Study on self-regeneration of the central nervous system by perineuronal progenitor cell

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 18590191
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Osaka City University
• Principal Investigator: KATAOKA Yosuke Osaka City University, Graduate School of Medicine, Lecturer (40291033)
• Project Period (FY): 2006 – 2007
• Keywords: perineuronal progenitor cell / proliferation / differentiation / central nervous system / cerebral cortex / oligodendrocyte / repair / progenitor cell

Research Abstract

In the rat cerebral cortex, cells which exist around neuronal cell somata and have a potent proliferative activity were found. We named the cells "perineuronal progenitor cells". The perineuronal progenitor cells differentiated into immature inhibitory neurons and astrocytes as well as oligodendrocytes, under physiological condition. The cells showed the facilitation of proliferation under neuronal degeneration or excessive excitation of neurons. These results indicated that the perineuronal progenitor cells play an important role in tissue repair of the central nervous system.
We explored substances which induce proliferation or differentiation of the perineuronal progenitor cells by using a DNA mic roarray system, and could find some substances. The number of the perineuronal progenitor cells decreased in aged animals. This phenomenon suggests that the cells are involved in atrophy of the brain or cognitive disfunction. More studies on the cells will bring about new concepts on mechanism of the occurrence of neurological disorders.

Research Products

• [Journal Article] 分子イメージング研究による創薬・疾患診断の革新 (第44回(2007年度)ベルツ賞受賞論文) (2008)
  • Author(s): 渡辺 恭良、鈴木 正昭、尾上 浩隆、土居 久志、和田 康弘、片岡 洋祐、榎本 秀一
  • Journal Title: 最新医学 63 Pages: 116-138
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 分子イメージング研究による創薬・疾患診断の革新 (第44回(2007年度)ベルツ賞受賞論文) (2008)
  • Author(s): 渡辺 恭良、鈴木 正昭、尾上 浩隆、土居 久志、和田 康弘、片岡 洋祐、榎本 秀一
  • Journal Title: 日本医師会雑誌 136 Pages: 2469-2474
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 抗疲労(アンチファティーグ)、アンチエイジング研究の接点 (2008)
  • Author(s): 福田 早苗、片岡 洋祐、渡辺 恭良
  • Journal Title: Anti-AgingMedicine (日本抗加齢医学会雑誌) 4 Pages: 26-31
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Innovation of drug development and pathophysiological diagnosis using molecular imaging technique (2008)
  • Author(s): Watanabe, Y., Suzuki, M., Onoe, H., Doi, H., Wada, Y., Kataoka, Y., Enomoto, S
  • Journal Title: Med. Frontline 63 Pages: 116-138
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential expression of nuclear lamin,the major component of nuclear lamina,during neurogenesis in two germinal regions of adult rat brain. (2007)
  • Author(s): Takamori Y., Kataoka Y., et. al.
  • Journal Title: Eur. J. Neurosci. 25 Pages: 1653-1662
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Multi-directional differentiation of doublecortin- and NG2-immunopositive progenitor cells in the adult rat neocortex in vivo. (2007)
  • Author(s): Tamura, Y., Kataoka, Y., et. al.
  • Journal Title: Eur. J. Neurosci. 25 Pages: 3489-3498
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Intracellular translocation of glutathione S-transferase pi during oligodendrocyte differentiation in the adult rat cerebral cortex invivo. (2007)
  • Author(s): Tamura, Y., Kataoka, Y., et. al.
  • Journal Title: Neuroscience 148 Pages: 535-540
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Upregulated neuronal COX-2 expression after cortical spreading depression is involved in non-REM sleep induction in rats. (2007)
  • Author(s): Cui, Y., Kataoka, Y., et. al.
  • Journal Title: J.Neurosci.Res. 86 Pages: 929-936
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 低反応レベルレーザーの鎮痛機序 (2007)
