2007 Fiscal Year Final Research Report Summary
Evaluation of adipocytokine for the preventunof metabolic syndrome
| Project/Area Number |
18500541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Osaka University |
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Principal Investigator |
TAKIHARA Keiko Osaka University, Health Care Center, Associate Professor (70252640)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Cytokine / Obesity / Metabolic syndrome / Inflammation / Visceral fat / Atherosclerosis |
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| Research Abstract |
Since visceral fat tissue is known to release various pro- and anti-inflammatory cytokines, abdominal obesity may play a key role in the inflammation associated with metabolic syndrome (MetS). However, few studies have determined precise relationships of abdominal obesity with inflammatory markers in MetS. This study elucidated the significance of abdominal obesity on the inflammatory network in MetS in apparently healthy subjects.
Subjects with abdominal obesity (waist circumference ≧ 85 cm) showed higher serum hs-CRP and IL-6 levels and a lower adiponectin level than those without abdominal obesity. Serum levels of hs-CRP and IL-6 significantly increased in association with clustering of MetS components in the subjects with abdominal obesity, but not in those without abdominal obesity. Significant negative correlation between adiponectin and hs-CRP was observed in the subjects with abdominal obesity, however this correlation was not detected in obese subjects defined by body mass inde
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x ≧ 25. Therefore, inflammatory status is not exaggerated by clustering of MetS components in the subjects without abdominal obesity.
In the next series of the study, we evaluated the relative contribution of inflammation and MetS on subclinical atherosclerosis in healthy subjects. Increase in number of clustering MetS components was more clearly associated with worsening of carotid intima-media thickness (IMT) and pulse wave velocity (PWV) in women than in men. Serum IL-6 level was positively correlated with IMT and PWV, and adiponectin level was negatively correlated with IMT in men but not in women. The subjects either with a "high" IL-6 or hs-CRP, or a "low" adiponectin were associated with increase in IMT in the presence of MetS, though there was no significant effect of MetS in those with low inflammation. Components of MetS present profound effects on early arterial alterations in women rather than in men. While serum IL-6 and adiponectin levels are important factors for these alterations in men.
To summarize, abdominal obesity may exhibit distinct effect on pro- and anti-inflammatory proteins and modulate inflammatory network in MetS and exaggerate atherosclerosis. Less
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Author(s)
T., Higuchi, K., Yamauchi-Takihara, G., Hatsumiya, N., Fukushima, H., Ichikawa, T., Kuratani, Y., Maehata, Y., Sawa
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Journal Title
Ann Thorac Surg 82
Pages: 1367-1373
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Carbacyclin induces carnitine palmiloyltransferase-I in cardiomyocytes via peroxisome proliferator-activated receptor (PPAR) o independent of the IP receptor signaling pathway2007
Author(s)
T., Kuroda, I., Masaki, S., Sugiyama, Y., Hiramoto, Y., Fujio, H., Hirota, M., Hori, K., Yamauchi-Takihara
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Journal Title
J Mol Cell Cardial 43
Pages: 54-62
Description
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[Journal Article] Effects of IL-6, adiponectin, CRP and metabolic syndrome on subclinical atherosclerosis2007
Author(s)
M., Nishida, T., Moriyama, K., Ishii, S., Takashima, K., Yoshizaki, Y., Sugita, K., Yamauchi-Takihara
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Journal Title
Clin Cblm Acta 384
Pages: 99-104
Description
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[Journal Article] Stat3 is involved in cell growth and survival of human rbabdomyosarcoma and osteosarcoma cells2007
Author(s)
CL., Chen, A., Loy, FC., Hsieh, G., Cheng, B., Wu, SJ., Qualman, BM., Hall, K., Kunisada, K., Yamaucbi-Takihara, J., Lin
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