2007 Fiscal Year Final Research Report Summary
Fundamental Study on Molecular Imaging by Fluorescent X-Ray CT
Project/Area Number |
18500341
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biomedical engineering/Biological material science
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Research Institution | Yamagata University |
Principal Investigator |
YUASA Tetsuya Yamagata University, Graduate School of Science and Engineering, 教授 (30240146)
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Co-Investigator(Kenkyū-buntansha) |
TAKEDA Tohoru University of Tsukuba, Graduate School of Comprehensive Human Sciences, 講師 (10197311)
WU Jin University of Tsukuba, Graduate School of Comprehensive Human Sciences, 講師 (20375512)
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Project Period (FY) |
2006 – 2007
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Keywords | Synchrotron X-Ray / Fluorescent X-Ray / Computed Tomography / Tomoeranhic Imaging / Molecular Imaging |
Research Abstract |
Fluorescent x-ray computed tomography (FXCT) that can detect and image a trace of non-radioactive imaging agent, e. g., iodine, in a biomedical subject at a high spatial resolution can be a novel molecular imaging modality. Presently, we are developing an FXCT system using synchrotron radiation as an x-ray source for in-vivo imaging brains of small animals such as mouse, rat, and so on. For the purpose, we must overcome the following two difficulties damaging an image-quality: One difficulty is that the number of projections is remarkably restricted due to the long data-acquisition time. In order to reduce the measurement time, we propose to eliminate unnecessary beam scans by adaptively and efficiently controlling the scanning according to the subject size. The other difficulty is that the measured data are contaminated by inevitable physical factors. Here, we propose data-processing methods to estimate reliable projections from raw data. The efficacies of the proposed methods are demonstrated using physical-phantom images and an in-vivo image of mouse brain, which were reconstructed from experimental data acquired in KEK, Japan.
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[Journal Article] 3-D Reconstruction of High-Guctal Carcinoma In Situ of the Breast with Casting Type Calcifications using Refraction-based X-Ray CT2008
Author(s)
S., Ichihara・M., Ando・E., Hashimoto・A., Maksimenko・H., Sugiyama・C., Ohbayashi・T., Yuasa・K., Yamasaki・Y., Arai・K., Mori・T., Endo
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Journal Title
Virchows Archiv 452
Pages: 41-47
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] 3-D Reconstruction of High-Grade Ductal Carcinoma In Situ of the Breast with Casting Type Calcifications using Refraction-based X-Ray CT2008
Author(s)
S. Ichihara, M. Ando, E. Hashimoto, A. Maksimenko, H. Sugiyama, C. Ohbayashi, T. Yuasa, K. Yamasaki, Y. Arai, K. Mori, and T. Endo
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Journal Title
Virchows Archiv Vol.452, No.1
Pages: 41-47
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Whole-atom Compton scattering cross-sections and individual shell cross-sections for the biological elements in the energy region from 1 to 4 keV2007
Author(s)
D., V., Rao・T., Yuasa・T., Akasuka・G., Tromba・T., Takeda・R., Cesareo・A., Brunetti・G., E., Gigigante
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Journal Title
Nuclear Instruments and Methods in Physics Research B 261
Pages: 193-196
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Quantitative evaluation of myocardial function by a volume-normalized map generated from relative blood flow2007
Author(s)
T., Fukami・H., Sato・J., wu・Thet-Thet-Lwin・T., Yuasa・S., Kawano・K., Iida・T., Akatsuka・H., Hontani・T., Takeda・M., tamura・H., Yokota
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Journal Title
Physics in Medicine and Biology 52
Pages: 4311-4330
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Myocardinal Fatty Acid Metabolic Imaging by Fluorescent X-Ray Computed Tomography Imaging2007
Author(s)
Thet-Thet-Lwin・T., Takeda・J., Wu・N., Sunaguchi・T., Murakami・S., Mouri・S., Nasukawa・Q., Huo・T., Yuasa・K., Hyodo・T., Akatsuka
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Journal Title
Journal of Synchrotron Radiation 14/1
Pages: 158-162
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Quantitative evaluation of myocardial function by a volume-normalized map generated from relative blood flow2007
