Analyses on the novel functions of the COP9 signalosome, a master regulator responding to environm ental stimuli

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 18570041
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 植物生理・分子
• Research Institution: Kyoto University
• Principal Investigator: TSUGE Tomohiko Kyoto University, Institute for Chemical Research, Assistant Professor (50291076)
• Project Period (FY): 2006 – 2007
• Keywords: signal transduction / photomorphogenesis / proteolysis / transcriptional regulation / plants / mRNA maturation / protein-protein interaction / environmental stimuli response

Research Abstract

We have previously reported that COP9 signalosome (CSN) regulates signal transduction by mediating proteolysis in the nuclei. We have also identified novel CSN1 function that does not involve proteolysis in its regulation. Here, we focused on identifying proteins that directly bind to the functional portion of the CSN1 protein, using the Arabidopsis system to investigate the novel regulation of CSN1. The findings are summarized below.
1. The putative CSN1-binding protein, SAP130 (spliceosome associated protein 130) was identified in a systematic pull-down using the functional domain of CSN1 as bait. In Arabidopsis, SAP130 was coded by two closely mapped genes, and its mRNA was detected in all of the tested organs. Plants harboring T-DNA insertions in the promoter or coding region of these genes did not display detectable changes. In attempt to analyze the loss-of-function and gain-of-function of these genes, we constructed transgenic plants that knock-down and over-express the two genes , by over-expression and by RNAi methods, together with an inducible system. Further analyses are in progress.
2. SAP130 was shown to directly bind CSN1 in both mammalian and plant systems. This binding was mediated through the N-terminal half of CSN1. Plants expressing mutations in this binding-interface have been created to reveal the endogenous nature of this binding. Furthermore we revealed that, SAP130 is homologous to DDB1, directly binds cullin subunit of Cullin-RING ubiquitin E3 ligases, and possess polyubiquitinating activity.
3. Since SAP130 has been identified in multiple complexes such as SF3b, STAGA, and TFTC, we tagged CSN1 and SAP130 with various fluorescence tags to investigate the localization patterns in detail, in combination with external stimuli. The proteins were dominantly detected in the nucleus and further analyses is in progress. These results have been reported through international and domestic conferences and through high-profiled international journal publications.

Research Products

• [Journal Article] Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome. (2008)
  • Author(s): Menon S, Tsuge T, Dohmae N, Takio K, Wei N.
  • Journal Title: BMC Biochemistry 9 Pages: 1
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The Arabidopsis phosphatidylinositol phosphate 5-kinase PIP5K3 is a key regulator for root hair tip growth. (2008)
  • Author(s): Kusano H, Testerink C, Vermeer JEM, Tsuge T, Shimada H, Oka A, Munnik T, Aoyama T.
  • Journal Title: The Plant Cell 20 Pages: 367-380
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] SPOROCYTELESS modulates YUCCA expression to regulate the development of lateral organs in Arabidopsis. (2008)
  • Author(s): Li L, Qin G, Tsuge T, Hou X, Ding M, Aoyama T, Oka A, Chen Z, Gu H, Zhao Y, Qu LJ.
  • Journal Title: The New Phytologist (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Targeted degradation of ICK4/KRP6 by the RING type E3 ligases RHF1a and RHF2a is essential for mitotic cell cycle progression during Arabidopsis gametogenesis. (2008)
  • Author(s): Liu J, Zhang Y, Qin G, Tsuge T, Sakaguchi N, Luo G, Sun K, Shi D, Aki S, Zheng N, Aoyama T, Oka A, Yang W, Umeda M, Xie Q, Gu H, Qu LJ.
