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2007 Fiscal Year Final Research Report Summary

A new dietary approach for prevertion of osteoporosis -osteogenic functions of plant foods-

Research Project

Project/Area Number 18500639
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionNakamura Gakuen College

Principal Investigator

TSUDA Hiroko  Nakamura Gakuen College, Dept. of Nutritional Sciences, Professor (30180003)

Co-Investigator(Kenkyū-buntansha) IMAI Katsumi  Nakamura Gakuen University, Dept. of Nutritional Sciences, Associate Professor (60203288)
NAKAZONO Eri  Nakamura Gakuen University, Dept. of Nutritional Sciences, Assistant (10343732)
Project Period (FY) 2006 – 2007
Keywordshealth and diet / osteoporosis / plant-derived isoplenoid
Research Abstract

1. Basic study
The water-extracts of a newly developed vegetable, petit vert, was found to increase the mRNA expression of BMP and osteoprotegerin of the human osteoblast cell line. In addition, we found gallic acid, a polyphenol derived from hydrolyzable tannin which is rich in vegetables and tea, enhanced the alkaline phosphatase activity, an osteoblat-differentiation marker. By using an animal model of impaired osteogenesis developed by feeding weanling rats with a Ca-deficient diet for 4weeks, a plant-derived monoterpene, geraniol, was found to improve the micro-architecture of trabecular bone of the distal part of femur and lower the serum levels of parathyroid hormone and CTX, a bone absorption marker.
2. Clinical study
The calcaneus osteo sono assessment index (OSI) of 297 female students, ranging in age from 18 to 22 years, were found to be decreased with age. Body weight, BMI, age at menarche, exercise, and intakes of energy, lipid and carbohydrate correlated with the OSI at the age of 21 but not with the reduction rate of OSI during 4 years ( Δ OSI), whereas Δ BMI correlated with Δ OSI but not with the OSI at the age of 21. The habit of skipping breakfast negatively correlated with both A OSI and the OSI at the age of 21. Among 179 adult obese women, postmenopausal women showed significantly decreased levels of OSI and increased levels of abdominal visceral fat area (VFA), total cholesterol and LDL cholesterol as compared with premenopausal women. Although the OSI levels in premenopausal women positively correlated with body weight, BMI, abdominal subcutaneous fat area (SFA), and leptin, those in premenopausal women did not. Abdominal SFA of postmenopausal women negatively correlated with total cholesterol and LDL cholesterol after adjustment for age and VFA.

  • Research Products

    (24 results)

All 2008 2007 2006 Other

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (12 results) Book (4 results)

  • [Journal Article] Subcutaneous fat accumulation shows a beneficial correlation with serum cholesterol in postmenopausal Japanese women2007

    • Author(s)
      Tanaka Misuzu
    • Journal Title

      Exp.Biol.Med.(Maywood) 232

      Pages: 1064-1070

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Subcutaneous fat accumulation shows a beneficial correlation with serum cholesterol in postmenopausal Japanese women.2007

    • Author(s)
      Tanaka M., Koga R., Tsuda H., lmai K., Abe S., Masuda T., Iwamoto M., Nakazono E., Kamohara T., Kinukawa N., Sakata T.
    • Journal Title

      Exp. Biol. Med (Maywood) 232(8)

      Pages: 1064-1070

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Characterization of endoplasmic reticulum-associated degradation of aprotein S mutant identified in a family of quantitative protein S deficiency2006

    • Author(s)
      Tsuda Hiroko
    • Journal Title

      Thromb.Res. 117・3

      Pages: 323-331

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] 中年女性の骨密度,骨吸収マーカーと身体状況,生活習慣との関連2006

    • Author(s)
      境 美樹
    • Journal Title

      Osteoporosis Jpn. 14・1

      Pages: 119-128

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Characterization of endoplasmic reticulum-associated degradation of a protein S2006

    • Author(s)
      Tsuda H., Tokunaga F., Nagamitsu H., KoideT.
    • Journal Title

      Thromb. Res. 117(3)

      Pages: 323-331

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The relation of bone mineral density and bone resorption marker with physical status and lifestyle factors in pre- and postmeriopausal women.2006

    • Author(s)
      Sakai M., Torimi Y., Harada C., Nakazono E., Shinndo N., Matsuo H., Takayanagi R., Tsuda H.
    • Journal Title

      Osteoporosis Jpn.(in Japanese) 14(1)

      Pages: 119-128

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Daily exercise fluctuations and dietary patterns during training predict visceral fat regain in obese women

    • Author(s)
      Koga Ririko
    • Journal Title

      Am.J.Med.Sci. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Daily exercise fluctuations and dietary patterns during training predict visceral fat regain in obese women.

