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2008 Fiscal Year Final Research Report

Structure and Function of Weak Interaction in Blue Copper Protein

Research Project

  • PDF
Project/Area Number 18550147
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemistry related to living body
Research InstitutionIbaraki University

Principal Investigator

KOHZUMA Takamitsu  Ibaraki University, 理工学研究科, 教授 (50215183)

Co-Investigator(Kenkyū-buntansha) 鳥飼 直也  高エネルギー加速器研究機構, 物質構造科学研究所, 准教授 (70300671)
Project Period (FY) 2006 – 2008
Keywordsブルー銅タンパク質 / 弱い相互作用 / 電子移動反応
Research Abstract

ブルー銅タンパク質に配位するヒスチジンへの弱い相互作用の様式が変化する事によって、活性中心のCu(II)の電子状態が変化し、酸化還元電位などが顕著に変化することが見いだされた。この結果は、タンパク質複合体形成などにおける弱い相互作用が生理学的に意味の有る範囲において顕著に反応性を微調整することを示唆するものである。

  • Research Products

    (7 results)

All 2009 2008 2007 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Alkaline Transition of Pseudoazurin Met16X Mutant Proteins : Protein Stability Influenced by the Substitution of Met16 in the Second Sphere Coordination2008

    • Author(s)
      Rehab F. Abdelhamid, Yuji Obara, Takamitsu Kohzuma
    • Journal Title

      J. Inorg. Biochem. 102

      Pages: 1373-1379

    • Peer Reviewed
  • [Journal Article] π-π Interaction between Aromatic Ring and Copper Coordinated His81 Imidazole Regulates the Blue Copper Active Site Structure2007

    • Author(s)
      Rehab F. Abdelhamid, Yuji Obara, Yoshiko Uchida, Takamitsu Kohzuma, David M. Dooley, Doreen E. Brown, and Hiroshi Hori
    • Journal Title

      J. Biol. Inorg. Chem. 12

      Pages: 165-173

    • Peer Reviewed
  • [Journal Article] p-Interaction Tuning of the Active Site Properties of Metalloproteins

    • Author(s)
      Sachiko Yanagisawa, Peter B. Crowley, Susan J. Firbank, Anne T. Lawler, David M. Hunter, William McFarlane, Chan Li, Takamitsu Kohzuma, Mark J. Banfield, and Christopher Dennison
    • Journal Title

      J. Am. Chem. Soc.

    • Peer Reviewed
  • [Presentation] Perturbation of the Protein Electronic Structure through Weak Chemical Interaction2008

    • Author(s)
      Takamitsu Kohzuma
    • Organizer
      6th China-Japan Crossover Science Symposium(招待講演)
    • Place of Presentation
      Zhengzhou, China
    • Year and Date
      20081000
  • [Presentation] The role of 2nd coordination sphere in a blue copper protein, pseudoazurin2008

    • Author(s)
      Takamitsu Kohzuma, Rehab F. Abdelhamid, Yuji Obara
    • Organizer
      9th European Conference of Biological Chemistry, Broclow, Poland(招待講演)
    • Place of Presentation
      Poland
    • Year and Date
      20080900
  • [Presentation] UV Resonance Raman Spectroscopic Studies of Human Hematopoietic Prostaglandin D_2 Synthase, International Symposium on Biological Application of Vibrational Spectroscopy2007

    • Author(s)
      Takamitsu Kohzuma
    • Organizer
      International Symposium on Biological Application of Vibrational Spectroscopy, Center for Advanced Science and Technology, Hyogo(招待講演)
    • Place of Presentation
      Hyogo, Japan
    • Year and Date
      20070300
  • [Book] 元素111の新知識第2版2009

    • Author(s)
      桜井弘、荒野泰、上山憲一、小谷明、高妻孝光、佐治英郎、鈴木晋一郎、寺嶋孝仁、中山祐正、根矢三郎、廣田俊、藤井敏司、吉村哲彦
    • Total Pages
      461
    • Publisher
      講談社

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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