Central action of proteinacious hormones

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 18570063
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphology/Structure
• Research Institution: Waseda University
• Principal Investigator: KIKUYAMA Sakae Waseda University, Faculty of Education and Integrated Arts and Sciences, Professor Emeritus (20063638)
• Co-Investigator(Kenkyū-buntansha): TOYODA Fumiyo Nara Medical University, Faculty of Medicine, Lecturer (10244708) ; HASUNUMA Itaru Waseda University, Faculty of Education and Integrated Arts and Sciences, Research Associate (40434261)
• Project Period (FY): 2006 – 2007
• Keywords: newt / courtship behavior / prolactin / arginine vasotocin / central action of proteinacious hormones / hormone receptors

Research Abstract

In the newt, Cynops pyrrhogaster,internal fertilization takes place in spite of the absence of copulatory organs. In order to transfer the spermatophore into the cloaca of the female, the male performs an unique courtship behavior. Our previous study revealed that besides androgen, prolactin(PRL) and arginine vasotocin(AVT) are involved in the expression of the courtship behavior and that both PRL and AVT act centrally to elicit the behavior .Immunohistochemical study using antibody against PRL receptor demonstrated that both the choroidal plexus and AVT containing neurons possess PRL receptors. Moreover pharmacological study using inhibitors of AVT receptors revealed that the action of AVT in terms of eliciting the behavior is mediated through Vla receptor, its distribution in the diencephalon being confined to the preoptic area, suprachiasmatic nucleus and ventral hypothalamus. This raised the possibility that PRL incorporated into the brain through the choroidal plexus acts on the AVT neurons and AVT mediates the action of PRL. To prove this hypothesis, experiments were conducted using androgen-primed male newts. Firstly it was confirmed that intracerebroventricular injection of antibody against PRL or antibody against PRL receptor blocked the expression of courtship behavior and that administration of AVT restored the expression of courtship behavior. On the other hand, the suppression of the behavior induced by the intracerebroventricular administration of an inhibitor of Vla receptor was never nullified by PRL supplementation. These results indicate that PRL primarily acts on the AVT neurons and AVT mediates the action of PRL to elicit the courtship behavior.

Research Products

• [Journal Article] Bisphenol A acts differently from thyroid hormone in suppressing thyrotropin release from the bullfrog pituitary (2008)
  • Author(s): Kaneko, M., Okada, R., Yamamoto, K., Nakamura, M., Mosconi, G., Polzonetti-Magni, AM., Kikuyama, S.
  • Journal Title: General and Comparative Endocrinology 155 Pages: 574-578
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effect of endocrine disrupting compounds on the reproductive axis in amphibians (2007)
  • Author(s): Polzonetti-Magni, AM., Palermo, F., Mosconi, G., Guastalla, A., Franzoni, MF, Kikuyama, S.
  • Journal Title: In "The Endocrine Disruptors"(M.Mariano and DG.Mita Eds), Trans World Research Networks, Kerala, India Pages: 13-28
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Evidence for processing enzymes in the abdominal gland of the newt, Cynops pyrrhogaster.That generate sodefrinfrom its biosynthetic precursor (2007)
  • Author(s): Nakada, T., Ishizuka, Y., Iwata, T., Toyoda, F., Kato, T., Conlon, JM., Kikuyama, S.
  • Journal Title: Zoological Science 124 Pages: 521-524
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Localization,characterization and function of pituitary adenylate cyclase-activating polypeptide during brain development (2007)
  • Author(s): Watanabe, J., Nakamachi, T., Matsuno, R., Hayashi, D., Nakamura, M., Kikuyama, S., Nakajo, S., Shioda, S.
  • Journal Title: Peptides 28 Pages: 1713-1719
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] VIP and PACAP stimulate TSH release from the bullfrog pituitary (2007)
  • Author(s): Okada, R., Yamamoto, K., Ito, Y., Mochida, H., Tonon, M-C., Fournier, A., Leprince, J., Vaudry H., Kikuyama, S.
  • Journal Title: Peptides 28 Pages: 1784-1789
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Molecular cloning of three types of arginine vasotocin receptor in the newt,Cynops pyrrhogaster (2007)
  • Author(s): Hasunuma, I., Sakai, T., Nakada, T., Toyoda, F., Namiki, H., Kikuyama, S.
  • Journal Title: General and Comparative Endocrinology 151 Pages: 252-258
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Isolation,characterization and bioactivity of a region-specific pheromone,[Val8]sodefrin from the newt Cynops pyrrhogaster (2007)
  • Author(s): Nakada, T., Toyoda, F., Iwata, T., Yamamoto, K., Conlon, J.M., Kato, T., Kikuyama, S.
