2009 Fiscal Year Final Research Report
Analysis of the early liver morphogenesis during the embryonic period
| Project/Area Number |
18590171
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Osaka City University |
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Principal Investigator |
NAKATANI Kazuki Osaka City University, 大学院・医学研究科, 講師 (60295699)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 発生 / 分化 / 細胞 / 組織 / 解剖学 / 細胞間結合 |
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| Research Abstract |
To reveal the process of hepatoblast differentiation and hepatoblastic tissue construction, I analyzed the embryonic and fetal liver using immunohistochemical and ultrastructural methods. Hepatoblasts become to be expressed N-cadherin, a molecule in adherence junction, when they are differentiated from endodermal epithelia of foregut. And N-cadherin is detected in hepatoblasts and fetal hepatocytes throughout embryonic and fetal period. I also revealed that hepatoblasts keep adherence junction between them during moving in transverse septum.
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[Journal Article] Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis.2007
Author(s)
Otogawa K, Kinoshita K, Fujii H, Sakabe M, Shiga R, Nakatani K, Ikeda K, Nakajima Y, Ikura Y, Ueda M, Arakawa T, Hato F, Kawada N
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Journal Title
J Am Pathol 170(3)
Pages: 967-980
Peer Reviewed
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