s): Watanabe H. Symposium
  • Organizer: 10th Western Pacific Congress on Chemotherapy and Infectious Diseases
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2006-12-05
• [Book] 第5章、呼吸器疾患の治療、1. 呼吸器感染症、肺膿瘍。日本医師会雑誌第137巻・特別号(2)、生涯教育シリーズー75、呼吸器疾患診療マニュアル (2008)
  • Author(s): 秦 亮, 渡邊 浩
  • Total Pages: 197
• [Book] V. 抗菌薬投与の実際C. 抗菌薬の特徴と使い方 11. 抗ウイルス薬(HIVを除く)。感染症内科クリ二カルスタンダード (2008)
  • Author(s): 秦 亮, 渡邊 浩
  • Total Pages: 344-351
• [Book] 特集/医師として知っておきたいTravel Medicine、海外旅行と感染症ー黄熱。臨牀と研究 85 (2008)
  • Author(s): 秦 亮, 渡邊 浩
  • Total Pages: 1251-1254
  • Publisher: 臨牀と研究 85
• [Book] 院内感染で注目すべき病原体と対策ー特に手洗い、マスクの重要性についてー。臨床と研究 85 (2008)
  • Author(s): 升永憲治, 渡邊 浩, 三浦美穂
  • Total Pages: 1062-1066
• [Book] 感染症と抗菌薬の使いかたへのアプローチその1、改訂された感染症新法 と実地医家の対応。Medical Practice 25 (2008)
  • Author(s): 渡邊 浩
  • Total Pages: 744-752
• [Book] 感染症におけるリスクマネージメント、輸入感染症のリスクマネージメント。呼吸 27 (2008)
  • Author(s): 秦 亮, 渡邊 浩
  • Total Pages: 401-405
• [Book] 特集 : インフルエンザを取り巻く治療・予防の現状と課題。IV. インフルエンザの臨床像と診断。Progress in Medicine 27 (2007)
  • Author(s): 原 好勇, 渡邊 浩
  • Total Pages: 2271-2275
• [Book] 呼吸器病原菌の耐性菌激増の背景、家族内感染について。化学療法の領域 Vol. 23, No. 9 (2007)
  • Author(s): 秦 亮, 渡邊 浩
  • Total Pages: 35-40
• [Book] ヒト・メタニューモウイルスー高齢者収容施設における集団感染ー。化学療法の領域 Vol. 23, No. 8 (2007)
  • Author(s): 濱田信之, 渡邊 浩
  • Total Pages: 97-103
• [Book] ワクチンの最新事情と渡航者の接種。11. 渡航者のワクチン接種に関する情報源。日本医事新報 No. 4339 (2007)
  • Author(s): 渡邊 浩
  • Total Pages: 69-71
• [Book] 基礎・臨床の両面からみた耐性菌の現状と対策 3、ペニシリン耐性肺炎球菌。モダンメディア Vol. 53, No. 5 (2007)
  • Author(s): 渡邊 浩, 大石和徳
  • Total Pages: 122-126