2007 Fiscal Year Final Research Report Summary
The role of the corticosubthalamic pathway in dopamine-induced motor behavior
| Project/Area Number |
18500244
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Osaka University (2007)
Fukushima Medical University (2006) |
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Principal Investigator |
YASOSHIMA Yasunobu Osaka University, Behavioral Physiology, Associate Professor (00273566)
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| Project Period (FY) |
2006 – 2007
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| Keywords | dopamine / medial prefrontal cortex / subthalamic nucleus / c-fos |
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| Research Abstract |
Inhibition of the medial prefrontal cortex (mPFC) by microinfusion of GABA_A receptor agonist muscimol disrupted both hyperlocomotion and activation of c-fos gene in the subthalamic nucleus (STN) induced by dopaminergic stimulation. These behavioral and neuroanatomical reactions were mediated by dopamine D1-like and D2-like receptors in the mPFC. Many retrogradely labeled pyramidal cells in the mPFC were found following an injection of a retrograde tracer Fluoro-Gold (FG) into the STN. In contrast, anterogradely labeled fibers in the STN were seen after an intra-mPFC injection of biotinylated dextran. Subcutaneous injection of methamphetamine (METH) induced c-fos gene expression in glutamatergic, but not GABAergic, mPFC neurons. Some of c-fos-positive mPFC neurons were also labeled by FG injected into the STN, indicating that some METH-activated mPFC projection neurons monosynaptically innervate the STN. These results suggest that the mPFC projection neurons facilitate dopamine-induced hyperlocomotion via the direct excitatory input to the STN through the corticosubthalamic pathway.
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[Journal Article] Efficient gene transfer via retrograde transport in rodent and primatebrains by an HIV-1-based vector pseudotyped with rabies virus glycoprotein.2007
Author(s)
Kato, S., Inoue, K., Kobayashi, K., Yasoshima, Y., Miyachi, S., Inoue, S., Hanawa, H., Shimada, T., Takada, M., and Kobayashi, K.
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Journal Title
Human Gene Therapy 18
Pages: 1141-1151
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Efficient gene transfer via retrograde transport in rodent and primate brains by an HD/-1-based vector pseudotyped with rabies virus glycoprotein2007
Author(s)
Kato, S., Inoue, K., Kobayashi, K., Yasoshima, Y., Miyachi, S., Inoue, S., Hanawa, H., Shimada, T., Takada, M., Kobayashi, K
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Journal Title
Human Gene Therapy 18
Pages: 1141-1151
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The role of the amygdala as neural substrates in conditioned taste preference of mice2007
Author(s)
Kitazawa, M., Yoshizawa, Y, Funaki, M., Eda-Fujiwara, H., Satoh, K, Miyamoto, T., Yasoshima, Y
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Journal Title
Japanese Journal of Taste and Smell Research 14
Pages: 327-330
Description
「研究成果報告書概要(欧文)」より
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[Presentation] The role of amygdala as a neural substrate for conditioned taste preference learning in mice2007
Author(s)
Miyamoto, T., Funaki, M., Nagaki, N., Eda-Fujiwara, H., Satoh, R., Yasoshima, Y
Organizer
Neuroscience Research Supplement 1 58 : S224
Year and Date
20070000
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Differential involvements of the locus coeruleus(LC)noradrenergic(NA)system in anxiety-related behaviors and neuroendocrine stress-responses. A study using a novel method for selective ablation of the NA neurons in the LC.2007
Author(s)
Itoi, K., Suzuki, S., Otaki, I., Yasoshima, Y., and Kobayashi, K.
Organizer
Neuroscience 2007, 37th annual meeting of the Society for Neuroscience
Place of Presentation
San Diego, California
Year and Date
2007-11-06
Description
「研究成果報告書概要(和文)」より
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[Presentation] Differential involvements of the locus coeruleus(LC) noradrenergic(NA) system in anxiety-related behaviors and neuroendocrine stress-responses. A study using a novel method for selective ablation of the NA neurons in the LC2007
Author(s)
Itoi, K., Suzuki, S., Otaki, I., Yasoshima, Y., and Kobayashi, K
Organizer
Neuroscience 2007, 37th Annual Meeting of the Society for Neuroscience
Place of Presentation
San Diego, California
Year and Date
2007-11-06
Description
「研究成果報告書概要(欧文)」より
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