2007 Fiscal Year Final Research Report Summary
Central action of proteinacious hormones
Project/Area Number |
18570063
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Morphology/Structure
|
Research Institution | Waseda University |
Principal Investigator |
KIKUYAMA Sakae Waseda University, Faculty of Education and Integrated Arts and Sciences, Professor Emeritus (20063638)
|
Co-Investigator(Kenkyū-buntansha) |
TOYODA Fumiyo Nara Medical University, Faculty of Medicine, Lecturer (10244708)
HASUNUMA Itaru Waseda University, Faculty of Education and Integrated Arts and Sciences, Research Associate (40434261)
|
Project Period (FY) |
2006 – 2007
|
Keywords | newt / courtship behavior / prolactin / arginine vasotocin / central action of proteinacious hormones / hormone receptors |
Research Abstract |
In the newt, Cynops pyrrhogaster,internal fertilization takes place in spite of the absence of copulatory organs. In order to transfer the spermatophore into the cloaca of the female, the male performs an unique courtship behavior. Our previous study revealed that besides androgen, prolactin(PRL) and arginine vasotocin(AVT) are involved in the expression of the courtship behavior and that both PRL and AVT act centrally to elicit the behavior .Immunohistochemical study using antibody against PRL receptor demonstrated that both the choroidal plexus and AVT containing neurons possess PRL receptors. Moreover pharmacological study using inhibitors of AVT receptors revealed that the action of AVT in terms of eliciting the behavior is mediated through Vla receptor, its distribution in the diencephalon being confined to the preoptic area, suprachiasmatic nucleus and ventral hypothalamus. This raised the possibility that PRL incorporated into the brain through the choroidal plexus acts on the AVT neurons and AVT mediates the action of PRL. To prove this hypothesis, experiments were conducted using androgen-primed male newts. Firstly it was confirmed that intracerebroventricular injection of antibody against PRL or antibody against PRL receptor blocked the expression of courtship behavior and that administration of AVT restored the expression of courtship behavior. On the other hand, the suppression of the behavior induced by the intracerebroventricular administration of an inhibitor of Vla receptor was never nullified by PRL supplementation. These results indicate that PRL primarily acts on the AVT neurons and AVT mediates the action of PRL to elicit the courtship behavior.
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[Journal Article] Bisphenol A acts differently from thyroid hormone in suppressing thyrotropin release from the bullfrog pituitary2008
Author(s)
Kaneko, M., Okada, R., Yamamoto, K., Nakamura, M., Mosconi, G., Polzonetti-Magni, AM., Kikuyama, S.
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Journal Title
General and Comparative Endocrinology 155
Pages: 574-578
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Effect of endocrine disrupting compounds on the reproductive axis in amphibians2007
Author(s)
Polzonetti-Magni, AM., Palermo, F., Mosconi, G., Guastalla, A., Franzoni, MF, Kikuyama, S.
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Journal Title
In "The Endocrine Disruptors"(M.Mariano and DG.Mita Eds), Trans World Research Networks, Kerala, India
Pages: 13-28
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
[Journal Article] Evidence for processing enzymes in the abdominal gland of the newt, Cynops pyrrhogaster.That generate sodefrinfrom its biosynthetic precursor2007
Author(s)
Nakada, T., Ishizuka, Y., Iwata, T., Toyoda, F., Kato, T., Conlon, JM., Kikuyama, S.
-
Journal Title
Zoological Science 124
Pages: 521-524
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
[Journal Article] Localization,characterization and function of pituitary adenylate cyclase-activating polypeptide during brain development2007
Author(s)
Watanabe, J., Nakamachi, T., Matsuno, R., Hayashi, D., Nakamura, M., Kikuyama, S., Nakajo, S., Shioda, S.
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Journal Title
Peptides 28
Pages: 1713-1719
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] VIP and PACAP stimulate TSH release from the bullfrog pituitary2007
Author(s)
Okada, R., Yamamoto, K., Ito, Y., Mochida, H., Tonon, M-C., Fournier, A., Leprince, J., Vaudry H., Kikuyama, S.
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Journal Title
Peptides 28
Pages: 1784-1789
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Molecular cloning of three types of arginine vasotocin receptor in the newt,Cynops pyrrhogaster2007
Author(s)
Hasunuma, I., Sakai, T., Nakada, T., Toyoda, F., Namiki, H., Kikuyama, S.
-
Journal Title
General and Comparative Endocrinology 151
Pages: 252-258
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
[Journal Article] Isolation,characterization and bioactivity of a region-specific pheromone,[Val8]sodefrin from the newt Cynops pyrrhogaster2007
Author(s)
Nakada, T., Toyoda, F., Iwata, T., Yamamoto, K., Conlon, J.M., Kato, T., Kikuyama, S.