Author(s)
T. Fukami, H. Sato, J. Wu, Thet-Thet-Lwin, T. Yuasa, S. Kawano, K. lida, T. Akatsuka, H. Hontani, T. Takeda, M. Tamura, and H. Yokota
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Journal Title
Physics in Medicine and Biology Vol.52, No.14
Pages: 4311-4330
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Myocardinal Fatty Acid Metabolic Imaging by Fluorescent X-Ray Computed Tomography Imaging2007
Author(s)
Thet-Thet-Lwin, T. Takeda, J. Wu, N. Sunaguchi, T. Murakami, S. Mouri, S. Nasukawa, Q. Huo, T. Yuasa, K. Hyodo, T. Akatsuka
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Journal Title
Journal of Synchrotron Radiation Vol.14, No.1
Pages: 158-162
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] 2D and 3D Visualization of Ductal Carcinoma in situ (DCIS) using X-Ray Refraction Contrast2006
Author(s)
M., Ando・A., Maksimenko・T., Yuasa・E., Hashimoto・K., Yamasaki・C., ohbayashi・H., Sugiyama・K., Hyodo・T., Kimura・H., Esumi・T., Akatsuka・G., Li・D., Xian・E., Ueno・H., Bando・S., Ichihar
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Journal Title
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] First attempt at 3D X-ray visualization of DCIS (ductal carcinoma in situ) due to refiraction contrast - In good relation to pathological view2006
Author(s)
M., Ando・T., Akatsuka・H., Bando・Y., Chikaura・T., Endo・E., Hashimoto・K., Hirano・K., Hyodo・S., Ichihara・A., Maksimenko・C., Ohbayashi・H., Sugiyama・E., Ueno・K., Yamasaki・T., Yuasa
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Journal Title
Digital Mammography, proceedings Lecture Notes in Computer Science 4046
Pages: 525-532
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Interlaced X-ray Microplanar Arrays: A Novel Radiosurgery Approach with Clinical Potential2006
Author(s)
A., Dilmanian・Z., Zhong・T., Bacarian・H., Benveniste・P., romanelli・R., Wang・J., Welwart・T., Yuasa・E., M., Rosen・D., J., Anschel
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Journal Title
Proc. Natl. Acad. Sci. USA 103/25
Pages: 9709-9714
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Tomographic images of few soft materials and embedded biological soft tissue using tube source of X-rays at optimum energy2006
Author(s)
D., V., Rao・T., Yuasa・T., Akatsuka・R., Cesareo・G., E., Gigante・M., Z., Hasan・T., Takeda
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Journal Title
NDT & E international 39/1
Pages: 34-38
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Tomographic images of few soft materials and embedded biological soft tissue using tube source of X-rays at optimum energy2006
Author(s)
D., V., Rao・<T., Yuasa>・T., Akatsuka・R., Cesareo・G., E., Gigante・M., Z., Hasan・T., Takeda
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Journal Title
NDT & E international 39/1
Pages: 34-38
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Progress in biomedical application of phase-contrast x-ray imaging and fluorescent x-ray CT2006
Author(s)
T., Takeda・J., Wu・T., T., Lwin・A., Yoneyama・Y., Hirai・K., Hyodo・N., Sunaguchi・T., Yuasa・M., Minami・K., Kose・T., Akatsuka:
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Journal Title
Proc. SPIE 6318/38
Pages: 63180W
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Application of x-ray computed tomography based on the refraction contrast to biomedicine2006
Author(s)
E., Hashimoto・A., Maksimenko・H., Sugiyama・K., Hyodo・D., Shimao・T., Yuasa・Y., Nishino・T., Ishikawa・K., Mori・Y., Arai・K., Hirano・M., Ando
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Journal Title
Proc. SPIE 6142
Pages: 614213
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] 2D and 3D Visualization of Ductal Carcinoma in situ(DCIS) using X-Ray Refraction Contrast2006
Author(s)
M. Ando, A. Maksimenko, T. Yuasa, E. Hashimoto, K. Yamasaki, C. Ohbayashi, H. Sugiyama, K. Hyodo, T. Kimura, H. Esumi, T. Akatsuka, G. Li, D. Xian, E. Ueno, H. Bando, S. Ichihara, T. Endo, N. M. and H. Nishio
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Journal Title
Bioimages Vol.14
Pages: 1-8
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] First attempt at 3D X-ray visualization of DCIS(ductal carcinoma in situ) due to refraction contrast-In good relation to pathological view, Digital Mammography2006
Author(s)
M. Ando, T. Akatsuka, H. Bando, Y. Chikaura, T. Endo, E. Hashimoto, K. Hirano, K. Hyodo, S. Ichihara, A. Maksimenko, C. Ohbayashi, H. Sugiyama, E. Ueno, K. Yamasaki, T. Yuasa
