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2007 Fiscal Year Final Research Report Summary

STUDY ON THE DEVELOPMENT OF THE SCORE AS AN INDEX FOR THE EEFECT OF POLYPHENOL-CONTAINING FOODS ON THE REDUCTION OF BLOOD GLUCOSE LEVEL

Research Project

Project/Area Number 18500627
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionOkayama Prefectural University

Principal Investigator

TSUJI Hideaki  Okayama Prefectural University, Faculty of Health and Welfare Science, Department of Nutritional Science, Professor (20093875)

Co-Investigator(Kenkyū-buntansha) HIEMORI Miki  Okayama Prefectural University, Faculty of Health and Welfare Science, Department of Nutritional Science, Assistant Professor (80326412)
Project Period (FY) 2006 – 2007
KeywordsPolyphenol / Bllod glucose / Food style-induced disease / α-glucosidase inhibition / Chlorogenic acid / Chlorogenic acid derivative / Catechin / Quercetin
Research Abstract

Life-style-induced disease is a critical social problem. Diabete is one of the life-style-induced diseases. The disease consists of two types, namely I-type which is dependent on insulin, and IItype, which is nondependent on insulin. The latter type accounts for more than 95% of total diabetic patients. In order to cure and prevent the omset of the insuline-nondependent, a drug such as Acalbose and functional foods including functional components such as wheat albumin, quava polyphenol and digestion-resitant polydextrose have been utilized At present, other functional components than the above-mentioned components are expected to be developed.
In order to establish an index assessing the effect of polyphenol-containing foods on reduction of blood glucose level, it is very important to elucidate the functional components in the foods responsible for the reduction of blood glucose level We carried out the investigation on polyphenol compounds in foods actively. Consequently, we found out chlorogenic acid as a functional components inducing the reduction of blood glucose level Furthermore, catechins and quercetin were shown to show the functionality inducing the reduction of blood glucose level o among the known polyphenol compounds. Interestingly, these polyphenol components were shown to exhibit the regulation of the blood glucose level by inhibition α-glucosidase activity such as sucrase and maltase.
We found out the occurrence of chlorogenic acid derivatives in the leavers of white sweet potato called Kibimidori in Okayama region. These chlorogenic acid derivatives were shown to show more powerful inhibitory activity for α-glucosidase activity than chlorogenic acid, quecetin and catechins. This finding indicates that these components are candidate as afunctional components responsible for the reduction of blood glucose level.

  • Research Products

    (5 results)

All 2007 2006

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Characterization of inhibitors of postprandial hyperglycemia from the leaves of Nerium indicum2007

    • Author(s)
      A.Ishikawa, H.Yamamshita, M.Hiemori, E.Inagaki, M.Kimoto, M.Okamoto、 H.Tsuji, A.N.Memon, A.Mohammadi and Y.Natori,
    • Journal Title

      Journal of Nutritional Science and Vitaminology Vol.53

      Pages: 166-173

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Characterization of inhibitors of postprandial hyperglycemia from the leaves of Nerium indicum2007

    • Author(s)
      A. Ishikawa, H. Yamamshita, M. Hiemori, E. Inagaki, M. Kimoto, M. Okamoto, H. Tsuji, A.N. Memon, A. Mohammadi, Y. Natori
    • Journal Title

      J. Nutr. Sci. Vitaminol Vol. 53, No. 2

      Pages: 166-173

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Isolation and characterization of antiglycemic polyphenol components.in plant leaves2007

    • Author(s)
      A. Ishikawa, H. Yamashita, M. Hiemori, M. Kimoto, H. Tsuji
    • Organizer
      3rd International Conference on Polyphenols and Health, Satellite Sympojium in Kagoshima -Foods and Health in Asia
    • Year and Date
      20071123-24
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 外来植物におけるポリフェノール化合物の単離及びその機能性について2006

    • Author(s)
      石川 顕子、山下 広美、比江 森美樹、木本 眞順美、辻 英明
    • Organizer
      日本農芸化学会中四国支部会大会第16回講演会
    • Place of Presentation
      松山
    • Year and Date
      20060916-17
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Characterization of inhibitors of postprandial hyperglycemia2006

    • Author(s)
      Y. Natori, A. Ishikawa, H. Yamashita, M. Hiemori, H. Tsuji
    • Organizer
      10th International sympojium on natural product chemistry
    • Year and Date
      2006-01-06
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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