-
Journal Title
Peptides 28
Pages: 774-780
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
-
[Journal Article] Effect of endocrine disrupting compounds on the reproductive axis in amphibians2007
Author(s)
Polzonetti- Magni, AM.,Palermo, F.,Mosconi, G., Guastalla, A.,Franzoni,MF,Kikuyama,S.
-
Journal Title
In The Endocrine Disruptors (M. Mariano and DG. Mita Eds), Trans World Research Networks, Kerala, India.
Pages: 13-28
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Evidence for processing enzymes in the abdominal gland of the newt, Cynops pyrrhogaster. That generate sodefrinfrom its biosynthetic precursor.2007
Author(s)
Nakada, T., Ishizuka, Y., Iwata, T., Toyoda, F., Kato, T., Conlon, JM., Kikuyama, S.
-
Journal Title
Zoological Science 124
Pages: 521-524
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Localization, characterization and function of pituitary adenylate cyclase-activating polypeptide during brain development.2007
Author(s)
Watanabe, J., Nakamachi, T., Matsuno, R., Hayashi, D., Nakamura, M., Kikuyama, S., Nakajo, S., Shioda, S.
-
Journal Title
Peptides 28
Pages: 1713-1719
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Molecular cloning of three types of arginine vasotocin receptor in the newt, Cynops pyrrhogaster2007
Author(s)
Hasunuma, I., Sakai, T., Nakada, T., Toyoda, F., Namiki, H., Kikuyama, S
-
Journal Title
General and Comparative Endocrinology 151
Pages: 252-258
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Isolation, characterization and bioactivity of a region-specific pheromone, [Val8]sodefrin from the newt Cynops pyrrhogaster2007
Author(s)
Nakada, T., Toyoda, F., Iwata, T., Yamamoto, K., Conlon, J. M., Kato, T., Kikuyama, S.
-
Journal Title
Peptides 28
Pages: 774-780
Description
「研究成果報告書概要(欧文)」より
-
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[Journal Article] Effects of pituitary adenylate cyclase-activating polypeptide,vasoactive intestinal polypeptide,and somatostatin on the release of thyrotropin from the bullfrog pituitary2006
Author(s)
Okada, R., Yamamoto, K., Chartrel, N., Lepprince, J., Fournier, A., Vaudry, H. and Kikuyama, S.
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Journal Title
Annals of the New York Academy of Sciences 1070
Pages: 474-480
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
[Journal Article] Identification of immunoreactive plasma and stomach ghrelin,and expression of stomach ghrelin mRNA in the bullfrog,Rana catesbeiana2006
Author(s)
Kaiya, H., Sakata, I., Yamamoto, K., Koda, A., Sakai, T., Kangawa, K., Kikuyama, S.
-
Journal Title
General and Comparative Endocrinology 148
Pages: 236-244
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
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[Journal Article] Pituitary adenylate cyclase-activating polypeptide-induced differentiation of embryonic neural stem cells into astrocytes is mediated via the beta isoform of protein kinase C2006
Author(s)
Watanebe, J., Ohba, M., Ohno, F., Kikuyams, S., Nakamura, M., Nakaya, K., Arimura, A., Shioda, S., Nakajo, S.
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Journal Title
Journal of neuroscience research 84
Pages: 1645-1655
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Involvement of beta-isoform of PKC in PACAP-induceddifferentiation ofneural stem cells into astrocytes2006
Author(s)
Nakajo S., Watanabe, J., Ohba, M., Ohno, F., Kikuyama, S., Nakaya, K., Shioda, S.
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Journal Title
In "New Frontiers in Regenerative Medicine"Springer-Verlag, Tokyo
Pages: 121-134
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
[Journal Article] Molecular cloning and functional characterization of a prolactin-releasing peptide homolog from Xenopus laevis2006
Author(s)
Sakamoto, T., Oda, A., Yamamoto, K., Kaneko, M., Kikuyama, S., Nishikawa, A., Takahashi, A., Kawauchi, H., Tsutsui, K., Fujimoto, M.
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Journal Title
Peptides 27
Pages: 3347-3351
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
-
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[Journal Article] Structures and diverse functions of frog growth hormone-releasing peptide(fGRP) and its related peptides(fGRP-RPs):a review2006
Author(s)
Ukena, K., Koda, A., Yamamoto, K., Iwakoshi-Ukena, E., Minakata, H., Kikuyama, S., Tsutsui, K.
