2007 Fiscal Year Final Research Report Summary
Functional analysis of dystrophin isoforms using DMD-null mice
| Project/Area Number |
18500320
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Kitasato University |
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Principal Investigator |
HANAOKA Kazunori Kitasato University, School of Sci., Prof (40189577)
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| Co-Investigator(Kenkyū-buntansha) |
UCHIYAMA Koji Kitasato Univ., Schad of Sci., Res. Assis (20276174)
WATANABE Daisuke Kitasato Univ., Schod of Sci., Res. Assis (00260175)
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| Project Period (FY) |
2006 – 2007
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| Keywords | DMD / muscular dystrophy / dystrophin isoforms / muscle / mdx / spermiogenesis / olfactory sensory neuron / vomeronasal nerve |
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| Research Abstract |
The Duchenne muscular dystrophy (DMD) gene encodes dystrophin, which is a protein defective in DMD patients, as well as a number of shorter isoforms, which have been shown to be expressed in various non-muscle tissues. As of yet, the physiological function of the various dystrophin isoforms is not fully understood. In the present study, we investigated phenotypic alterations appeared in the DMD-null mice, where expression of all dystrophin isoforms had been totally disrupted. The MID -null mice were viable but displayed severe muscular hypertrophy and dystrophy, and also male sterility. In addition, we found that vomeronasal axons in the DMD-null mice are defasciculated, and some of the defasciculated vomeronasal axons aberrantly entered into the main olfactory bulb. These results suggest that the dystrophin isoforms play various important roles in a variety of tissues in the mouse.
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Research Products
(19 results)
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[Journal Article] Epimorphin acts extracellularly to promote cell sorting and aggregation during the condensation of vertebral cartilage2006
Author(s)
Yumiko, Oka, Yuki, Sato, Hokari, Tsuda, Kazunori, Hanaoka, Yohei, Hirai, Yoshiko, Takahashi
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Journal Title
Develop. Biol 291
Pages: 25-37
Description
「研究成果報告書概要(欧文)」より
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