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2007 Fiscal Year Final Research Report Summary

Effects of Lifestyle Factors on Clinical Outcomes of Prevention and Care of Diabetes

Research Project

Project/Area Number 18500534
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionOchanomizu University

Principal Investigator

SONE Hirohito  Ochanomizu University, Graduate School of Humanities and Sciences, Associate Professor (30312846)

Project Period (FY) 2006 – 2007
Keywordsdiabetes mellitus / diabetic complications / cohort study / nephropathy / risk factor / lifestyle / smoking / exercise
Research Abstract

Diabetes mellitus and other lifestyle-related diseases are one of main health issues in most industrialized countries including Japan. Necessity and importance of their clinical evidences, which is useful in establishing strategies and for their prevention and care, are more and more increasing in these days. In this project, we evaluated effects of lifestyle factors such as diet, exercise, smoking, alcohol intake, etc. on various clinical parameters related to prevention and care of diabetes and other lifestyle-related diseases. By utilizing historical cohort design, meta-analysis and other methods, we could establish many important clinical evidences that could be applied in clinical settings. For example, we could find that smoking is a very important and dose-dependent risk factor for Japanese patients with diabetes to develop diabetic nephropathy. We could also clarify appropriate and suitable way of exercise for efficiently increasing HDL-cholesterol. Such results were reported in many international journals like Diabetes Care, Annals of Internal Medicine, and so on.

  • Research Products

    (39 results)

All 2008 2007 2006

All Journal Article (22 results) (of which Peer Reviewed: 11 results) Presentation (13 results) Book (4 results)

  • [Journal Article] Importance of Lipid Levels in Elderly Diabetic Individuals.2008

    • Author(s)
      Hayashi T, Sone H, et. al.
    • Journal Title

      Circ J 72

      Pages: 218-225

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Cross-sectional association between BMI, glycemic control and energy intake in Japanese patients with type 2 diabetes Analysis from the Japan Diabetes Complications Study.2008

    • Author(s)
      Sone, H, et. al.
    • Journal Title

      Diabetes Res Clin Pract 77 Suppl1

      Pages: 23-29

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cigarette Smoking Is Associated With low Glomerular filtration Rate in Male Patients With Type 2 Diabetes2007

    • Author(s)
      Saito K, Sone H, Yamada N.
    • Journal Title

      Diabetes Care 30

      Pages: e 2

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Meta-analysis: Effect of Aerobic Exercise Training on Serum Levels of High Density Lipoprotein Cholesterol.2007

    • Author(s)
      Kodama S, Sone H, et. al.
    • Journal Title

      Arch Intern Med 167

      Pages: 999-1008

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Risk imparted by various parameters of smoking in Japanese men with type 2 diabetes on their develoment of microalbuminuria: Analysis from the Tsukuba Kawai Diabetes Registry.2007

    • Author(s)
      Saito K, Sone H, et. al.
    • Journal Title

      Diabetes Care 30

      Pages: 1286-1288

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Cross-sectional association between BMI, glycemic control and energy intake in Japanese patients with type 2 diabetes Analysis from the Japan Diabetes Complications Study2007

    • Author(s)
      Sone H, et. al.
    • Journal Title

      Diabetes Res Clin Pract 77 Suppll

      Pages: S23-29

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Even low-intensity and low-volume exercise training may improve insulin resistance in the elderly.2007

    • Author(s)
      Kodama S, Sone H, et. al.
    • Journal Title

      Internal Medicine 46

      Pages: 1071-1077

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Crucial role of a long-chain fatty acid elongase, Elov16, in obesity-induced insulin resistance2007

    • Author(s)
      Matsuzaka T, Shimano H, Sone H, et. al.
    • Journal Title

      Nat Med 13

      Pages: 1193-1202

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] The regulation of adiponectin receptors expression by acute exercise in mice.2007

    • Author(s)
      Huang H, Iida KT, Sone H, Ajisaka R.
    • Journal Title

      Exp Clin Endocrinol Diabetes 115

      Pages: 417-22

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Protein Kinase A suppresses SREBP-1c expression via phosphorylation of LXR in the liver.2007

    • Author(s)
      Yamamoto T, Shimano H, Sone H, et. al.
    • Journal Title

      J Biol Chem 282

      Pages: 11687-95

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Outcome of one-year of specialist care of patients with type 2 diabetes : a multi-center prospective survey (JDDM 2)2007

    • Author(s)
      Sone, H, et. al.
    • Journal Title

      Intern Med 45

      Pages: 589-97

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cigarette Smoking Is Associated With Low Glomerular Filtration Rate in Male Patients With Type 2 Diabetes.2007

    • Author(s)
      K, Saito, H, Sone, N., Yamada
    • Journal Title

      Diabetes Care 30

      Pages: 2

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Meta-analysis : Effect of Aerobic Exercise Training on Serum Levels of High Density Lipoprotein Cholesterol.2007

    • Author(s)
      Kodama, S, Sone, H, et. al.
    • Journal Title

      Arch Intern Med 167

      Pages: 999-1008

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Risk imparted by various parameters of smoking in Japanese men with type 2 diabetes on their development of microalbuminuria : Analysis from the Tsukuba Kawai Diabetes Registry.2007

    • Author(s)
      Saito, K, Sone, H, et. al.
    • Journal Title

      Diabetes Care 30

      Pages: 1286-1288

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Even low-intensity and low-volume exercise training may improve insulin resistance in the elderly.2007

    • Author(s)
      Kodama, S, Sone, H, et. al.
    • Journal Title

      Internal Medicine 46

      Pages: 1071-1077

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Importance of Lipid Levels in Elderly Diabetic Individuals2007