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Journal Title
Journal of Experimental Zoology A Comparative Experimental Biology 305
Pages: 815-821
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
[Journal Article] Involvement of protein kinase C in the PACAP-induced differentiation of neural stem cells into astrocytes2006
Author(s)
Watanebe, J., Ohno, F., Shioda, S., Kikuyama, S., Nakaya, K., Nakajo, S.
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Journal Title
Annals of the New York Academy of Sciences 1070
Pages: 597-601
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
-
[Journal Article] Pituitary adenylate cyclase-activating polypeptide-induced differentiation of embryonic neural stem cells into astrocytes is mediated via the beta isoform of protein kinase C2006
Author(s)
Watanebe, J., Ohba, M., Ohno, F., Kikuyama, S., Nakamura, M., Nakaya, K., Arimura, A., Shioda, S., Nakajo, S.
-
Journal Title
Journal of Neuroscience Research 84
Pages: 1645-1655
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Involvement of beta-isoform of PKC in PACAP-induceddifferentiation ofneural stem cells into astrocytes2006
Author(s)
Nakajo S.,Watanabe, J.,Ohba,M., Ohno,F., Kikuyama, S., Nakaya, K., Shioda,S.
-
Journal Title
In New Frontiers in Regenerative Medicine Springer-Verlag, Tokyo.
Pages: 121-134
Description
「研究成果報告書概要(欧文)」より
-
-
[Journal Article] Structures and diverse functions of frog growth hormone-releasing peptide (fGRP) and its related peptides (fGRP-RPs): a review.2006
Author(s)
Ukena, K., Koda, A., Yamamoto, K., Iwakoshi-Ukena, E., Minakata, H., Kikuyama, S., Tsutsui, K.
-
Journal Title
Journal of Experimental Zoology A Comparative Experimental Biology 305
Pages: 815-821
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Involvement of protein kinase C in the PACAP-induced differentiation of neural stem cells into astrocytes2006
Author(s)
Watanebe, J., Ohno, F., Shioda, S., Kikuyama, S., Nakaya, K., Nakajo, S.
-
Journal Title
Annals of New York Academy of Sciences 1070
Pages: 597-601
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Effects of pituitary adenylate cyclase-activating polypeptide, vasoactive intestinal polypeptide, and somatostatin on the release of thyrotropin from the bullfrog pituitary2006
Author(s)
Okada, R., Yamamoto, K., Chartrel, N., Lepprince, J., Fournier, A., Vaudry, H., Kikuyama, S.
-
Journal Title
Annals of New York Academy of Sciences 1070
Pages: 474-480
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Identification of immunoreactive plasma and stomach ghrelin, and expression of stomach ghrelin mRNA in the bullfrog, Rana catesbeiana2006
Author(s)
Kaiya, H., Sakata, I., Yamamoto, K., Koda, A., Sakai, T., Kangawa, K., Kikuyama, S.
-
Journal Title
General and Comparative Endocrinology 148
Pages: 236-244
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
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[Presentation] Effect of estrogen and prolactin on the perception of sodefrin in femele newts, Cynops pyrrhogaster2007
Author(s)
Nakada, T., Iwata, T., Yamamoto, K., Toyoda, F., Tsutsui, K., Kikuyama, S.
Organizer
The 32nd Congress and Symposium of Japan Society of Comparative Endocrinology
Place of Presentation
Nikko
Year and Date
20071012-13
Description
「研究成果報告書概要(欧文)」より
-
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[Presentation] Changes of corticotropin-releasing factor expression in the brain of the bullfrog, Rana catesbeiana during metamorphosis2007
Author(s)
Hashimoto, S., Okada, R., Mochida, H., Kikuyama, S., Uchiyama, M., Matsuda, K.
Organizer
The 32nd Congress and Symposium of Japan Society of Comparative Endocrinology
Place of Presentation
Nikko
Year and Date
20071012-13
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] Yamamoto, K., Kikuyama, S., Kobayashi, T., Machida, T. Identification of cDNAs encoding thyrotropin-releasing hormone receptor from the bullfrog2007
Author(s)
Minagawa, A., Hasunuma, I., Nakano, M., Okada, R.
Organizer
The 32nd Congress and Symposium of Japan Society of Comparative Endocrinology
Place of Presentation
Nikko
Year and Date
20071012-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Involvement of D2 dopamine receptor subtype in inhibition of prolactin release from the bullfrog pituitary gland2007
Author(s)
Nakano, M., Hasunuma, I., Okada, R., Yamamoto, K., Kikuyama, S., Kobayashi, T. Machida, T.
