Delayed effects of prenatal exposure to methylmercury on nervous system and physiological aging

2008 Fiscal Year Final Research Report

• Project/Area Number: 18510029
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental impact assessment/Environmental policy
• Research Institution: National Institute for Minamata Disease
• Principal Investigator: SAKAMOTO Mineshi National Institute for Minamata Disease, 疫学研究部, 部長 (60344420)
• Co-Investigator(Kenkyū-buntansha): MURATA Katsuyuki 秋田大学, 医学部, 教授 (80157776)
• Project Period (FY): 2006 – 2008
• Keywords: メチル水銀 / 神経系 / 胎児曝露

Research Abstract

胎児期に受けたメチル水銀の加齢に伴って出現する後影響に関する研究は、重要な緊急課題である。そこで、我々は脳の発達時期にメチル水銀曝露を受けた患者における一定期間後において観察される影響について、疫学研究と動物実験により、神経生理学的、神経行動学的面から検討する。

Research Products

• [Journal Article] Changes in mercury concentrations of segmental maternal hair during gestation and their correlations with other biomarkers of fetal exposure to methylmercury in the Japanese population (2008)
  • Author(s): Sakamoto M, Kubota M, Murata K, Nakai K, Sonoda I, Satoh H
  • Journal Title: Enviro Res (106) Pages: 207-276
  • Peer Reviewed
• [Journal Article] Prenatal Methylmercury Exposure: Effects on Stress Response During Active Learning (2008)
  • Author(s): Maria Rosaria Carratu, Addolorata Coluccia, Antonella M. E. Modafferi, Pietro Borracci, Sergio Scaccianoce, Mineshi Sakamoto and Vincenzo Cuomo
  • Journal Title: Bulletin of Environmental Contamination and Toxicology (37) Pages: 3-8
  • Peer Reviewed
• [Journal Article] Heavy metal contamination status of Japanese cranes (Grus japonensis) in east Hokkaido, Japan-extensive mercury pollution (2007)
  • Author(s): Teraoka H, Kumagai Y, Iwai H, Haraguchi K, Ohba T, Nakai K, Satoh H: Sakamoto M, Momose K, Masatomi H, Hiraga T
  • Journal Title: Environ Toxicl Chem (26) Pages: 307-312
  • Peer Reviewed
• [Journal Article] 有村公良胎児性水俣病患者の現在のActivity of Daily Living (ADL) 実態と15年前との比較およびコミュニケーション障害に関する研究 (2007)
  • Author(s): 劉 暁潔,坂本峰至,加藤たけ子,岡本美和
  • Journal Title: 日本衛生学会誌 (62) Pages: 905-910
  • Peer Reviewed
• [Presentation] 胎盤通過性・胎児移行と次世代影響 (2008)
  • Author(s): 坂本 峰至
  • Organizer: 生殖次世代影響研究企画シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20080800
• [Presentation] 環境エンリッチがラットの脳発達期のメチル水銀投与で起こした神経行動学的障害に及ぼす効果に関する研究 (2008)
  • Author(s): 坂本峰至, Ricardo Oliveira
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本
  • Year and Date: 20080300
• [Presentation] Effects of environmental enrichment on neurobehavioral deficits caused by methylmercury treatment during postnatal development of rats (2008)
  • Author(s): Mineshi Sakamoto, Ricardo Oliveila et al.
  • Organizer: 25th International Neurotoxicology Conference
  • Place of Presentation: Rochester, USA
  • Year and Date: 2008-10-14
• [Presentation] 妊婦の魚介類を介したメチル水銀摂取が胎児に与える影響とその評価 (2007)
  • Author(s): 坂本峰至
  • Organizer: 衛生薬学・環境トキシコロジー フォーラム2007金属をめぐる最近の話題
  • Place of Presentation: 大坂
  • Year and Date: 20071100
• [Presentation] Segmental hair mercury concentrations during gestation and correlations among baby hair, maternal blood and cord blood mercury levels at parturition (2007)
  • Author(s): Sakamoto M, Kubota M, Murata K, Nakai K, Satoh H
  • Organizer: International Conference on Fetal Programming and Development Toxicity
  • Place of Presentation: Torshavn, Faroe Islands
  • Year and Date: 20070500