  • Journal Title: Peptides 28 Pages: 774-780
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Control of thyroid stimulating hormone secretion in amphibians (2007)
  • Author(s): Okada, R., Kaneko, M., Yamamoto, K., Kikuyama, S.
  • Journal Title: In "Hormone Biotechnology"(S.K.Maitra Ed.).Daya Publishing House, Delhi Pages: 248-265
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effect of endocrine disrupting compounds on the reproductive axis in amphibians (2007)
  • Author(s): Polzonetti- Magni, AM.,Palermo, F.,Mosconi, G., Guastalla, A.,Franzoni,MF,Kikuyama,S.
  • Journal Title: In The Endocrine Disruptors (M. Mariano and DG. Mita Eds), Trans World Research Networks, Kerala, India. Pages: 13-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Evidence for processing enzymes in the abdominal gland of the newt, Cynops pyrrhogaster. That generate sodefrinfrom its biosynthetic precursor. (2007)
  • Author(s): Nakada, T., Ishizuka, Y., Iwata, T., Toyoda, F., Kato, T., Conlon, JM., Kikuyama, S.
  • Journal Title: Zoological Science 124 Pages: 521-524
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Localization, characterization and function of pituitary adenylate cyclase-activating polypeptide during brain development. (2007)
  • Author(s): Watanabe, J., Nakamachi, T., Matsuno, R., Hayashi, D., Nakamura, M., Kikuyama, S., Nakajo, S., Shioda, S.
  • Journal Title: Peptides 28 Pages: 1713-1719
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular cloning of three types of arginine vasotocin receptor in the newt, Cynops pyrrhogaster (2007)
  • Author(s): Hasunuma, I., Sakai, T., Nakada, T., Toyoda, F., Namiki, H., Kikuyama, S
  • Journal Title: General and Comparative Endocrinology 151 Pages: 252-258
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Isolation, characterization and bioactivity of a region-specific pheromone, [Val8]sodefrin from the newt Cynops pyrrhogaster (2007)
  • Author(s): Nakada, T., Toyoda, F., Iwata, T., Yamamoto, K., Conlon, J. M., Kato, T., Kikuyama, S.
  • Journal Title: Peptides 28 Pages: 774-780
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] (2007) Control of thyroid stimulating hormone secretion in amphibians (2007)
  • Author(s): Okada, R.,Kaneko, M., Yamamoto, K., Kikuyama, S.
  • Journal Title: In "Hormone Biotechnology" (S.K.Maitra Ed.). Daya Publishing House, Delhi. Pages: 248-265
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of pituitary adenylate cyclase-activating polypeptide,vasoactive intestinal polypeptide,and somatostatin on the release of thyrotropin from the bullfrog pituitary (2006)
  • Author(s): Okada, R., Yamamoto, K., Chartrel, N., Lepprince, J., Fournier, A., Vaudry, H. and Kikuyama, S.
  • Journal Title: Annals of the New York Academy of Sciences 1070 Pages: 474-480
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification of immunoreactive plasma and stomach ghrelin,and expression of stomach ghrelin mRNA in the bullfrog,Rana catesbeiana (2006)
  • Author(s): Kaiya, H., Sakata, I., Yamamoto, K., Koda, A., Sakai, T., Kangawa, K., Kikuyama, S.
  • Journal Title: General and Comparative Endocrinology 148 Pages: 236-244
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cloning and distribution of the bullfrog type 1 and type 2 corticotropin-releasing factor receptors (2006)
  • Author(s): Ito, Y., Okada, R., Takahashi, N., Kikuyama, S.
  • Journal Title: General and Comparative Endocrinology 146 Pages: 291-295
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of the corticotropin-releasing factor(CRF) type 2 receptor in CRF-induced thyrotropin release by the amphibian pituitary gland (2006)
  • Author(s): Okada, R., Miller M.F., Yamamoto, K., Groef B.D., Denver, R.J., Kikuyama, S.
  • Journal Title: General and Comparative Endocrinology 150 Pages: 437-444
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide-induced differentiation of embryonic neural stem cells into astrocytes is mediated via the beta isoform of protein kinase C (2006)
  • Author(s): Watanebe, J., Ohba, M., Ohno, F., Kikuyams, S., Nakamura, M., Nakaya, K., Arimura, A., Shioda, S., Nakajo, S.