  • Author(s): 片岡 洋祐
  • Journal Title: 痛みと臨床 7 Pages: 127-131
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 光技術を用いた中枢神経活動・代謝制御 (2007)
  • Author(s): 片岡 洋祐
  • Journal Title: レーザー研究 35 Pages: 453-456
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] レーザーによる神経機能調節とそのメカニズム (2007)
  • Author(s): 片岡 洋祐
  • Journal Title: レーザー歯学会誌 18 Pages: 93-96
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential expression of nuclear lamin, the major component of nuclear lamina, during neurogenesil in two germinal regions of adult rat brain (2007)
  • Author(s): Takamori, Y., Kataoka, Y, et. al.
  • Journal Title: Eur. J. Neurosci 25 Pages: 1653-1662
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Multi-directional differentiation of doublecortin- and NG2-immunopositive progenitor cells in the adult rat neocortex in vivo (2007)
  • Author(s): Tamura, Y., Kataoka, Y., et. al.
  • Journal Title: Eur. J. Neurosci 25 Pages: 3489-3498
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Intracellular translocation of glutathione S-transferase pi during oligodendrocyte differentiation in the adult rat cerebralcortex in vivo (2007)
  • Author(s): Tamura, Y., Kataoka, Y., et. al.
  • Journal Title: Neuroscience 148 Pages: 535-540
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Upregulated neuronal COX-2 expression after cortical spreading depression is involved in non-REM sleep induction in rats (2007)
  • Author(s): Cui, Y., Kataoka, Y., et. al.
  • Journal Title: J. Neurosci. Res 86 Pages: 929-936
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] mechanism of pain relief by low-reactive level laser (2007)
  • Author(s): Kataoka, Y
  • Journal Title: J. Pain Clin. Med 7 Pages: 127-131
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Control of activity and metabolism of the central nervous system by photo-technology (2007)
  • Author(s): Kataoka, Y
  • Journal Title: Rev. Laser Eng 35 Pages: 453-456
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Control of neural function by laser and the mechanism (2007)
  • Author(s): Kataoka, Y
  • Journal Title: J. Jpn. Soc. Laser Dent 18 Pages: 93-96
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neuroprotection by a central nervous system-type prostacyclin receptor ligand demonstrated in monkeys subjected to middle cerebral artery ocelusion and reperfusion:A positron emission tomography study. (2006)
  • Author(s): Cui Y., Takamatsu, H., et. al.
  • Journal Title: Stroke 37 Pages: 2830-2836
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Neuroprotection by a central nervous system-type prostacyclin receptor ligand demonstrated in monkeys subjected to middle cerebral artery occlusion and reperfusion: A positron emission tomography study (2006)
  • Author(s): Vui, Y., Takamatsu, H, et. al.
  • Journal Title: Stroke 37 Pages: 2380-2386
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Strategiess pecifically designed for supporting the academic motivation of individual college students.
  • Author(s): Yoshida, M., Tanaka, M., et. al.
  • Journal Title: Intl. J. Neurosci. (In press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of sensory denervation by neonatal capsaicin administration on experimental pacreatitis induced by dibutyltin dichloride.
  • Author(s): Ikeura, T., Kataoka, Y., et. al.
  • Journal Title: Med.Mol.Morphol. (In press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of (-)-epigallocatechin gallate in liver of an animal model of combined (physical and mental)fatigue.
  • Author(s): Tanaka, M., Baba, Y., et. al.
  • Journal Title: Nutrition (In press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Strategies specifically designed for supporting the academic motivation of individual college students