  • Journal Title: The Plant Cell (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The possible action mechanisms of indole-3-acetic acid methyl ester in Arabidopsis (2008)
  • Author(s): Li, L., Hou, X., Tsuge, T., Ding, M., Aoyama, T., Oka, A., Gu, H., Zhao, Y., Qu, LJ
  • Journal Title: Plant Cell Reports 27 Pages: 575-584
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome (2008)
  • Author(s): Menon, S., Tsuge, T., Dohmae, N., Takio, K., Wei, N
  • Journal Title: BMC Biochemistry 9 Pages: 1
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The Arabidopsis phosphatidylinositol phosphate 5-kinase PIP5K3 is a key regulator for root hair tip growth (2008)
  • Author(s): Kusano, H., Testerink, C., Vermeer, JEM., Tsuge, T., Shimada, H., Oka, A., Munnik, T., Aoyama, T
  • Journal Title: The Plant Cell 20 Pages: 367-380
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] SPOROCYTELESS modulates YUCCA expression to regulate the development of lateral organs in Arabidopsis (2008)
  • Author(s): Li, L., Qin, G., Tsuge, T., Hou, X., Ding, M., Aoyama, T., Oka, A., Chen, Z., Gu, H., Zhao, Y., Qu, LJ
  • Journal Title: The New Phytologist (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Targeted degradation of ICK4/KRP6 by the RING type E3 ligases RHF1a and RHF2a is essential for mitotic cell cycle progression during Arabidopsis gametogenesis (2008)
  • Author(s): Liu, J., Zhang, Y., Qin, G., Tsuge, T., Sakaguchi, N., Luo, G., Sun, K., Shi, D., Aki, S., Zheng, N., Aoyama, T., Oka, A., Yang, W., Umeda, M., Xie, Q., Gu, H., Qu, LJ
  • Journal Title: The Plant Cell (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mammalian DET1 regulates Cu14A activity and forms stable complexes with E2 ubiquitin conjugating enzymes. (2007)
  • Author(s): Pick E, Lau OS, Tsuge T, Menon S, Tong Y, Dohmae N, Plafker S, Deng XW, Wei N.
  • Journal Title: Molecular and Cellular Biology 27 Pages: 4708-4719
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] ARR1 directly activates cytokinin response genes that encode proteins with diverse regulatory functions. (2007)
  • Author(s): Taniguchi M, Sasaki N, Tsuge T, Aoyama T, Oka A.
  • Journal Title: Plant & Cell Physiology 48 Pages: 263-277
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A calmodulin-binding mitogen-activated protein kinase phosphatase is induced by wounding and regulates the activities of stress-related mitogen-activated protein kinases in rice. (2007)
  • Author(s): Katou S, Kuroda K, Seo S, Yanagawa Y, Tsuge T, Yamazaki M, Miyao A, Hirochika H, Ohashi Y.
  • Journal Title: Plant & Cell Physiology 48 Pages: 332-344
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The possible action mechanisms of indole-3-acetic acid methyl ester in Arabidopsis. (2007)
  • Author(s): Li L, Hou X, Tsuge T, Ding M, Aoyama T, Oka A, Gu H, Zhao Y, Qu LJ.
  • Journal Title: Plant Cell Reports 27 Pages: 575-584
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin conjugating enzymes (2007)
  • Author(s): Pick, E., Lau, OS., Tsuge, T., Menon, S., Tong, Y., Dohmae, N., Plafker, S., Deng, XW., Wei, N
  • Journal Title: Molecular and Cellular Biology 27 Pages: 4708-4719
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] ARR1 directly activates cytokinin response genes that encode proteins with diverse regulatory functions (2007)
  • Author(s): Taniguchi, M., Sasaki, N., Tsuge, T., Aoyama, T., Oka, A
  • Journal Title: Plant & Cell Physiology 48 Pages: 263-277
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A calmodulin-binding mitogen-activated protein kinase phosphatase is induced by wounding and regulates the activities of stress-related mitogen-activated protein kinases in rice (2007)
  • Author(s): Katou, S., Kuroda, K., Seo, S., Yanagawa, Y., Tsuge, T., Yamazaki, M., Miyao, A., Hirochika, H., Ohashi, Y
  • Journal Title: Plant & Cell Physiology 48 Pages: 332-344
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The ubiquitin regulation in photomorphogenesis (2006)
  • Author(s): Tsuge, T
  • Journal Title: "Tanpakushitu Kakusan Koso", Kyoritsu, Tokyo 51, 10 Suppl Pages: 1352-1357
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The unique auxin perception by SCF-mediated pathways (2006)
  • Author(s): Tsuge, T
  • Journal Title: "Tanpakushitu Kakusan Koso", Kyoritsu, Tokyo 51, 10 Suppl Pages: 1358