    • Author(s)
      Koga R., Tanaka M., Tsuda F-I., Imai K., Abe S., Masuda T., Iwamoto M., Nakazono E., Kamohara T., Kinukawa N., Sakata T.
    • Journal Title

      Am. J. Med. Sd. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Ca欠乏成長期ラットの骨形成に対する植物モノテルペンの影響2008

    • Author(s)
      磯野 秀史
    • Organizer
      第11回日本病態栄養学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-01-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 肥満女性の腹部脂肪分布が音響的骨評価値に及ぼす影響2007

    • Author(s)
      津田 博子
    • Organizer
      第29回日本臨床栄養学会総会
    • Place of Presentation
      京都
    • Year and Date
      2007-11-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 植物エストロゲンは肝細胞のProtein S発現に影響を与える2007

    • Author(s)
      廣戸 美絵
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      三重
    • Year and Date
      2007-11-17
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] ストレス負荷による安静時エネルギー消費量の変化2007

    • Author(s)
      蒲原 朋子
    • Organizer
      第54回日本栄養改善学会
    • Place of Presentation
      長崎
    • Year and Date
      2007-09-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Phytoestrogens down-regulate protein S expression in HepG2 cells2007

    • Author(s)
      Tsuda Hiroko
    • Organizer
      XXIth Congr.Int.Soc.Thromb.Haemost
    • Place of Presentation
      Geneva
    • Year and Date
      2007-07-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Phytoestrogens down-regulate protein S expression in HepG2 cells.2007

    • Author(s)
      Tsuda H., Tadokoro K., Hiroto Y., Kishikawa M., Nakazono E.
    • Organizer
      XXIth Congr. Int. Soc. Thromb. Haemost.
    • Place of Presentation
      Geneva
    • Year and Date
      2007-07-10
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] geraniolによる低Ca投与成長期ラットの骨形成への影響2007

    • Author(s)
      中園 栄里
    • Organizer
      第61回日本栄養・食糧学会大会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] resvelatrol,genistein,daidzeinによる肝細胞の血液凝固制御因子protein S発現への影響2007

    • Author(s)
      田所 加奈
    • Organizer
      第61回日本栄養・食糧学会大会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 内臓脂肪量増減を規定する生活習慣因子の抽出2006

    • Author(s)
      古賀 里利子
    • Organizer
      第27回日本肥満学会
    • Place of Presentation
      神戸
    • Year and Date
      2006-10-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 脂質代謝に及ぼす腹部皮下脂肪の臨床的意義-閉経前後の比較-2006

    • Author(s)
      田中 美鈴
    • Organizer
      第27回日本肥満学会
    • Place of Presentation
      神戸
    • Year and Date
      2006-10-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 身体計測による高齢者の栄養アセスメント2006

    • Author(s)
      蒲原 朋子
    • Organizer
      第53回日本栄養改善学会
    • Place of Presentation
      つくば
    • Year and Date
      2006-10-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 植物モノテルペンは骨芽細胞のBMP-2,OPG,MGP発現に影響を与える2006

    • Author(s)
      山口 孝治
    • Organizer
      第60回日本栄養・食糧学会大会
    • Place of Presentation
      静岡
    • Year and Date
      2006-05-21
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Nブックス・応用栄養学[第4版]2007

    • Author(s)
      津田 博子
    • Total Pages
      1-12,161-181
    • Publisher
      建帛社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] わかりやすい臨床栄養学2007

    • Author(s)
      今井 克己
    • Total Pages
      91-109,159-173
    • Publisher
      三共出版
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 疾病の成因・病態・診断・治療2007

    • Author(s)
      津田 博子
    • Total Pages
      136-139
    • Publisher
      医歯薬出版株式会社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Nブックス・応用栄養学[第3版]2006

    • Author(s)
      津田 博子
    • Total Pages
      1-11,151-172
    • Publisher
      建帛社
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-02-04  

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