2007 Fiscal Year Final Research Report Summary
The study of molecular mechanisms governing stem cell niche maintenance
| Project/Area Number |
18570194
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto University |
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Principal Investigator |
KAWASE Eihachiro Kyoto University, DEPARTMENT OF DEVELOPMENT AND DIFFERENTIATION, LECTURER (70402790)
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| Project Period (FY) |
2006 – 2007
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| Keywords | stem cell / niche / germ cell |
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| Research Abstract |
Stem cells are responsible for replacing damaged or dying cells in various adult tissues throughout a lifetime. They possess great potential for further regenerative medicine. However, the molecular mechanisms governing stem cell regulation are still poorly understood. It is well thought that stem cell behavior is controlled by specialized microenvironments called niche. The Drosophila testis has provided one of the excellent stem cell systems to study how this niche regulates stem cell self-renewal, differentiation and proliferation.
We and many other researchers demonstrated that both BMP-smad and JAK-STAT signaling are essential for maintaining germ-line stem cells in the Drosophila testis. In this study, we showed that localization of BMP using several different approaches. We also showed that and indirectly JAK-STAT signaling is required for the maintenance of germ-line stem cells.
Furthermore, we have tried to introduce the niche concept in embryonic stem cells in culture.
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[Journal Article] Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary.2008
Author(s)
Jin, A., Kirilly, D., Weng, C, Kawase, E., song, X., smith, S., Schwartz, J., Xie, T.
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Journal Title
Cell Stem Cell 2
Pages: 39-49
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells.2008
Author(s)
Miyazaki, T., Futaki, S., Hasegawa, K., Kawasaki, M., Sanzen, N., Hayashi, M., Kawase, E., Sekiguchi, K., Nakatsuji, N., Suemori, H.
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Journal Title
Biochem Biophys Res Commun. 375
Pages: 27-32
Description
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[Journal Article] The effects of extracellular matrices and growth factors on the hepatic differentiation of human embryonic stem cells.2008
Author(s)
Ishii, T., Fukumitsu, K., Yasuchika, K., Adachi, K., Kawase, E., Suemori, H., Nakatsuji, N., Ikai, I., Uemoto, S.
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Journal Title
Am. J Physiol. Gastrointest. Liver Physi 295
Pages: G313-G321
Description
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[Journal Article] Establishment of the gene-inducible system in primate embryonic stem cell lines.
Author(s)
Adachi, K., Kawase, E., Yasuchika, K., Sumi, T., Nakatsuji, N., Suemori, H.
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Journal Title
Stem Cells 24
Pages: 2566-2572
Description
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