2007 Fiscal Year Final Research Report Summary
Prevention of metabolic syndrome using food factors
| Project/Area Number |
18580133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Chubu University |
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Principal Investigator |
TSUDA Takanori Chubu University, College of Bioscience and Biotechnology, Associate Professor (90281568)
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| Project Period (FY) |
2006 – 2007
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| Keywords | metabolic syndrome / adiponectin / food factor / adipocyte / diabetes |
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| Research Abstract |
Adipocyte dysfunction is strongly associated with the development of obesity and insulin resistance. It is accepted that the regulation of adipocytokine expression is one of the most important targets for the prevention of obesity and improvement of insulin sensitivity. In this study, we have demonstrated that anthocyanin (cyanidin 3-glucoside; C3G) which is a pigment widespread in the plant kingdom, ameliorates hyperglycemia and insulin sensitivity due to the reduction of retinol binding protein 4 (RBP4) expression in type2 diabetic mice. These findings indicate that C3G has significant potency in an anti-diabetic effect through the regulation of Glut4-RBP4 system and the related inflammatory adipocytokines.
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[Journal Article] Enhanced absorption of anthocyanins after oral administration of phytic acid in rats and humans2007
Author(s)
Matsumoto, H., Ito, K., Yonekura K., Tsuda, T., Ichiyanagi, T., Hirayama, M., Konishi, T.
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Journal Title
J. Agric. Food Chem 55
Pages: 2489-2496
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice.2007
Author(s)
Sasaki, R., Nishimura, N., Hoshino H., Isa, Y., Kadowaki, M., Ichi, T., Tanaka, A., Nishiumi, S., Fukuda, I., Ashida, H., Horio, F., Tsuda, T.
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Journal Title
Biochem. Pharmacol. 74
Pages: 1619-1627
Description
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[Journal Article] Ingested delphinidin-3-rutinoside is primarily excreted to urine as the intact form and to bile as the methylated form in rats.2006
Author(s)
Matsumoto, H., Ichiyanagi, T., Iida, H., Ito, K., Tsuda, T., Hirayama, M., Konishi, T.
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Journal Title
J. Agric. Food Chem. 54
Pages: 578-582
Description
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