  • Journal Title: Journal of neuroscience research 84 Pages: 1645-1655
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of beta-isoform of PKC in PACAP-induceddifferentiation ofneural stem cells into astrocytes (2006)
  • Author(s): Nakajo S., Watanabe, J., Ohba, M., Ohno, F., Kikuyama, S., Nakaya, K., Shioda, S.
  • Journal Title: In "New Frontiers in Regenerative Medicine"Springer-Verlag, Tokyo Pages: 121-134
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Molecular cloning and functional characterization of a prolactin-releasing peptide homolog from Xenopus laevis (2006)
  • Author(s): Sakamoto, T., Oda, A., Yamamoto, K., Kaneko, M., Kikuyama, S., Nishikawa, A., Takahashi, A., Kawauchi, H., Tsutsui, K., Fujimoto, M.
  • Journal Title: Peptides 27 Pages: 3347-3351
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effect of bisphenol A on thyroid hormone-dependent up-regulation of thyroid hormone receptor alpha and beta and down-regulation of retinoid X receptor gamma in Xenopus tail culture (2006)
  • Author(s): Iwamuro, S., Yamada, M., Kato, M., Kikuyama, S.
  • Journal Title: Life Sciences 79 Pages: 2165-2171
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Sodefrin and Related Pheromones (2006)
  • Author(s): Kikuyama, S.
  • Journal Title: In "The Handbook of Biologically Active Peptides"(A.J.Kastin Ed.).Academic Press, New York Pages: 321-326
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Structures and diverse functions of frog growth hormone-releasing peptide(fGRP) and its related peptides(fGRP-RPs):a review (2006)
  • Author(s): Ukena, K., Koda, A., Yamamoto, K., Iwakoshi-Ukena, E., Minakata, H., Kikuyama, S., Tsutsui, K.
  • Journal Title: Journal of Experimental Zoology A Comparative Experimental Biology 305 Pages: 815-821
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of protein kinase C in the PACAP-induced differentiation of neural stem cells into astrocytes (2006)
  • Author(s): Watanebe, J., Ohno, F., Shioda, S., Kikuyama, S., Nakaya, K., Nakajo, S.
  • Journal Title: Annals of the New York Academy of Sciences 1070 Pages: 597-601
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of the corticotropin-releasing factor(CRF) type 2 receptor in CRF-induced thyrotropin release by the amphibian pituitary gland (2006)
  • Author(s): Okada, R., Miller M. F., Yamamoto, K., Groef B. D., Denver, R. J., Kikuyama, S.
  • Journal Title: General and Comparative Endocrinology 150 Pages: 437-444
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide-induced differentiation of embryonic neural stem cells into astrocytes is mediated via the beta isoform of protein kinase C (2006)
  • Author(s): Watanebe, J., Ohba, M., Ohno, F., Kikuyama, S., Nakamura, M., Nakaya, K., Arimura, A., Shioda, S., Nakajo, S.
  • Journal Title: Journal of Neuroscience Research 84 Pages: 1645-1655
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of beta-isoform of PKC in PACAP-induceddifferentiation ofneural stem cells into astrocytes (2006)
  • Author(s): Nakajo S.,Watanabe, J.,Ohba,M., Ohno,F., Kikuyama, S., Nakaya, K., Shioda,S.
  • Journal Title: In New Frontiers in Regenerative Medicine Springer-Verlag, Tokyo. Pages: 121-134
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sodefrin and Related Pheromones (2006)
  • Author(s): Kikuyama, S.
  • Journal Title: In The Handbook of Biologically Active Peptides (A. J. Kastin Ed.). Academic Press, New York Pages: 321-326
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structures and diverse functions of frog growth hormone-releasing peptide (fGRP) and its related peptides (fGRP-RPs): a review. (2006)
  • Author(s): Ukena, K., Koda, A., Yamamoto, K., Iwakoshi-Ukena, E., Minakata, H., Kikuyama, S., Tsutsui, K.
  • Journal Title: Journal of Experimental Zoology A Comparative Experimental Biology 305 Pages: 815-821
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of protein kinase C in the PACAP-induced differentiation of neural stem cells into astrocytes (2006)
  • Author(s): Watanebe, J., Ohno, F., Shioda, S., Kikuyama, S., Nakaya, K., Nakajo, S.
  • Journal Title: Annals of New York Academy of Sciences 1070 Pages: 597-601
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of pituitary adenylate cyclase-activating polypeptide, vasoactive intestinal polypeptide, and somatostatin on the release of thyrotropin from the bullfrog pituitary (2006)
  • Author(s): Okada, R., Yamamoto, K., Chartrel, N., Lepprince, J., Fournier, A., Vaudry, H., Kikuyama, S.