Organizer
The 32nd Congress and Symposium of Japan Society of Comparative Endocrinology
Place of Presentation
Nikko
Year and Date
20071012-13
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
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[Presentation] Expression of vomeronasal receptor genes in Cynops pyrrhogaster2007
Author(s)
Nakada, T., Ito, A., Yamagishi, K., Toyoda, F., Osada, T., Ichikawa, M., Tsutsui, K., Kikuyama S.
Organizer
The 78th Annual Meeting of the Zoological Society of Japan
Place of Presentation
Hirosaki
Year and Date
20070920-22
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Involvement of 7alpha-hydroxypregnenolone in the induction of courtship behavior in the male red-bellied newt2007
Author(s)
Toyoda, F., Haraguchi, S., Matsunaga, M., Nakada, T., Tsutsui, K., Kikuyama, S.
Organizer
The 78th Annual Meeting of the Zoological Society of Japan
Place of Presentation
Hirosaki
Year and Date
20070920-22
Description
「研究成果報告書概要(欧文)」より
-
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[Presentation] Melatonin stimulate the release of GH and PRL by increasing the expression of frog GH-releasing peptide(fGRP) and its related peptide-22007
Author(s)
Chowdhury, V.S., Yamamoto, K., Saeki, I., Hasunuma, I., Kikuyama, S., Tsutsui, K.
Organizer
The 78th Annual Meeting of the Zoological Society of Japan
Place of Presentation
Hirosaki
Year and Date
20070920-22
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
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[Presentation] Structures, diverse actions and functional significance of (fGRP) and its related peptides (fGRP-RPs)2007
Author(s)
Tsutsui, K., Koda, A., Sawada, K., Ukena, K., Chowdry, VS., Saeki, I., Yamamoto, K., Hasunuma, I., Klkuyama, S
Organizer
International Symposium on Amphibian and Reptile Endocrinology and Neurobiology
Place of Presentation
Berkeley
Year and Date
20070326-28
Description
「研究成果報告書概要(和文)」より
-
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[Presentation] Structures, diverse actions and functional significance of(fGRP) and its related peptides(fGRP-RPs)2007
Author(s)
Tsutsui, K., Koda, A.Sawada, K., Ukena, K.Chowdry, VS., Saiki,I., Yamamoto, K., Hasunuma, I., Klkuyama, S.
Organizer
International Symposium on Amphibian and Reptile Endocrinology and Neurobiology
Place of Presentation
Berkeley
Year and Date
20070326-28
Description
「研究成果報告書概要(欧文)」より
-
-
-
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[Presentation] Mechanisms of TRH-induced PRL release from the bullfrog pituitary gland2006
Author(s)
Minagawa, A., Hasunuma, I., Yamamoto, K., Kikuyama, S., Kobayashi, T., Machida, T.
Organizer
The 31st Congress and Symposium of Japan Society of Comparative Endocrinology
Place of Presentation
Sapporo
Year and Date
20061103-04
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
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[Presentation] Female attracting activity of steroidal substances released from the abdominal gland of the male newt2006
Author(s)
Toyoda, F., Haraguchi, S., Matsunaga, M., Tsutsui, K., Nakada, T., Nakamura, M., Yamamoto, K., Kikuyama, S.
Organizer
The 77th Annual Meeting of the Zoological Society of Japan
Place of Presentation
Matsue
Year and Date
20060921-24
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] Evidence for processing enzymes in the abdominal gland of the newt, Cynops pyrrhogaster. That generate sodefrin from its biosynthetic precursor.2006
Author(s)
Nakada, T., Toyoda, F., Iwata, T., Ishizuka, Y., Kato, T., Kikuyama, S.
Organizer
The 77th Annual Meeting of the Zoological Society of Japan
Place of Presentation
Matsue
Year and Date
20060921-24
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] Melatonin elicits the expression of frog growth hormone releasing peptide in the frog brain2006
Author(s)
Chowdhury, VS., Ukena, K., Hasunuma, I., Yamamoto, K., Kikuyama, S., Tsutsui, K.
Organizer
The 77th Anniial Meeting of the Zoological Society of Japan
Place of Presentation
Matsue
Year and Date
20060921-24
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Changes in the expression of corticotropin releasing factor in the brain of metamorphosing bullfrog larvae2006
Author(s)
Hashimoto, S., Okada, R., Mochida, S., Uchiyama, M., Kikuyama, S., Matsuda, K.