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Journal Title
Proceedings Lecture Notes in Computer Science 4046
Pages: 525-532
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Synchrotron Radiation Used Fluorescent X-Ray Computed Tomography as a Nove1 Molecular Imaging2007
Author(s)
N., Sunaguchi・Q.K., Huo・S., Nasukawa・N., Maikusa・T., Fukami・T., Yuasa, ・T., Takeda・J., Wu・Thet-Thet-Lwin・K., Hyodo・F.A., Dilmanian・T., Akastsuka
Organizer
IASTED Visualization, Imaging and Image Processing
Place of Presentation
Spain
Year and Date
20070800
Description
「研究成果報告書概要(和文)」より
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[Presentation] In-vivo Fluorescent X-ray CT Imaging of Mouse Brain2007
Author(s)
T., Takeda・J., Wu・Thet-Thet-Lwin・Q., Huo・N., Sunaguchi・T., Murakami・S., Mouri・S., Nasukawa・T. Yuasa, ・K., Hyodo・F.A., Dilmanian・M., Minami・T., Akatsuka
Organizer
AIP Synchrotron Radiation Instrumentation: 9th International Conference
Place of Presentation
Korea
Year and Date
20070700
Description
「研究成果報告書概要(和文)」より
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[Presentation] Synchrotron Radiation Used Fluorescent X-Ray Computed Tomography as a Novel Molecular Imaging2007
Author(s)
N. Sunaguchi, Q.-K. Huo, S. Nasukawa, N. Maikusa, T. Fukami, T. Yuasa, T. Takeda, J. Wu, Thet-Thet-Lwin, K. Hyodo, F. A. Dilmanian, and T. Akatsuka
Organizer
Proc IASTED, Visualization, Imaging and Image Processing
Year and Date
20070000
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 2D and 3D Refraction Based X-ray Imaging Suitable for Clinical and Pathological Diagnosis2007
Author(s)
M. Ando, H. Bando, Z. Chen, Y. Chikaura, C.-H. Choi, T. Endo, H. Esumi, L. Gang, E. Hashimoto, K. Hyodo, S. Ichiura, S.-H. Jheon, H.-T. Kim, J.-K. Kim, T. Kimura, C.-H. Lee, A. Maksimenko, C. Ohbayashi, S.-H. Park, D. Shimao, H. Sugiyama, J. Tang, E. Ueno, K. Yamasaki, and T. Yuasa
Organizer
AIP Conference Proceedings CP705, Synchrotron Radiation Instrumentation : 9th International Conference CP879
Year and Date
20070000
Description
「研究成果報告書概要(欧文)」より
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[Presentation] In-vivo Fluorescent X-ray CT Imaging of Mouse Brain2007
Author(s)
T. Takeda, J. Wu, Thet-Thet-Lwin, Q. Huo, N. Sunaguchi, T. Murakami, S. Mouri, S. Nasukawa, T. Yuasa. K. Hyodo, F.A. Dilmanian, M. Minami, and T. Akatsuka
Organizer
AIP Conference Proceedings CP879, Synchrotron Radiation Instrumentation : 9th International Conference CP879
Year and Date
20070000
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Validity of Fusion Imaging of Hamster Heart Obtained by Fluorescent and Phase-Contrast X-Ray CT with Synchrotron Radiation2007
Author(s)
J. Wu, T. Takeda, Thet-Thet-Lwin, Q. Huo, N. Sunaguchi, T. Murakami, S. Mouri, S. Nasukawa, T. Fukami, T. Yuasa, K. Hyodo, H. Hontani, M. Minami, and T. Akatsuka
Organizer
AIP Conference Proceedings CP879, Synchrotron Radiation Instrumentation : 9th International Conference, CP879
Year and Date
20070000
Description
「研究成果報告書概要(欧文)」より
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[Presentation] High Quality Image of Biomedical Object by X-ray Refraction Based Contrast Computed Tomography2007
Author(s)
E. Hashimoto, A. Maksimenko, H. Sugiyama, K. Hirano, K. Hyodo, D. Shimao, Y. Nishino, T. Ishikawa, T. Yuasa, S. Ichihara, Y. Arai and M. Ando
Organizer
AIP Conference Proceedings CP705, Synchrotron Radiation Instrumentation : 9th International Conference CP879
Year and Date
20070000
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 3D Visualization of DCIS by high resolution synchrotron CT2006
Author(s)
S. Ichihara, M. Ando, A. Maksimenko, H. Sugiyama, E. Hashimoto, T. Yuasa, H. Bando, E. Ueno, K. Yamazaki, C. Ohbayashi, and K. Hanioka
Organizer
Modern Pathology 19
Year and Date
20060000
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Progress in biomedical application of phase-contrast x-ray imaging and fluorescent x-ray CT2006
Author(s)
T. Takeda, J. Wu, T. T. Lwin, A. Yoneyama, Y. Hirai, K. Hyodo, N. Sunaguchi, T. Yuasa, M. Minami, K. Kose, T. Akatsuka
Organizer
Proc. SPIE
Year and Date
20060000
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Application of x-ray computed tomography based on the refraction contrast to biomedicine2006
Author(s)
E. Hashimoto, A. Maksimenko, H. Sugiyama, K. Hyodo, D. Shimao, T. Yuasa, Y. Nishino, T. Ishikawa, K. Mori, Y. Arai, K. Hirano, and M. Ando
Organizer
Proc. SPIE
Year and Date
20060000
Description
「研究成果報告書概要(欧文)」より