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2007 Fiscal Year Final Research Report Summary

Nerve protective action by kynurenic acid treatment in a rat model of photochemically induced thrombosis causing focal cerebral ischemia

Research Project

Project/Area Number 18500424
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionJikei University School of Medicine

Principal Investigator

ABO Masahiro  Jikei University School of Medicine, School of Medicine, Professor (00266587)

Co-Investigator(Kenkyū-buntansha) YAMAUCHI Hideki  The Jikei University, School of Medicine, Assistant P (60220224)
Project Period (FY) 2006 – 2007
KeywordsRehabilitation / Kynurenic arid / Rose Bengal / GFAP / Stathmin / Laminin / Ischemia / motor recovery
Research Abstract

We demonstrated previously the presence of activated areas in the ipsilateral sensorimotor cortex surrounding areas of cerebral infarction, using a rat model of focal photochemically-induced thrombosis (PIT). Using this model, we next used the images of two-dimensional poly-acrylamide gel electrophoresis (2D-PAGE) and peptide mass fingerprinting (PMF) analysis to screen key proteins upregulated in the activated area. 2D-PAGE and PMF identified Laminin receptor 1, Apolipoprotein-E, Enolase 2, Stathmin 1 and Glial fibrillary acidic protein delta (GFAP) as the main proteins. GFAP expression in the cortical area surrounding the lesion increased from 48 to 96 h after PTI as confirmed by immunodetection.
In conclusion, we showed that Laminin, Apo-E, Enolase, Stathmin and GFAP are important proteins for recovery from hemiplegia in the rat thrombosis model. In particular, the results showed that astrocytes, which are related to these proteins, play an important role in behavioral recovery in the PIT model.

  • Research Products

    (5 results)

All 2007 2006

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Urashima M. Facilitated beam-walking recovery during acute phase by kynurenic acid treatment in a rat model of photochemically induced thrombosis causing focal cerebral ischemia2007

    • Author(s)
      Abo, M., Yamauchi, H., Suzuki, M., Sakuma, M
    • Journal Title

      Neurosignals 15(2)

      Pages: 102-10

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Facilitated Beam-Walking Recovery during Acute Phase by Kynurenic Acid Treatment in a Rat Model of Photochemically Induced Thrombosis Causing Focal Cerebral Ischemia2006

    • Author(s)
      Abo M, Yamauchi H, Suzuki M, Sakuma M, Urashima M
    • Journal Title

      NeuroSignals 15

      Pages: 102-110

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Is the ipsilateral cortex surrounding the lesion or the non-injured contralateral cortex important for motor recovery in rats with photochemically induced cortica! lesions2006

    • Author(s)
      Takata K, Yamauchi H, Tatsuno H, Hashimoto K, Abo M
    • Journal Title

      Eur Neurol 56

      Pages: 106-112

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Is the ipsilateral cortex surrounding the lesion or the non-injured contralateral cortex important for motor recovery in rats with photochemically induced cortical lesions?2006

    • Author(s)
      Takata, K., Yamauchi, H., Tatsuno, H., Hashimoto, K., Abo, M
    • Journal Title

      Eur Neurol 56(2)

      Pages: 106-12

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Beam-walking recovery by Kynurenic acid treatment in PIT models2007

    • Author(s)
      Abo, M., et. al.
    • Organizer
      4th World Congress of the ISPRM
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      20070600
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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