2007 Fiscal Year Final Research Report Summary
Capillary activation in general organs by physical training in special reference to bone-marrow-derived cells
| Project/Area Number |
18500506
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Akita University |
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Principal Investigator |
NANJO Hiroshi Akita University, School of medicine, Lecturer (70250892)
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| Co-Investigator(Kenkyū-buntansha) |
MASUDA Hirotake Akita University, School of medicine, professor (60103462)
KAWAMURA Koichi Akita University, School of medicine, associate professor (00091801)
TAKAHASHI Masato Akita University, School of medicine, associate professor (10315806)
KOBAYASHI Mikio Akita University, School of medicine, technician (20375306)
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| Project Period (FY) |
2006 – 2007
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| Keywords | endothelial cell / bone marrow origin / capillary / heart / vascular remodeling / aorta / striated muscle / training |
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| Research Abstract |
In vivo localization and distribution of endothelial cells of bone marrow origin has not well known in systemic organs. So we investigated their localization and distribution in special reference to physical training using bone marrow transplantation (BMT) chimeric mice using male C57BL/6J mice as recipients and male GFP mice (C57BL/6J-Tg: CAG-EGFP transgenic mouse) as donors. The results were as follows. A lot of GFP-positive CD34-positive, MIB-5 positive, and Brdu-positive endothelial cells of donor bone marrow origin were present at the cardiac capillaries, cardiac valves, ascending aorta orifice, renal capillaries in the BMT chimeric recipient mice. Endothelial cells of bone marrow origin were present at the blood-brain barrier, hepatic and splenic sinusoids, and any other general organs. Endothelial cells of bone marrow origin were few at the striated muscle capillaries. But, by physical training of two to four months periods, GFP-positive endothelial cells of bone marrow origin could be more mobilized at the lower limb striated muscle capillaries than control.
Endothelial progenitor cell localization and differentiation may be closely associated with vascular remodeling and hemodynamic conditions. Furthermore, pericytic and dendritic cells of bone marrow origin were present at the cardiac capillaries and aorta. Modulating distribution of endothelial progenitor cells may represent a novel therapeutic strategy in vascular remodeling and cardiovascular disease.
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[Presentation] 3-day high-flow loaded rabbit carotid artery remodels automatically ex vivo.2007
Author(s)
Komatsu, M., Takahashi, M., Kobayashi, M., Kawamura, K., Nanjo, H., Masuda, H.
Organizer
Arteriosclerlosis, Thrombosis, and Vascular Biology, Annual Conference
Place of Presentation
Illinois, USA
Year and Date
20070400
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Intercalated discs create and dispose sarcomeres-An observation of volume overloaded and/ or overload-removed rabbit hearts.2006
Author(s)
Masuda, H., Yoshida M., Kawamura, K., Kobayashi, M., Takahashi, M., Nanjo, H., Sho, E., Komatsu M., Honma, M.
Organizer
5th World Congress of Biomechanics
Place of Presentation
Munich, Germany
Year and Date
20060700
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Endothelial cell proliferation after transitory and short time high-flow loading.2006
Author(s)
Takahashi, M., Yoshida M., Kobayashi, M., Komatsu M., Nanjo, H., Kawamura, K., Masuda, H.
Organizer
14th International Vascular Biology Meeting
Place of Presentation
Noordwijkerhout, The Netherlands
Year and Date
20060600
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Special cells are participating in high-flow induced endothelial cell proliferation.2006
Author(s)
Kobayashi, M., Takahashi, M., Komatsu M., Yoshinari Y., Nanjo, H., Kawamura, K., Masuda, H.
Organizer
14th International Vascular Biology Meeting
Place of Presentation
Noordwijkerhout, The Netherlands
Year and Date
20060600
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 1. 5-day transient high blood flow tears internal elastic lamina after 7-day.2006
Author(s)
Komatsu M., Kobayashi, M., Takahashi, M., Nanjo, H., Kawamura, K., Masuda, H.
Organizer
14th International Vascular Biology Meeting
Place of Presentation
Noordwijkerhout, The Netherlands
Year and Date
20060600
Description
「研究成果報告書概要(欧文)」より
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