2007 Fiscal Year Final Research Report Summary
Fabrication of mobile SQUID for bio-mesurements
| Project/Area Number |
18560405
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Measurement engineering
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| Research Institution | Muroran Institute of Technology |
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Principal Investigator |
MATUDA Mizushi Muroran Institute of Technology, Faculty of Engineering, Electrical and Electronic Engineering, Professor (20261381)
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| Project Period (FY) |
2006 – 2007
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| Keywords | SQUID / Signal-noise ratio / Magnetic flux noise / Sensor array / Non destructive evaluation / 非破壊計測 |
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| Research Abstract |
Measurement of magnetic nanoparticles is a versatile technique to detect target molecules that are labeled with the magnetic particles in various bio-applications. Magnetic particles accumulated in organs can be a marker of certain diseases and the particles/molecules associated with antigen-antibody reaction are detected in immunoassay.
We are developing sensitive detection technique of magnetic nanoparticles based on ac-susceptibility measurement. We have developed a portable SQUID magnetometer for this purpose to measure the current that was detected with an induction coil. The SQUID magnetometer operates as a current meter having a resolution of 16 pA/Hz^<1/2>.
A capsule that. Contained super-paramagnetic nanoparticles was inserted in a solenoid detection coil. A concentric excitation coil was situated around the detection coil. In its original design, two excitation fields of different frequencies are applied to the sample and a harmonic signal of difference frequency is detected^<1>. This is aimed to measure the ac susceptibility of super-paramagnetic particles having nonlinear field-magnetization curve. In this study we detected the third-order higher harmonic of the excitation frequency using a single excitation frequency, which simplified the detection system from the original type.
The harmonic signal was input as a current into the input coil of the SQUID magneto-meter and then coupled as the magnetic flux. The mutual inductance between the input coil and a high-Tc SQUID was 3 nH. As a result, a detection sensitivity of order of 10 ng of Fe_3O_4 particles was achieved at an excitation frequency of 509 Hz.
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[Presentation] バイオ計測のための交流帯磁率測定における検出コイルの検討2008
Author(s)
向舘健, 大上和哉, 李〓, 栗城眞也, 松田瑞史, 平野悟, SY. Yang, HE. Horng, HC. Yang
Organizer
第43回応用物理学会北海道支部/第4回日本光学会北海道支部合同学術講演会
Place of Presentation
札幌(北海道大学)
Year and Date
20080100
Description
「研究成果報告書概要(和文)」より
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[Presentation] SQUID nondestructive testing system with vibrating normal pick-up coil2006
Author(s)
(2) S. Hirano, Y. Inada, H. Kuroyanagi, K. Shibata, E. Matsumoto, A. Saito, K. Aizawa, S. Ohshima, M. Matsuda, and S. Kuriki
Organizer
Applied Superconductivity Conference
Place of Presentation
September, Seattle
Year and Date
20060000
Description
「研究成果報告書概要(欧文)」より
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