Hyperthermic treatment for early stage of rheumatoid arthritis

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 18500417
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: KOKURA Satoshi Kyoto Prefectural University of Medicine, Department of Biomedical Safety Science, Assistant Professor (80347442)
• Co-Investigator(Kenkyū-buntansha): YOSHIKWA Toshikazu Kyoto Prefectural University of Medicine, Department of Inflammation and Immunology, Professor (90158410) ; YOSHIDA Norimasa Kyoto Prefectural University of Medicine, Department of Molecular Gastroenterology and Hepatology, Assistant Professor (30166962) ; NAITO Yuji Kyoto Prefectural University of Medicine, Department of Medical Proteomics, Associate Professor (00305575) ; HANDA Osamu Kyoto Prefectural University of Medicine, Department of Biomedical Safety Science, Associate Professor (90381970) ; TAKAGI Tomohisa Kyoto Prefectural University of Medicine, Departmerrt of Biomedical Safety Science, Associate Professor (70405257)
• Project Period (FY): 2006 – 2007
• Keywords: Rheumatoid arthritis / hyperthermia / anti-inflammatory action / 炎症性サイトカイン / IL-8 / 血管内皮細胞 / 細胞接着分子 / コラーゲン惹起免疫関節炎

Research Abstract

A main pathological change of the Rheumatoid arthritis is articular destruction.
The etiology is not yet clear, but, by some kind of mechanisms, inflammation begins mainly on a synovium.
Various cytokine and reactive oxygen species are produced by the interaction such as T- lymphocytes, B- lymphocytes, a macrophage, a neutrophil, vascular endothelial cells, and cytokine and active oxygen cause the growth of synovial cells, and these stimulate osteoclasts at the same time and cause osteoclasia, and, as a result, articular transformation occurs. Therefore, when we treat the patients with RA, it is important to control the inflammation due to cytokine and reactive oxygen species, in terms of a prognosis of patients. One of the representative physiotherapy provided for RA has hyperthermia therapy now. This hyperthermia therapy is aimed for palliation of the articular pain and stiffness. On the other hand, we clarified that hyperthermia therapy had anti-inflammatory action recently.
In this study, we planned a study for the purpose of the development of the hyperthermia therapy as the strong therapy for the onset early stage for RA. By this study, it was successful for the manufacture of the trial manufacture container of the whole-body hyperthermia using near-infrared light to enable human clinical application as well as fundamental researches using a RA model mouse. We want you to expect future development.

Research Products

• [Journal Article] Whole body hyperthermia improves obesity-induced insulin resistance in diabetic mice (2007)
  • Author(s): Satoshi Kokura
  • Journal Title: Int J Hyperthermia 23 Pages: 259-265
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Hyperthermia attenuates TNF-alpha-induced up regulation of endothelial cell adhesion molecules in human arterial endothelial cells (2007)
  • Author(s): Nami Makabe
  • Journal Title: Int J Hyperthermia 23 Pages: 217-224
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Hyperthermia ameliorates2,4,6-Trinitrobenzene Sulphonic Acid-induced colitis in rats:the role of heat shock proteins (2007)
  • Author(s): Satoshi Kokura
  • Journal Title: Int J Hyperthermia 23 Pages: 17-28
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Whole body hyperthermia improves obesity-induced insulin resistance in diabetic mice (2007)
  • Author(s): Kokura, S., Adachi, S., Manabe, E., Mizushima, K., Hattori, T., Okuda, T., Nakabe, N., Handa, O., Takagi, T., Naito, Y., Yoshida, N., Yoshikawa, T
  • Journal Title: Int J Hyperthermia 23 Pages: 259-265
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hyperthermia attenuates TNF-alpha-induced up regulation of endothelial cell adhesion molecules in human arterial endothelial cells (2007)
  • Author(s): Nakabe, N., Kokura, S., Shimozawa, M., Katada, K., Sakamoto, N., Ishikawa, T., Handa, O., Takagi, T., Naito, Y., Yoshida, N., Yoshikawa, T
  • Journal Title: Int J Hyperthermia 23 Pages: 217-224
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hyperthermia ameliorates 2, 4, 6- Trinitrobenzene Sulphonic Acid-induced colitis in rats: the role of heat shock proteins (2007)
  • Author(s): Kokura, S., Yoshida, N., Okuda, T., Nakabe, N., Sakamoto, N., Isozaki, Y., Hattori, T., Handa, O., Takagi, T., Naito, Y., Yoshikawa, T
  • Journal Title: Int J Hyperthermia 23 Pages: 17-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Effect of whole body hyperthermia for the early stage of rheumatoid arthritis- (2006)
  • Author(s): Inoue, M., Kokura, S., Nakabe, N., Takagi, T., Mizushima, K., Adachi, S., Handa, O., Manabe, E., Naito, Y., Yoshida, N., Yoshikawa, T
  • Organizer: The 4th Asian Congress of Hyperthermic Oncology &The 23rd Japanese Congress of Hyperthermic Oncology
  • Place of Presentation: Nara
  • Year and Date: 20060922-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Effect of Whole body hyperthermia for the early stage of rheumatoid arthritis in animal model (2006)
  • Author(s): Inoue, M., Kokura, S., Nakabe, N., Takagi, T., Mizushima, K., Adachi, S., Handa O., Manabe, E., Naito, Y., Yoshikawa, T
  • Organizer: 12th Congress of the Asia Pacific league of associations for rheumatology
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 20060803-04
  • Description: 「研究成果報告書概要(欧文)」より