  • Journal Title: Annals of New York Academy of Sciences 1070 Pages: 474-480
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of immunoreactive plasma and stomach ghrelin, and expression of stomach ghrelin mRNA in the bullfrog, Rana catesbeiana (2006)
  • Author(s): Kaiya, H., Sakata, I., Yamamoto, K., Koda, A., Sakai, T., Kangawa, K., Kikuyama, S.
  • Journal Title: General and Comparative Endocrinology 148 Pages: 236-244
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cloning and distribution of the bullfrog type 1 and type 2 corticotropin-releasing factor receptors (2006)
  • Author(s): Ito, Y., Okada, R., Takahashi, N. Kikuyama, S.
  • Journal Title: General and Comparative Endocrinology 146 Pages: 291-295
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ソデフリン受容のホルモン調節 (2007)
  • Author(s): 中田 友明、岩田 武男、山本 和俊、豊田 ふみよ、筒井 和義、菊山 榮
  • Organizer: 第32回日本比較内分泌学会大会およびシンポジウム
  • Place of Presentation: 日光
  • Year and Date: 20071012-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ウシガエル下垂体中葉細胞に発現するアクアポリン(AQP-h3BL)タンパク質 (2007)
  • Author(s): 小宮山 雄大、鈴木 雅一、菊山 榮、田中 滋康
  • Organizer: 第32回日本比較内分泌学会大会およびシンポジウム
  • Place of Presentation: 日光
  • Year and Date: 20071012-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 変態期のウシガエルにおける脳内コルチコトロピン放出因子(CRF)発現の変化 (2007)
  • Author(s): 橋本 宗佑、岡田 令子、持田 弘、菊山 榮、内山 実、松田 恒平
  • Organizer: 第32回日本比較内分泌学会大会およびシンポジウム
  • Place of Presentation: 日光
  • Year and Date: 20071012-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ウシガエル甲状腺刺激ホルモン放出ホルモン受容体の構造と発現解析 (2007)
  • Author(s): 皆川 温子、蓮沼 至、中野 真樹、岡田 令子、山本 和俊、菊山 榮、小林 哲也、町田 武生
  • Organizer: 第32回日本比較内分泌学会大会およびシンポジウム
  • Place of Presentation: 日光
  • Year and Date: 20071012-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ドーパミン(DA)によるウシガエルプロラクチン(PRL)分泌調節機構の解析 (2007)
  • Author(s): 中野 真樹、運沼 至、岡田 令子、山本 和俊、菊山 榮、小林 哲也、町田 武生
  • Organizer: 第32回日本比較内分泌学会大会およびシンポジウム
  • Place of Presentation: 日光
  • Year and Date: 20071012-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] イモリアルギニンバソトシンV3/V1bタイプ受容体の脳内分布 (2007)
  • Author(s): 蓮沼 至、山本 和俊、豊田 ふみよ、並木 秀男、菊山 榮
  • Organizer: 第32回日本比較内分泌学会大会およびシンポジウム
  • Place of Presentation: 日光
  • Year and Date: 20071012-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Effect of estrogen and prolactin on the perception of sodefrin in femele newts, Cynops pyrrhogaster (2007)
  • Author(s): Nakada, T., Iwata, T., Yamamoto, K., Toyoda, F., Tsutsui, K., Kikuyama, S.
  • Organizer: The 32nd Congress and Symposium of Japan Society of Comparative Endocrinology
  • Place of Presentation: Nikko
  • Year and Date: 20071012-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Characterization of an aquaporin, AQP-H3BL, expressed in melanotrophs in the bullfrog pars intermedia (2007)
  • Author(s): Komiyama, Y., Suzuki, M., Kikuyama, S., Tanaka, S.
  • Organizer: The 32nd Congress and Symposium of Japan Society of Comparative Endocrinology
  • Place of Presentation: Nikko
  • Year and Date: 20071012-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Changes of corticotropin-releasing factor expression in the brain of the bullfrog, Rana catesbeiana during metamorphosis (2007)
  • Author(s): Hashimoto, S., Okada, R., Mochida, H., Kikuyama, S., Uchiyama, M., Matsuda, K.
  • Organizer: The 32nd Congress and Symposium of Japan Society of Comparative Endocrinology
  • Place of Presentation: Nikko
  • Year and Date: 20071012-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Yamamoto, K., Kikuyama, S., Kobayashi, T., Machida, T. Identification of cDNAs encoding thyrotropin-releasing hormone receptor from the bullfrog (2007)
  • Author(s): Minagawa, A., Hasunuma, I., Nakano, M., Okada, R.