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Shoot-The architecture of plant module (2006)
  • Author(s): Tsuge, T., Tsukaya, H
  • Journal Title: Plantmimetics-learning from plants", NTS, Tokyo Pages: 4-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] COP9シグナロソームとmRNA代謝関与因子との相互作用を介した新たな制御機構 (2008)
  • Author(s): 安喜史織、片岡麻由子、谷口雅俊、堂前直、MENON Suchithra、WEI Ning、岡穆宏、柘植知彦
  • Organizer: 第49回日本植物生理学会年会
  • Place of Presentation: 札幌コンベンションセンター、北海道札幌市
  • Year and Date: 20080320-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] リン酸欠乏下におけるシロイヌナズナ・ホスホリパーゼ(PLDz2)の機能解析 (2008)
  • Author(s): 谷口幸美、柘植知彦、岡穆宏、青山卓史
  • Organizer: 第49回日本植物生理学会年会
  • Place of Presentation: 札幌コンベンションセンター、北海道札幌市
  • Year and Date: 20080320-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] COP9 Signalosome: The key modulator of signal transduction in plants and mammals. (2008)
  • Author(s): Tsuge T
  • Organizer: Joint Forum for the "Executive Program of Cooperation in the Fields of Science & Technology between the Government of Italy and the Government of Japan for the Period from 2008 to 2009"
  • Place of Presentation: University of Rome"La Sapienza", Rome, ITALY
  • Year and Date: 20080306-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] COP9 Signalosome : The key modulator of signal transduction in plants and mammals (2008)
  • Author(s): Tsuge, T
  • Organizer: Joint Forum for the "Executive Program of Cooperation in the Fields of Science&Technology between the Government of Italy and the Government of Japan for the Period from 2008 to 2009"
  • Place of Presentation: University of Rome "La Sapienza", Rome, ITALY
  • Year and Date: 20080306-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] COP9 signalosome interacts with RNA processing factors in Arabidopsis. (2007)
  • Author(s): Aki S, Oka A, Tsuge T
  • Organizer: 18th International Conference on Arabidopsis Research
  • Place of Presentation: Jiuhua Resort & Convention Center, Beijing, CHINA
  • Year and Date: 20070620-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] COP9 signalosome interacts with RNA processing factors in Arabidopsis (2007)
  • Author(s): Aki, S., Oka, A., Tsuge, T
  • Organizer: 18th International Conference on Arabidopsis Research
  • Place of Presentation: Jiuhua Resort & Convention Center, Beijing, CHINA
  • Year and Date: 20070620-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The DDB1-like protein SAP130/SF3b-3 is a cullin binding protein, and is regulated by the neddylation pathway. (2007)
  • Author(s): Menon S, Tsuge T, Dohmae N, Takio K, Wei N.
  • Organizer: The Ubiquitin family-Cold Spring Harbor Laboratory Meeting
  • Place of Presentation: Cold Spring Harbor Laboratory, Cold Spring Harbor, NY USA
  • Year and Date: 20070425-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The DDB1-like protein SAP130/Sf3b-3 is a cullin binding protein, and is regulated by the neddylation pathway (2007)
  • Author(s): Menon, S., Tsuge, T., Dohmae, N., Takio, K., Wei, N
  • Organizer: The Ubiquitin family-Cold Spring Harbor Laboratory Meeting
  • Place of Presentation: Cold Spring Harbor Laboratory, Cold Spring Harbor, NY USA
  • Year and Date: 20070425-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] COP9シグナロソームのタンパク質分解と新規制御機構 (2007)
  • Author(s): 柘植知彦、安喜史織、谷口雅俊、堂前直、MENON Suchithra、PICK Elah、WEI Ning、岡穆宏
  • Organizer: 第48回日本植物生理学会年会
  • Place of Presentation: 愛媛大学、愛媛県松山市
  • Year and Date: 20070328-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] COP9シグナロソームとSAP130の相互作用の機能解析 (2007)
  • Author(s): 安喜史織、岡穆宏、柘植知彦
  • Organizer: 第48回日本植物生理学会年会
  • Place of Presentation: 愛媛大学、愛媛県松山市
  • Year and Date: 20070328-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Identifying novel regulation beyond proteolysis of the COP9 signalosome (2007)
  • Author(s): Tsuge, T., Aki, S., Taniguchi, M., Dohmae, N., Menon, S., Pick, E., Wei, N., Oka, A
  • Organizer: The 48th Annual meeting of The Japanese Society of Plant Physiologists
  • Place of Presentation: Ehime University, Matsuyama, JAPAN
  • Year and Date: 20070328-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Arabidopsis CSN1 binds SAP130, a component of the mRNA splicing machinery (2007)
  • Author(s): Aki, S., Oka, A., Tsuge, T
  • Organizer: The 48th Annual meeting of The Japanese Society of Plant Physiologists
