2007 Fiscal Year Final Research Report Summary
Studies on Novel Anti-Cancer Drugs binding to Allosteric site
| Project/Area Number |
18590099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Kumamoto Health Science University |
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Principal Investigator |
OKAWARA Takashi Kumamoto Health Science University, Faculty of Health Science, Professor (60040325)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Moleculat Targeted Drug / mutation / allosteric inhinition / Galloyl group / structure optimization / anti-cancer drug / docking / hetero ring |
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| Research Abstract |
After anti-cancer drugs are used, cancers quickly mutate into resistant form against them. Drugs were designed to bind to allosteric site by using molecular docking method. Candidate compounds were selected, prepared, and assayed using topoisomerase and cancer cell lines. Results showed to inhibit the cancer growth.
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