2007 Fiscal Year Final Research Report Summary
DYNAMICS OF THE FOREGUT FORMATION
| Project/Area Number |
18570205
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
FUKUDA KIMIKO Tokyo Metropolitan University, 理工学研究科, ASSOCIATE PROFESSOR (40285094)
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| Project Period (FY) |
2006 – 2007
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| Keywords | DIGESTIVE TRACT / ENDODERM / MICROARRAY / CELL MOVEMENT / REGIONALIZATION / CELL LABELLING |
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| Research Abstract |
In chicken embryo, the definitive endoderm which gives rise to the epithelial lining of the digestive tract is established during gastrulation from epiblast. At the beginning, endoderm forms as an unspecified simple flat-sheet structure, and gradually becomes regionalized into antero-posteriorly and dorso-ventrally divided organs during embryogenesis. Finally, endodermal epithelium in each organ exhibits unique morphologies and gene expression patterns to perform its specific physiological functions. It is reported that the endoderm is necessary for the specification of other tissues such as forebrain, heart and inner ear. Therefore, to understand the detailed mechanisms of the endodermal specification is very helpful in clarifying the whole body plan in vertebrates. However, little is known about mechanisms underlying the initial steps of the regional differentiation (regionalization) in the endoderm. In this thesis I investigated to elucidate the timing of regionalization of endoderm, and molecular mechanisms essential for the early regionalization in endoderm.
This study clarified the precise timing of specification in foregut and hindgut endoderm, and based on these results, revealed the expression profile of many novel genes which may be important for the initial regionalization in endoderm. Moreover, the results I obtained that the signaling modifier of BMPs, sizzled, plays an essential role for regionalization of foregut, especially in liver development, illuminate importance of modification of the gradient of secreted molecules in specification of complex morphogenesis. The study presented here must provide a framework for further elucidation of molecular mechanisms underlying the differentiation along the body axis at early stage development not only in endoderm, but also whole body of the vertebrate.
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Research Products
(38 results)
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[Journal Article] Identification of region specific genes in early chicken endoderm.2008
Author(s)
Kimura, W., Cantas, A., Sheng, G., Jakt, M., Yasugi, S., Fukuda
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Journal Title
Gene Expression Patterns (in press)
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Tokyo Metropolitan University2007
Author(s)
Takemasa, T., Kimura, Y., Yasugi, S., Fukuda., K
Organizer
Isolation of genes expressed in early endoderm of chicken embryo. Bio-conference 2007
Place of Presentation
Tokyo
Year and Date
20071000
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Analysis of mechanisms for regionalization of the pancreas in early chick embryos.2007
Author(s)
Katsumoto, K., Fukuda, K., Kimura, W., Shimamura, K., Yasugi, S., Kume., S
Organizer
40th Annual Meeting of Japanese Society of Developmental Biologist
Place of Presentation
Fukuoka
Year and Date
20070500
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Analysis of the origin and the migratory route of the pancreas precursors in early chick embryos2006
Author(s)
Katsumoto, K., Fukuda, K., Kimura, W., Shimamura, K., Yasugi, S.and Kume, S.
Organizer
Intern.Congr.Biochem.Mol.Biol.
Place of Presentation
Kyoto
Year and Date
20060600
Description
「研究成果報告書概要(和文)」より
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[Presentation] Analysis of the origin and the migratory route of the pancreas precursors in early chick embryos.2006
Author(s)
Katsumoto, K., Fukuda, K., Kimura, W., Shimamura, K., Yasugi, S., Kume, S
Organizer
International Congress of Biochemistry and Molecular Biology
Place of Presentation
Kyoto
Year and Date
20060600
Description
「研究成果報告書概要(欧文)」より
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