  • Place of Presentation: Ehime University, Matsuyama, JAPAN
  • Year and Date: 20070328-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Identifying novel regulation through the association of mRNA processing factors and COP9 signalosome (2007)
  • Author(s): Aki, S., Kataoka, M., Taniguchi, M., Dohmae, N., Menon, S., Wei, N, Oka, A., Tsuge, T
  • Organizer: The 49th Annual meeting of The Japanese Society of Plant Physiologists
  • Place of Presentation: Sapporo Convention Center, Sapporo, JAPAN
  • Year and Date: 20070320-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Functional analysis of phospholipase Dz2 (PLDz2) under phosphate-starved condition in Arabidopsis thaliana (2007)
  • Author(s): Taniguchi, Y., Tsuge, T., Oka, A., Aoyama, T
  • Organizer: The 49th Annual meeting of The Japanese Society of Plant Physiologists
  • Place of Presentation: Sapporo Convention Center, Sapporo, JAPAN
  • Year and Date: 20070320-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ARR1 directly activates cytokinin response genes that encode proteins with diverse regulatory functions. (2007)
  • Author(s): Taniguchi M, Tsuge T, Aoyama T, Oka A.
  • Organizer: Trends in Plant Hormones, RIKEN Plant Science Center International Symposium
  • Place of Presentation: RIKEN Yokohama Institute, Kanagawa, JAPAN
  • Year and Date: 20070301-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ARR1 directly activates cytokinin response genes that encode proteins with diverse regulatory functions (2007)
  • Author(s): Taniguchi, M., Tsuge, T., Aoyama, T., Oka, A
  • Organizer: Trends in Plant Hormones, RIKEN Plant Science Center International Symposium
  • Place of Presentation: RIKEN Yokohama Institute, Yokohama, JAPAN
  • Year and Date: 20070301-02
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 光形態形成制御因子「COP9シグナロソーム」の制御機構 (2007)
  • Author(s): 柘植知彦
  • Organizer: 「LOV光受容体による植物の運動制御機構」第1回若手ワークショップ
  • Place of Presentation: 京都大学芝欄会館、京都府京都市
  • Year and Date: 20070117-18
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regulation of the COP9 signalosome, a repressor of photomorphogenesis (2007)
  • Author(s): Tsuge, T
  • Organizer: The 1st Workshop for Young Researchers-Scientific Research on Priority Areas "Plant Movement Regulation by LOV-domain Photoreceptors"
  • Place of Presentation: Shiran Hall Kyoto University, Kyoto, JAPAN
  • Year and Date: 20070117-18
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mammalian DET1 regulates CUL4A activity and forms stable complexes with ubiquitin E2 enzymes. (2007)
  • Author(s): Pick E, Lau OS, Tsuge T, Deng XW, Wei N
  • Organizer: The Annual Meeting of the Israel Society for Biochemistry & Molecular Biology
  • Place of Presentation: The Technion, Haifa, ISRAEL
  • Year and Date: 2007-08-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mammalian DET1 regulates CUL4A activity and forms stable complexes with ubiquitin E2 enzymes (2007)
  • Author(s): Pick, E., Lau, OS., Tsuge, T., Deng, XW., Wei, N
  • Organizer: The Annual Meeting of the Israel Society for Biochemistry & Molecular Biology
  • Place of Presentation: The Technion, Haifa, ISRAEL
  • Year and Date: 2007-08-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] COP9シグナロソームの新規制御メカニズムの解析 (2006)
  • Author(s): 柘植知彦、安喜史織、谷口雅俊、堂前直、Menon Suchithra、Pick Elah、Wei Ning、岡穆宏
  • Organizer: 日本分子生物学会2006フォーラム「分子生物学の未来」
  • Place of Presentation: 名古屋国際会議場、愛知県名古屋市
  • Year and Date: 20061206-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] COP9シグナロソーム サブユニット1(CSN1)とSAP130の相互作用解析 (2006)
  • Author(s): 安喜史織、岡穆宏、柘植知彦
  • Organizer: 日本分子生物学会2006フォーラム「分子生物学の未来」
  • Place of Presentation: 名古屋国際会議場、愛知県名古屋市
  • Year and Date: 20061206-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Novel regulation of COP9 Signalosome : the master regulator of signal transduction (2006)
  • Author(s): Tsuge, T., Ala, S., Taniguchi, M., Dohmae, N., Menon, S., Pick, E., Wei, N., Oka, A
  • Organizer: Molecular Biology Society of Japan 2006 Forum : Molecular Biology-the Next Decade
  • Place of Presentation: Nagoya Congress Center, Nagoya, JAPAN
  • Year and Date: 20061206-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Interaction studies of CSN1 and SAP130 (2006)
  • Author(s): Aki, S., Oka, A., Tsuge, T
  • Organizer: Molecular Biology Society of Japan 2006 Forum : Molecular Biology-the Next Decade.