  • Organizer: The 32nd Congress and Symposium of Japan Society of Comparative Endocrinology
  • Place of Presentation: Nikko
  • Year and Date: 20071012-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Involvement of D2 dopamine receptor subtype in inhibition of prolactin release from the bullfrog pituitary gland (2007)
  • Author(s): Nakano, M., Hasunuma, I., Okada, R., Yamamoto, K., Kikuyama, S., Kobayashi, T. Machida, T.
  • Organizer: The 32nd Congress and Symposium of Japan Society of Comparative Endocrinology
  • Place of Presentation: Nikko
  • Year and Date: 20071012-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] イモリの側鼻腔に発現する鋤鼻受容体とGタンパク質 (2007)
  • Author(s): 中田 友明、伊藤 敦子、山岸 公子 豊田 ふみよ、長田 俊哉、市川 真澄、筒井 和義、菊山 榮
  • Organizer: 日本動物学会第78回大会
  • Place of Presentation: 弘前
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ニューロステロイド7α-ヒドロキシプレグネノロンは雄イモリ求愛行動発現に関与する (2007)
  • Author(s): 豊田 ふみよ、原口 省吾、松永 昌宏、中田 友明、筒井 和義、菊山 榮
  • Organizer: 日本動物学会第78回大会
  • Place of Presentation: 弘前
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] イモリのアルギニンバソトシンV3/V1bタイプ受容体の発現解析 (2007)
  • Author(s): 蓮沼 至、山本 和俊、豊田 ふみよ、並木 秀男、菊山 榮
  • Organizer: 日本動物学会第78回大会
  • Place of Presentation: 弘前
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] メラトニンはfGRPとfGRP-RP2の発現を高めることで下垂体からのGHとPRLの放出を促す (2007)
  • Author(s): チョードリ ビシュワジット、山本 和俊、佐伯 和泉、蓮沼 至、菊山 榮、筒井 和義
  • Organizer: 日本動物学会第78回大会
  • Place of Presentation: 弘前
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 下垂体レヴェルにおけるビスフェノールA(BPA)によるホルモン放出攪乱 (2007)
  • Author(s): 岡田 令子、山本 和俊、金子 美代子、中村 正久、菊山 榮
  • Organizer: 日本動物学会第78回大会
  • Place of Presentation: 弘前
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 哺乳類アクアポリン(AQP)3に相同なツメガエルAQP-x3BLの免疫組織発現部位 (2007)
  • Author(s): 持田 弘、中倉 敬、鈴木 雅一、菊山 榮
  • Organizer: 日本動物学会第78回大会
  • Place of Presentation: 弘前
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 両生類下垂体研究にまつわるささやかなセレンディピティー (2007)
  • Author(s): 菊山 榮
  • Organizer: 日本動物学会第78回大会
  • Place of Presentation: 弘前
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 甦るステロイド:イモリ肛門腺でつくられる第二のフェロモン (2007)
  • Author(s): 豊田 ふみよ
  • Organizer: 日本動物学会第78回大会
  • Place of Presentation: 弘前
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression of vomeronasal receptor genes in Cynops pyrrhogaster (2007)
  • Author(s): Nakada, T., Ito, A., Yamagishi, K., Toyoda, F., Osada, T., Ichikawa, M., Tsutsui, K., Kikuyama S.
  • Organizer: The 78th Annual Meeting of the Zoological Society of Japan
  • Place of Presentation: Hirosaki
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Involvement of 7alpha-hydroxypregnenolone in the induction of courtship behavior in the male red-bellied newt (2007)
  • Author(s): Toyoda, F., Haraguchi, S., Matsunaga, M., Nakada, T., Tsutsui, K., Kikuyama, S.
  • Organizer: The 78th Annual Meeting of the Zoological Society of Japan
  • Place of Presentation: Hirosaki
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Expression of arginine vasotosin V3/V1b-type receptor in the newt brain and pituitary (2007)
  • Author(s): Hasunuma, I., Yamamoto, K., Toyoda, F., Namiki, H., Kikuyama, S.
  • Organizer: The 78th Annual Meeting of the Zoological Society of Japan
  • Place of Presentation: Hirosaki
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Melatonin stimulate the release of GH and PRL by increasing the expression of frog GH-releasing peptide(fGRP) and its related peptide-2 (2007)
  • Author(s): Chowdhury, V.S., Yamamoto, K., Saeki, I., Hasunuma, I., Kikuyama, S., Tsutsui, K.
