2007 Fiscal Year Final Research Report Summary
Aberrant migration of primordial germ cells in the Sox 17^<-/-> mouse embryos
| Project/Area Number |
18590175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kyorin University |
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Principal Investigator |
KANAI Masami Kyorin University, Faculty of Medicine, Assistant professor (70321883)
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| Co-Investigator(Kenkyū-buntansha) |
YONEKAWA Hiromichi Tokyo Metropolitan Institute of Medical Science, 東京都臨床医学研究所, Vice director (30142110)
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| Project Period (FY) |
2006 – 2007
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| Keywords | endoderm / mouse / development and differentiation / gut formation / germ cells |
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| Research Abstract |
The Sox (Sryrelated HMG box) gene family was first identified through its homology to the high mobility group (HMG) box of the sex detemininating gene of SRY In this project, we have studied that the role of Sox17 on the mouse endoderm, and especially of interaction between primodial germ cells (PGCs) and primary gut. The migration of PGCs are observed after the gastrulaion stage of the embryo and they have moved from allantois to the genital ridge through hind gut. PGCs are initially highly motile but restricted to the hindgut region, from where they then migrate out and accumulate in the genital ridge. However, the mutant of Sox17 shows the accumulation of PGCs around the allantois. The number of PGCs are not affected by Sox17 null mutant. Therefore, we have generated the chimera between CAG-EGFP blastocyst and Sox 17-/- ES cells, and observed the ineraction of PGCs and hindgut cells.
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[Journal Article] Potency of testicular enviroment to support spermatogenesis in XX/Sry transgenic male mice2007
Author(s)
Ishii, M., Tachiwana, T., Hoshino, A., Tsunekawa, N., Hiramatsu, R., Matoba, S., Kanai-Azuma, M., Kawakami, H., Kurohmaru, M., Kanai, Y
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Journal Title
Development 134
Pages: 449-454
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Identification of Sox17 as a transcription factor that regulates oligodendrocyte development2006
Author(s)
Sohn, J., Chew, L., Cheng, Y., Lytle, J., Oumesmar, B., Kanai-Azuma, M., Kanai, Y., Gallo, V
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Journal Title
J Neuro sci 26 (38)
Pages: 9722-9735
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Aberrant migration of primordial germ cells in the Sox17^<-/-> mouse embryos2007
Author(s)
Hara, K., Tsunekawa, N., Watanabe, Y., Sakamoto, Y., Miura, Y., Kanai-Azuma, M., Kurohmaru, M., Kanai, Y
Organizer
40th Japanese Society of Deleopmental Biology
Place of Presentation
Fukuoka
Year and Date
20070528-30
Description
「研究成果報告書概要(欧文)」より
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[Presentation] The role os Sox17 and Sox18 in mouse embryonic cardiocasculogenesis2006
Author(s)
Sakamoto, Y., Matui, T., Hara, K., Nagata, T., Tsunekawa, N., Kanai-Azuma, M., Kanai, Y., Kurohmaru, M
Organizer
141th Japanse society of Veterinary Science
Place of Presentation
EPOCAL TSUKUBA
Year and Date
20060319-21
Description
「研究成果報告書概要(欧文)」より
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