  • Place of Presentation: Nagoya Congress Center, Nagoya, JAPAN
  • Year and Date: 20061206-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] COP9 Signalosome Subunit1 interacts with components of the transcription/RNA processing complexes. (2006)
  • Author(s): Tsuge T, Aki S, Taniguchi M, Dohmae N, Menon S, Pick E, Wei N, Oka A.
  • Organizer: ZOMES-IV The Fourth International Symposium on COP9 Signalosome, Proteasome, and eIF3
  • Place of Presentation: Yale University Campus, New Haven, CT USA
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regulation by the COP9 Signalosome of AtPIC2, a novel F-box protein from Arabidopsis thaliana. (2006)
  • Author(s): Iafrate S, Moubayidin L, Heyl A, Tsuge T, Deng XW, Costantino P, Serino G.
  • Organizer: ZOMES-IV The Fourth International Symposium on COP9 Signalosome, Proteasome, and eIF3
  • Place of Presentation: Yale University Campus, New Haven, CT USA
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Cullin Neddylation and functions of CSN1 and CSN8. (2006)
  • Author(s): Menon S, Pick E, Tsuge T, Dohmae N, Flavell R, Wei N.
  • Organizer: ZOMES-IV The Fourth International Symposium on COP9 Signalosome, Proteasome, and eIF3
  • Place of Presentation: Yale University Campus, New Haven, CT USA
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Human DET1 complexes contain canonical ubiquitin E2 enzymes and regulate CUL4A E3 activity. (2006)
  • Author(s): Pick E, Tsuge T, Tong Y, Menon S, Dohmae N, Deng XW, Wei N.
  • Organizer: ZOMES-IV The Fourth International Symposium on COP9 Signalosome, Proteasome, and eIF3
  • Place of Presentation: Yale University Campus, New Haven, CT USA
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] COP9 Signalosome Subunitl interacts with components of the transcription/RNA processing complexes. (2006)
  • Author(s): Tsuge, T., Aki, S., Taniguchi, M., Dohmae, N., Menon, S., Pick, E., Wei, N., Oka, A
  • Organizer: ZOMES-IV The Fourth International Symposium on COP9 Signalosome, Proteasome, and eIF3
  • Place of Presentation: Yale University, New Haven, CT USA
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regulation by the COP9 Signalosome of AtPIC2, a novel F-box protein from Arabidopsis thaliana (2006)
  • Author(s): Iafrate, S., Moubayidin, L., Heyl, A., Tsuge, T., Deng, XW., Costantino, P., Serino, G
  • Organizer: ZOMES-IV The Fourth International Symposium on COP9 Signalosome, Proteasome, and eIF3
  • Place of Presentation: Yale University, New Haven, CT USA
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Cullin Neddylation and functions of CSN1 and CSN8 (2006)
  • Author(s): Menon, S., Pick, E., Tsuge, T., Dohmae, N., Flavell, R., Wei, N
  • Organizer: ZOMES-IV The Fourth International Symposium on COP9 Signalosome, Proteasome, and eIF3
  • Place of Presentation: Yale University, New Haven, CT USA
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Human DET1 complexes contain canonical ubiquitin E2 enzymes and regulate CUL4AE3 activity (2006)
  • Author(s): Pick, E., Tsuge, T., Tong, Y., Menon, S., Dohmae, N., Deng XW., Wei, N
  • Organizer: ZOMES-IV The Fourth International Symposium on COP9 Signalosome, Proteasome, and eIF3
  • Place of Presentation: Yale University, New Haven, CT USA
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regulation by the COP9 Signalosome of PIC2, a novel F-box protein from Arabidopsis thaliana. (2006)
  • Author(s): Moubayidin L, Iafrate S, Tsuge T, Heyl A, Deng XW, Costantino P, Serino G.