  • Organizer: The 78th Annual Meeting of the Zoological Society of Japan
  • Place of Presentation: Hirosaki
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] In vitro study of the effect of bisphenol A on the release of thyrotropin and prolactin from the bullfrog pituitary (2007)
  • Author(s): Okada, R., Yamamoto, K., Kaneko, M., Nakamura, M., Kikuyama, S.
  • Organizer: The 78th Annual Meeting of the Zoological Society of Japan
  • Place of Presentation: Hirosaki
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Immunolocalization of Xenopus aquaporin(AQP)-x3BL, a mammalian AQP3 homologue (2007)
  • Author(s): Mochida, H., Nakakura, T., Suzuki, M., Kikuyama, S.
  • Organizer: The 78th Annual Meeting of the Zoological Society of Japan
  • Place of Presentation: Hirosaki
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Serendipitous findings during the course of amphibian pituitary research (2007)
  • Author(s): Kikuyama, S.
  • Organizer: The 78th Annual Meeting of the Zoological Society of Japan
  • Place of Presentation: Hirosaki
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Steroid as courtship pheromone candidate in the red-bellied newt (2007)
  • Author(s): Toyoda, F.
  • Organizer: The 78th Annual Meeting of the Zoological Society of Japan
  • Place of Presentation: Hirosaki
  • Year and Date: 20070920-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Involvement of steroidal substances in the newt reproductive behavior (2007)
  • Author(s): Kikuyama, S., Tsutsui, K.
  • Organizer: International Symposium on Amphibian and Reptile Endocrinology and Neurobiology
  • Place of Presentation: Berkeley
  • Year and Date: 20070326-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Structures, diverse actions and functional significance of (fGRP) and its related peptides (fGRP-RPs) (2007)
  • Author(s): Tsutsui, K., Koda, A., Sawada, K., Ukena, K., Chowdry, VS., Saeki, I., Yamamoto, K., Hasunuma, I., Klkuyama, S
  • Organizer: International Symposium on Amphibian and Reptile Endocrinology and Neurobiology
  • Place of Presentation: Berkeley
  • Year and Date: 20070326-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regulation by CRF of thyrotropin release from the bullfrog pituitary (2007)
  • Author(s): Okada, R., Kikuyama, S
  • Organizer: International Symposium on Amphibian and Reptile Endocrinology and Neurobiology
  • Place of Presentation: Berkeley
  • Year and Date: 20070326-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Structures, diverse actions and functional significance of(fGRP) and its related peptides(fGRP-RPs) (2007)
  • Author(s): Tsutsui, K., Koda, A.Sawada, K., Ukena, K.Chowdry, VS., Saiki,I., Yamamoto, K., Hasunuma, I., Klkuyama, S.
  • Organizer: International Symposium on Amphibian and Reptile Endocrinology and Neurobiology
  • Place of Presentation: Berkeley
  • Year and Date: 20070326-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ウシガエルプロラクチン受容体新規アイソフォームの解析 (2006)
  • Author(s): 連沼 至、山本 和俊、菊山 榮
  • Organizer: 第31回日本比較内分泌学会大会およびシンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 20061103-04
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ウシガエルPRL分泌のTRHによる調節機構の解析 (2006)
  • Author(s): 皆川 温子、蓮沼 至、山本 和俊、菊山 榮、小林 哲也、町田 武生
  • Organizer: 第31回日本比較内分泌学会大会およびシンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 20061103-04
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression of novel isoform of bullfrog prolactin receptor (2006)
  • Author(s): Hasunuma, I., Yamamoto, K., Kikuyama, S.
  • Organizer: The 31st Congress and Symposium of Japan Society of Comparative Endocrinology
  • Place of Presentation: Sapporo
  • Year and Date: 20061103-04
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mechanisms of TRH-induced PRL release from the bullfrog pituitary gland (2006)
  • Author(s): Minagawa, A., Hasunuma, I., Yamamoto, K., Kikuyama, S., Kobayashi, T., Machida, T.
