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2007 Fiscal Year Final Research Report Summary

Functional analysis of dystrophin isoforms using DMD-null mice

Research Project

Project/Area Number 18500320
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionKitasato University

Principal Investigator

HANAOKA Kazunori  Kitasato University, School of Sci., Prof (40189577)

Co-Investigator(Kenkyū-buntansha) UCHIYAMA Koji  Kitasato Univ., Schad of Sci., Res. Assis (20276174)
WATANABE Daisuke  Kitasato Univ., Schod of Sci., Res. Assis (00260175)
Project Period (FY) 2006 – 2007
KeywordsDMD / muscular dystrophy / dystrophin isoforms / muscle / mdx / spermiogenesis / olfactory sensory neuron / vomeronasal nerve
Research Abstract

The Duchenne muscular dystrophy (DMD) gene encodes dystrophin, which is a protein defective in DMD patients, as well as a number of shorter isoforms, which have been shown to be expressed in various non-muscle tissues. As of yet, the physiological function of the various dystrophin isoforms is not fully understood. In the present study, we investigated phenotypic alterations appeared in the DMD-null mice, where expression of all dystrophin isoforms had been totally disrupted. The MID -null mice were viable but displayed severe muscular hypertrophy and dystrophy, and also male sterility. In addition, we found that vomeronasal axons in the DMD-null mice are defasciculated, and some of the defasciculated vomeronasal axons aberrantly entered into the main olfactory bulb. These results suggest that the dystrophin isoforms play various important roles in a variety of tissues in the mouse.

  • Research Products

    (19 results)

All 2008 2007 2006 Other

All Journal Article (11 results) (of which Peer Reviewed: 5 results) Presentation (8 results)

  • [Journal Article] Skeletogenesis in Xenopus tropicalis: Characteristic bone development inan anuran amphibian2008

    • Author(s)
      S.Miura, K. Hanaoka, S.Togashi
    • Journal Title

      Bone (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Involvement of Short Dystrophin Isoform Dp71 in Organization of Mouse Vomeronasal Nerve2008

    • Author(s)
      Takatoh J, Kudo H, Kondo S, Hanaoka K.
    • Journal Title

      Exp.Neurol (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Heparan sulfate regulates self-renewal and pluripotency of embryonic stem cells2008

    • Author(s)
      Sasaki N, Okishio K, Kumiko Ui-Tei, et. al.
    • Journal Title

      J.Biol.Chem 283

      Pages: 3594-3606

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Heparan sulfate regulates self-renewal and pluripotency of embryonic stem cells2008

    • Author(s)
      Sasaki, N, Okishio, K, Kumiko, Ui-Tei, et. al.
    • Journal Title

      J. Biol. Chem 283(6)

      Pages: 3594-3606

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Functional analysis of homeodomain- containing transcription factor,Lbxl,in satellite cells of mouse skeletal muscles2007

    • Author(s)
      Watanabe S, Kondo S and Hanaoka K
    • Journal Title

      J.Cell Sci 33

      Pages: 4178-4187

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Functional analysis of homeodomain- containing transcription factor, Lbx1, in satellite cells of mouse skeletal muscles.2007

    • Author(s)
      Watanabe, S, Kondo, S, Hanaoka, K
    • Journal Title

      J. Cell Sci 120(23)

      Pages: 4178-4187

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Transition of mouse de novo methytransferases expression from Dnmt3b to Dmnt3a during neural progenitor cell development2006

    • Author(s)
      Watanabe D, Uchiyama K and HanaokaK.
    • Journal Title

      Dev.Biol 291

      Pages: 25-37

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Transition of mouse de novo methytransferases expression from Dnmt3b to Dmnt3a during neural progenitor cell development2006

    • Author(s)
      D, Watanabe, K, Uchiyama, K, Hanaoka
    • Journal Title

      Neuroscience 142

      Pages: 727-737

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Epimorphin acts extracellularly to promote cell sorting and aggregation during the condensation of vertebral cartilage2006

    • Author(s)
      Yumiko, Oka, Yuki, Sato, Hokari, Tsuda, Kazunori, Hanaoka, Yohei, Hirai, Yoshiko, Takahashi
    • Journal Title

      Develop. Biol 291

      Pages: 25-37

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Skeletogenesis in Xenopus tropicalis : Characteristic bone development in an anuran amphibian

    • Author(s)
      S., Miura, K., Hanaoka, S., Togashi
    • Journal Title

      Bone (In press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Involvement of Sho Dystrophin Isoform Dp71 in Organization of Mouse Vomeronasal Nerve

    • Author(s)
      Takatoh, J, Kudo, H, Kondo, S, Hanaoka, K
    • Journal Title

      Exp. Neurol (In press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Loss of short dystrophin isoform Dp71 in olfactory ensheathing cells causes vomeronasal nerve defasciculation in and mouse olfactory system2006

    • Author(s)
      Jun, Takatoh, Hiroe, Kudoh, Shunzo, Kondoh, Kazunori, Hanaoka
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      20060000
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Coordinated expression of mouse de novo methyltransferases from Dnmt3b to Dnmt3a, during ES cell differentiation and olfactory neurogenesis2006

    • Author(s)
      Watanabe, D, Uchiyama, K, Hanaoka, K
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      20060000
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] サテライト細胞におけるLbx1遺伝子の機能解析2006

    • Author(s)
      渡部 秀一、近藤 俊三、早坂 美智子、花岡 和則
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋
    • Year and Date
      2006-12-08
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Coordinated expression of mouse de novo methyltransferases from Dnmt3b to Dnmt3a, during ES cell differentiation and olfactory neumgenesis2006

    • Author(s)
      Watanabe D, Uchiyama K and Hanaoka K
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-23
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Loss of short dystrophin isoform Dp71 in olfactory ensheathing cells causes vome ronasal nerve defasciculation in mouse olfactory system2006

    • Author(s)
      Jun Takatoh, Hiroe Kudoh, Shunzo Kondoh and Kazunori Hanaoka
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] A novel transgenic mouse line with the imprinted transgenes2006

    • Author(s)
      内山 孝司, 渡辺 大介, 早坂 美智子, 花岡 和則
    • Organizer
      日本発生生物学会第39回大会
    • Place of Presentation
      京都
    • Year and Date
      2006-06-02
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 恒常的にsiRNAを発現するトランスジェニックマウスの作成及びその解析2006

    • Author(s)
      上條 裕貴, 渡辺 大介, 花岡 和則
    • Organizer
      日本発生生物学会第39回大会
    • Place of Presentation
      京都
    • Year and Date
      2006-06-01
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] IIb型ナトリウム依存性リン共輸送体はマウス初期発生に必須である2006

    • Author(s)
      柴崎 友里, 江藤 伸晃, 早坂 美智子, 高橋 基夫, 柿谷 誠, 山下 武美, 富塚 一磨, 花岡 和則
    • Organizer
      日本発生生物学会第39回大会
    • Place of Presentation
      京都
    • Year and Date
      2006-06-01
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-02-04  

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