  • Organizer: 3rd EPSO Conference '06 "Plant Dynamics: from Molecules to Ecosystems"
  • Place of Presentation: Thermal Hotel, Visegrad, HUNGARY
  • Year and Date: 20060528-0601
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regulation by the COP9 Signalosome of PIC2, a novel F-box protein from Arabidopsis thaliana (2006)
  • Author(s): Moubayidin, L., Iafrate, S., Tsuge, T., Heyl, A., Deng, XW., Costantino, P., Serino, G
  • Organizer: 3rd EPSO Conference '06 "Plant Dynamics : from Molecules to Ecosystems"
  • Place of Presentation: Thermal Hotel, Visegrad, HUNGARY
  • Year and Date: 20060528-0601
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] COP9シグナロソームの新規制御機構 (2006)
  • Author(s): 安喜史織、岡穆宏、柘植知彦
  • Organizer: 第106回化学研究所研究発表会
  • Place of Presentation: 京都大学化学研究所、京都府宇治市
  • Year and Date: 2006-12-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The novel function of COP9 signalosome regulation (2006)
  • Author(s): Aki, S., Oka, A., Tsuge, T
  • Organizer: The 106th Institute for Chemical Research Annual Symposium
  • Place of Presentation: Kyoto University, Uji, JAPAN
  • Year and Date: 2006-12-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] COP9 Signalosome: the key modulator of signal transduction in plants and mammals. (2006)
  • Author(s): Tsuge T.
  • Organizer: Invited lecture at POSTECH(Pohang University of Science and Technology), Biotech Center.
  • Place of Presentation: POSTECH, Pohang KOREA
  • Year and Date: 2006-11-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] COP9 Signalosome : the key modulator of signal transduction in plants and mammals (2006)
  • Author(s): Tsuge, T
  • Organizer: Invited lecture at POSTECH (Pohan m,9 87g University of Science and Technology), Biotech Center
  • Place of Presentation: POSTECH, Pohang, KOREA
  • Year and Date: 2006-11-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] COP9 Signalosome: the key modulator of signal transduction in plants and mammals. (2006)
  • Author(s): Tsuge T.
  • Organizer: Invited lecture at the International Symposium on Biotechnological Approaches for Agriculture and Medicine.
  • Place of Presentation: Nam Tae Pyung Yang Hotel, Busan KOREA
  • Year and Date: 2006-11-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] COP9 Signalosome : the key modulator of signal transduction in plants and mammals (2006)
  • Author(s): Tsuge, T
  • Organizer: Invited lecture at the International Symposium on Biotechnological Approaches for Agriculture and Medicine
  • Place of Presentation: Nam Tae Pyung Yang Hotel, Busan, KOREA
  • Year and Date: 2006-11-02
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 植物のモジュールと配置・シュート, 「プラントミメティクッス-植物に学ぶ-」, 甲斐昌一・森川弘道(監修) (2006)
  • Author(s): 柘植知彦, 塚谷裕一
  • Total Pages: 4-10
  • Publisher: エヌ・ティー・エス 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Book] オーキシン受容体の発見-植物ホルモンが制御するSCF型ユビキチンリガーゼ-, 「蛋白質 核酸 酵素」8月号増刊「ユビキチン・プロテアソーム系とオートファジー」, 田中啓二・大隈良典(編) (2006)
  • Author(s): 柘植知彦
  • Total Pages: 51:No.10,1358
  • Publisher: 共立出版 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 植物の光形態形成とユビキチン, 「蛋白質 核酸 酵素」8月号増刊「ユビキチン・プロテアソーム系とオートファジー」, 田中啓二・大隈良典(編) (2006)
  • Author(s): 柘植知彦
  • Total Pages: 51:No.10,1352-1357
  • Publisher: 共立出版 東京
  • Description: 「研究成果報告書概要(和文)」より