    • Author(s)
      Hayashi, T, Sone, H, et. al.
    • Journal Title

      Circ J 72

      Pages: 218-225

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.2007

    • Author(s)
      Matsuzaka, T, Shimano, H, Sone, H, et. al.
    • Journal Title

      Nat Med 13

      Pages: 1193-1202

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The regulation of adiponectin receptors expression by acute exercise in mice.2007

    • Author(s)
      H, Huang, KT, Iida, H, Sone, R., Ajisaka
    • Journal Title

      Exp Clin Endocrinol Diabetes 115

      Pages: 417-22

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Protein Kinase A suppresses SREBP-lc expression via phosphorylation of LXR in the liver.2007

    • Author(s)
      Yamamoto, T, Shimano, H, Sone, H, et. al.
    • Journal Title

      J Biol Chem 282

      Pages: 11687-95

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cut Points of Waist Circumference.2006

    • Author(s)
      Sone H, et. al.
    • Journal Title

      Diabetes Care 29

      Pages: 1189

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Outcome of one-year of specialist care of patients with type 2 diabetes: amulti-center prospective survey(JDDM 2)2006

    • Author(s)
      Sone H, et. al.
    • Journal Title

      Intern Med 45

      Pages: 589-97

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Cut Points of Waist Circumference.2006

    • Author(s)
      Sone, H, et. al.
    • Journal Title

      Diabetes Care 29

      Pages: 1189

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Type 2 diabetes and its management in Japan2007

    • Author(s)
      Sone H
    • Organizer
      Seoul Diabetes Forum 2007
    • Place of Presentation
      韓国 ソウル
    • Year and Date
      2007-11-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Type 2 diabetes and its management in Japan2007

    • Author(s)
      H., Sone
    • Organizer
      Seoul Diabetes Forum 2007
    • Year and Date
      2007-11-24
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] シンポジウム「糖尿病網膜症-病態研究および治療の最前線-」2007

    • Author(s)
      曽根博仁
    • Organizer
      日本糖尿病合併症学会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2007-10-26
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Factors affecting remission of microalbuminuria in patients with type 2 diabetes2007

    • Author(s)
      Saito K, Sone H, et. al.
    • Organizer
      Japan-Korea Symposium on Diabetes Mellitus
    • Place of Presentation
      京都
    • Year and Date
      2007-10-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Low-fat diet may improve glycemic control in diabetic patients2007

    • Author(s)
      Kodama S, Sone H, et. al.
    • Organizer
      Japan-Korea Symposium on Diabetes Mellitus
    • Place of Presentation
      京都
    • Year and Date
      2007-10-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] No effect from low-carbohydrate diet on glycemic control in diabetic patients2007

    • Author(s)
      Kodama S, Sone H, et. al.
    • Organizer
      Japan-Korea Symposium on Diabetes Mellitus
    • Place of Presentation
      京都
    • Year and Date
      2007-10-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Factors affecting remission of microalbuminuria in patients with type 2 diabetes.2007

    • Author(s)
      Saito, K, Sone, H, et. al.
    • Organizer
      Japan-Korea Symposium on Diabetes Mellitus.
    • Year and Date
      2007-10-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Low-fat diet may improve glycemic control in diabetic patients2007

    • Author(s)
      Kodama, S, Sone, H, et. al.
    • Organizer
      Japan-Korea Symposium on Diabetes Mellitus.
    • Year and Date
      2007-10-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] No effect from low-carbohydrate diet on glycemic control in diabetic patients2007

    • Author(s)
      Kodama, S, Sone, H, et. al.
    • Organizer
      Japan-Korea Symposium on Diabetes Mellitus
    • Year and Date
      2007-10-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 日本人の血管合併症2007

    • Author(s)
      曽根博仁
    • Organizer
      日本糖尿病学会年次学術集会ランチョンセミナー
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Symposium of the Committee on the Treatment of Diabetes Mellitus.2007

    • Author(s)
      Sone H
    • Organizer
      Korea Diabetes Association
    • Place of Presentation
      韓国 ソウル
    • Year and Date
      2007-05-11
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Symposium of the Committee on the Treatment of Diabetes Mellitus.2007

    • Author(s)
      H., Sone
    • Organizer
      Korea Diabetes Association
    • Year and Date
      2007-05-11
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 井村臨床研究奨励賞受賞講演「2型糖尿病患者の血管合併症に関する国際臨床疫学的研究」2006

    • Author(s)
      曽根博仁
    • Organizer
      京都成人血管病シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2006-12-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 糖尿病-合併症の疫学. 「カラー版糖尿病学 基礎と臨床」(分担執筆)2007

    • Author(s)
      曽根博仁, 他
    • Total Pages
      682-686
    • Publisher
      西村書店
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 高脂血症からみた糖尿病とガイドラインの効果的活用.「糖尿病UP DATE」(分担執筆)2007

    • Author(s)
      曽根博仁, 他
    • Total Pages
      24-31
    • Publisher
      医歯薬出版
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 糖尿病とその合併症 「疾病の成り立ち II臓器別の病気」(分担執筆)2007

    • Author(s)
      曽根博仁, 他
    • Total Pages
      14-25
    • Publisher
      東京化学同人
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 糖尿病と虚血性心・脳血管疾患「脳・心血管イベントを防ぐための最新の知見とエビデンス」(分担執筆)2007

    • Author(s)
      曽根博仁, 他
    • Total Pages
      68-95
    • Publisher
      診断と治療社
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-02-04  

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