Organizer
The 77th Annual Meeting of the Zoological Society of Japan
Place of Presentation
Matsue
Year and Date
20060921-24
Description
「研究成果報告書概要(欧文)」より
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[Presentation] The release of TSH induced by corticotropin releasing factor from the bullfrog pituitary is mediated through the type 2 receptor2006
Author(s)
Okada, R., Kobayashi, T., Miller, M., Yamamoto, K., Denver, R., Kikuyama, S.
Organizer
The 77th Annual Meeting of the Zoological Society of Japan
Place of Presentation
Matsue
Year and Date
20060921-24
Description
「研究成果報告書概要(欧文)」より
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[Presentation] A possible synergistic action of sodefrin and steroidal substances to attract female newts2006
Author(s)
Kikuyama, s., Toyoda, F., Haraguchi, S., Matsunaga, M., Yamamoto, K., Tsutsui, K.
Organizer
3rd Conference of European Comparative Endocrinologists
Place of Presentation
Manchester
Year and Date
20060829-0902
Description
「研究成果報告書概要(和文)」より
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[Presentation] Localization of two types of Arginine vasotocin receptor in the newt brain2006
Author(s)
Hasunuma, I., Nakada, T., Sakai, T., Toyoda, F., Yamamoto, K., Kikuyama, S.
Organizer
3rd Conference of European Comparative Endocrinologists
Place of Presentation
Manchester
Year and Date
20060829-0902
Description
「研究成果報告書概要(和文)」より
-
[Presentation] Stimulation of thyrotropin release from the bullfrog pituitary by PACAP and VIP2006
Author(s)
Okada, R., Yamamoto, K., Chartrel, N., Fournier, A, Naudry, H., Kikuyama, S.
Organizer
3rd Conference of European Comparative Endocrinologists
Place of Presentation
Manchester
Year and Date
20060829-0902
Description
「研究成果報告書概要(和文)」より
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[Presentation] A possible synergistic action of, sodefrin and steroidal substances to attract female newts.2006
Author(s)
Kikuyama, s., Toyoda, F., Haraguchi, S., Matsunaga, M., Yamamoto,K., Tsutsui, K
Organizer
23rd Conference of European Comparative Endocrinologists.
Place of Presentation
Manchester
Year and Date
20060829-0902
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Localization of two types of Arginine vasotocin receptor in the newt brain.2006
Author(s)
Hasunuma, I., Nakada, T.,Sakai, T.,Toyoda, F.,Yamamoto, K, Kikuyama, S.
Organizer
23rd Conference of European Comparative Endocrinologists.
Place of Presentation
Manchester
Year and Date
20060829-0902
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] Stimulation of thyrotropin release from the bullfrog pituitary by PACAP and VIP2006
Author(s)
Okada, R.,Yamamoto, K., Chartrel, N.,Fournier, A, Vaudry, H., Kikuyama, S.
Organizer
23rd Conference of European Comparative Endocrinologists.
Place of Presentation
Manchester
Year and Date
20060829-0902
Description
「研究成果報告書概要(欧文)」より
-
-
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[Presentation] Signal transduction pathways for sodefrin in vomeronasal cells of the female newt,Cynopspyrrhogaster2006
Author(s)
Nakada, T., Iwata, T., Kaneko, M., Yada, T., Shioda, S., Kikuyama, S
Organizer
Sixth International Congress of Neuroendocrinology
Place of Presentation
Pittsburgh
Year and Date
20060619-22
Description
「研究成果報告書概要(和文)」より
-
-
[Presentation] Thyroid hormone and bisphenol A act differently on the pituitary to suppress the release of thyrotropin2006
Author(s)
Kaneko, M., Okada, R., Nakada, T., Yamamoto, K., Nakamura, M., Kikuyama, S
Organizer
Sixth International Congress of Neuroendocrinology
Place of Presentation
Pittsburgh
Year and Date
20060619-22
Description
「研究成果報告書概要(和文)」より
-
-
[Presentation] Signal transduction pathways for sodefrin in vomeronasal cells of the female newt, Cynops pyrrhogaster2006
Author(s)
Nakada, T, Iwata, T., Kaneko, M., Yada, T., Shioda, S., Kikuyama, S.
Organizer
Sixth International Congress of Neuroendocrinology
Place of Presentation
Pittsburgh
Year and Date
20060619-22
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] Thyroid hormone and bisphenol A act differently on the pituitary to suppress the release of thyrotropin.2006
Author(s)
Kaneko, M., Okada, R., Nakada, T., Yamamoto, K., Nakamura, M., Kikuyama, S.
Organizer
Sixth International Congress of Neuroendocrinology
Place of Presentation
Pittsburgh
Year and Date
20060619-22
Description
「研究成果報告書概要(欧文)」より