  • Organizer: The 31st Congress and Symposium of Japan Society of Comparative Endocrinology
  • Place of Presentation: Sapporo
  • Year and Date: 20061103-04
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] イモリ脳内アルギニンバソトシン受容体の発現解析 (2006)
  • Author(s): 蓮沼 至、中田 友明、豊田 ふみよ、山本 和俊、菊山 榮
  • Organizer: 日本動物学会第77回大会
  • Place of Presentation: 松江
  • Year and Date: 20060921-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 雄イモリ腹腺中ステロイドの雌誘引効果 (2006)
  • Author(s): 豊田 ふみよ、原口 省吾、松永 昌宏、筒井 和義、中田 友明、中村 真理子、山本 和俊、菊山 榮
  • Organizer: 日本動物学会第77回大会
  • Place of Presentation: 松江
  • Year and Date: 20060921-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 前駆体からソデフリンを生成するプロセシング酵素の存在とその活性の季節変動 (2006)
  • Author(s): 中田 友明、豊田 ふみよ、岩田 武男、石塚 洋子、加藤 尚志、菊山 榮
  • Organizer: 日本動物学会第77回大会
  • Place of Presentation: 松江
  • Year and Date: 20060921-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] メラトニンはカエルの脳において成長ホルモン放出ペプチド(fGRP)の発現を誘導する (2006)
  • Author(s): チョードリ ビシュワジット、浮穴 和義、蓮沼 至、山本 和俊、菊山 榮、筒井 和義
  • Organizer: 日本動物学会第77回大会
  • Place of Presentation: 松江
  • Year and Date: 20060921-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 変態期ウシガエル脳内コルチコトロピン放出因子の発現変化 (2006)
  • Author(s): 橋本 宗佑、岡田、令子、持田 弘、山本 実、菊山 榮、松田 恒平
  • Organizer: 日本動物学会第77回大会
  • Place of Presentation: 松江
  • Year and Date: 20060921-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] CRFは両生類下垂体から2型受容体を介してTSHを放出させる (2006)
  • Author(s): 岡田 令子、小林 哲也、Miller Mark、山本 和俊、Denver Robert、菊山 榮
  • Organizer: 日本動物学会第77回大会
  • Place of Presentation: 松江
  • Year and Date: 20060921-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression of arginine vasotocin receptors in the newt brain (2006)
  • Author(s): Hasunuma, I., Nakada, T., Toyoda, F., Yamamoto, K., Kikuyama, S.
  • Organizer: The 77th Annual Meeting of the Zoological Society of Japan
  • Place of Presentation: Matsue
  • Year and Date: 20060921-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Female attracting activity of steroidal substances released from the abdominal gland of the male newt (2006)
  • Author(s): Toyoda, F., Haraguchi, S., Matsunaga, M., Tsutsui, K., Nakada, T., Nakamura, M., Yamamoto, K., Kikuyama, S.
  • Organizer: The 77th Annual Meeting of the Zoological Society of Japan
  • Place of Presentation: Matsue
  • Year and Date: 20060921-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Evidence for processing enzymes in the abdominal gland of the newt, Cynops pyrrhogaster. That generate sodefrin from its biosynthetic precursor. (2006)
  • Author(s): Nakada, T., Toyoda, F., Iwata, T., Ishizuka, Y., Kato, T., Kikuyama, S.
  • Organizer: The 77th Annual Meeting of the Zoological Society of Japan
  • Place of Presentation: Matsue
  • Year and Date: 20060921-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Melatonin elicits the expression of frog growth hormone releasing peptide in the frog brain (2006)
  • Author(s): Chowdhury, VS., Ukena, K., Hasunuma, I., Yamamoto, K., Kikuyama, S., Tsutsui, K.
  • Organizer: The 77th Anniial Meeting of the Zoological Society of Japan
  • Place of Presentation: Matsue
  • Year and Date: 20060921-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Changes in the expression of corticotropin releasing factor in the brain of metamorphosing bullfrog larvae (2006)
  • Author(s): Hashimoto, S., Okada, R., Mochida, S., Uchiyama, M., Kikuyama, S., Matsuda, K.
  • Organizer: The 77th Annual Meeting of the Zoological Society of Japan
  • Place of Presentation: Matsue
  • Year and Date: 20060921-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The release of TSH induced by corticotropin releasing factor from the bullfrog pituitary is mediated through the type 2 receptor (2006)
  • Author(s): Okada, R., Kobayashi, T., Miller, M., Yamamoto, K., Denver, R., Kikuyama, S.
  • Organizer: The 77th Annual Meeting of the Zoological Society of Japan
  • Place of Presentation: Matsue
  • Year and Date: 20060921-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] A possible synergistic action of sodefrin and steroidal substances to attract female newts (2006)
  • Author(s): Kikuyama, s., Toyoda, F., Haraguchi, S., Matsunaga, M., Yamamoto, K., Tsutsui, K.
  • Organizer: 3rd Conference of European Comparative Endocrinologists
  • Place of Presentation: Manchester
  • Year and Date: 20060829-0902
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Localization of two types of Arginine vasotocin receptor in the newt brain (2006)
  • Author(s): Hasunuma, I., Nakada, T., Sakai, T., Toyoda, F., Yamamoto, K., Kikuyama, S.
  • Organizer: 3rd Conference of European Comparative Endocrinologists
  • Place of Presentation: Manchester
  • Year and Date: 20060829-0902
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Stimulation of thyrotropin release from the bullfrog pituitary by PACAP and VIP (2006)
  • Author(s): Okada, R., Yamamoto, K., Chartrel, N., Fournier, A, Naudry, H., Kikuyama, S.
  • Organizer: 3rd Conference of European Comparative Endocrinologists
  • Place of Presentation: Manchester
  • Year and Date: 20060829-0902
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A possible synergistic action of, sodefrin and steroidal substances to attract female newts. (2006)
  • Author(s): Kikuyama, s., Toyoda, F., Haraguchi, S., Matsunaga, M., Yamamoto,K., Tsutsui, K
  • Organizer: 23rd Conference of European Comparative Endocrinologists.
  • Place of Presentation: Manchester
  • Year and Date: 20060829-0902
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Localization of two types of Arginine vasotocin receptor in the newt brain. (2006)
  • Author(s): Hasunuma, I., Nakada, T.,Sakai, T.,Toyoda, F.,Yamamoto, K, Kikuyama, S.
  • Organizer: 23rd Conference of European Comparative Endocrinologists.
  • Place of Presentation: Manchester
  • Year and Date: 20060829-0902
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Stimulation of thyrotropin release from the bullfrog pituitary by PACAP and VIP (2006)
  • Author(s): Okada, R.,Yamamoto, K., Chartrel, N.,Fournier, A, Vaudry, H., Kikuyama, S.
  • Organizer: 23rd Conference of European Comparative Endocrinologists.
  • Place of Presentation: Manchester
  • Year and Date: 20060829-0902
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Recently discovered hormonal and pheromonal substances in amphibians (2006)
  • Author(s): Kikuyama, S.
  • Organizer: Sixth International Congress of Neuroendocrinology
  • Place of Presentation: Pittsburgh
  • Year and Date: 20060619-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression of two types of arginine vasotocin receptor mRNA in the newt brain (2006)
  • Author(s): Hasunuma, I., Nakada, T., Toyoda, F., Yamamoto, K., Kikuyama, S
  • Organizer: Sixth International Congress of Neuroendocrinology
  • Place of Presentation: Pittsburgh
  • Year and Date: 20060619-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Signal transduction pathways for sodefrin in vomeronasal cells of the female newt,Cynopspyrrhogaster (2006)
  • Author(s): Nakada, T., Iwata, T., Kaneko, M., Yada, T., Shioda, S., Kikuyama, S
  • Organizer: Sixth International Congress of Neuroendocrinology
  • Place of Presentation: Pittsburgh
  • Year and Date: 20060619-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Identification of thyrotropin-releasing factor in amphibians (2006)
  • Author(s): Okda, R., Ito, Y., Yamamoto, K., Kikuyama, S
  • Organizer: Sixth International Congress of Neuroendocrinology
  • Place of Presentation: Pittsburgh
  • Year and Date: 20060619-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Thyroid hormone and bisphenol A act differently on the pituitary to suppress the release of thyrotropin (2006)
  • Author(s): Kaneko, M., Okada, R., Nakada, T., Yamamoto, K., Nakamura, M., Kikuyama, S
  • Organizer: Sixth International Congress of Neuroendocrinology
  • Place of Presentation: Pittsburgh
  • Year and Date: 20060619-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Recently discovered hormonal and pheromonal substances in amphibians. (2006)
  • Author(s): Kikuyama, S
  • Organizer: Sixth International Congress of Neuroendocrinology
  • Place of Presentation: Pittsburgh
  • Year and Date: 20060619-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Signal transduction pathways for sodefrin in vomeronasal cells of the female newt, Cynops pyrrhogaster (2006)
  • Author(s): Nakada, T, Iwata, T., Kaneko, M., Yada, T., Shioda, S., Kikuyama, S.
  • Organizer: Sixth International Congress of Neuroendocrinology
  • Place of Presentation: Pittsburgh
  • Year and Date: 20060619-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Thyroid hormone and bisphenol A act differently on the pituitary to suppress the release of thyrotropin. (2006)
  • Author(s): Kaneko, M., Okada, R., Nakada, T., Yamamoto, K., Nakamura, M., Kikuyama, S.
  • Organizer: Sixth International Congress of Neuroendocrinology
  • Place of Presentation: Pittsburgh
  • Year and Date: 20060619-22
  • Description: 「研究成果報告書概要(欧文)」より