  • Author(s): Yoshida, M., Tanaka, M., et. al.
  • Journal Title: Intl. J. Neurosci (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of sensory denervation by neonatal capsaicin administration on experimental pacreatitis induced by dibutyltin dichloride
  • Author(s): Ikeura, T., Kataoka, Y., et. al.
  • Journal Title: Med. Mol. Morphol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of (-)-epigallocatechin gallate in liver of an animal model of combined (physical and mental) fatigue
  • Author(s): Tanaka, M., Baba, Y., et. al.
  • Journal Title: Nutrition (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 中枢神経興奮後の疲労と睡眠誘発(シンポジウム) (2008)
  • Author(s): 片岡 洋祐、崔 翼龍、田村 泰久、大和 正典、金光 華、渡辺 恭良
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京・京王プラザホテル東京
  • Year and Date: 20080325-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 各種疲労モデル動物を用いた疲労の分子・神経メカニズム研究の概要(シンポジウム) (2008)
  • Author(s): 片岡 洋祐、大和 正典、金光 華、渡辺 恭良
  • Organizer: 第4回日本疲労学会
  • Place of Presentation: 熊本・熊本県立劇場
  • Year and Date: 20080215-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 劇症疲労ラットのヘム代謝異常とその疲労への関与(シンポジウム) (2008)
  • Author(s): 岩井 一宏、植田 亮、下畑 宣行、坂田 真一、片岡 洋祐、今岡 進、渡辺 恭良
  • Organizer: 第4回日本疲労学会
  • Place of Presentation: 熊本・熊本県立劇場
  • Year and Date: 20080215-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 感染疲労モデル動物における自発行動の抑制と脳組織内c-Fos発現 (2008)
  • Author(s): 金光 華、江口 麻美、大和 正典、奥山 香里、田中 雅彰、片岡 洋祐、渡辺 恭良
  • Organizer: 第4回日本疲労学会
  • Place of Presentation: 熊本・熊本県立劇場
  • Year and Date: 20080215-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 感染疲労モデル動物における一酸化窒素合成酵素(NOS)の役割 (2008)
  • Author(s): 大和 正典、金光 華、奥山 香里、江口 麻美、片岡 洋祐、渡辺 恭良
  • Organizer: 第4回日本疲労学会
  • Place of Presentation: 熊本・熊本県立劇場
  • Year and Date: 20080215-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Studies on molecular and neural mechanisms of fatigue using animal models for fatigue (2008)
  • Organizer: Jpn. Soc. For Fatigue Sci
  • Year and Date: 20080215-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Abnormal hem metabolism and fatigue in fatigued rats (2008)
  • Author(s): Iwai, K, et. al.
  • Organizer: Jpn. Soc. For Fatigue Sci
  • Year and Date: 20080215-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Depressive behavior and brain c-Fos expression in immunologically-fatigued rats (2008)
  • Organizer: Jpn. Soc. For Fatigue Sci
  • Year and Date: 20080215-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The role of NOS in immunologically-fatigued rats (2008)
  • Organizer: Jpn. Soc. For Fatigue Sci
  • Year and Date: 20080215-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 低反応レベルレーザを用いた神経興奮・代謝調節(シンポジウム) (2008)
  • Author(s): 片岡 洋祐、田村 泰久、小田-望月 紀子
  • Organizer: 第28回日本レーザー学会年次大会
  • Place of Presentation: 名古屋・名古屋国際会議場
  • Year and Date: 20080130-0201
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Control of Neural activity and metabolism using low-reactive level laser (2008)
  • Author(s): Kataoka, Y., et. al.
  • Organizer: Laser Soc. of Jpn.
  • Year and Date: 20080130-0201
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Brain serotonergic nervous system modulates cortical spreading depression: A pathophysiology of migraine. (2007)
  • Author(s): Cui, Y., Tamura, Y., Kataoka, Y., Watanabe Y.
  • Organizer: Society for Neuroscience 2007
  • Place of Presentation: San Diego,USA
  • Year and Date: 20071103-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Multi-directional differentiation of cortical progenitor cells co-expressing doublecortin and NG2 in the adult rats. (2007)
  • Author(s): Tamura, Y., Cui, Y., Watanabe Y., Kataoka, Y.
  • Organizer: Society for Neuroscience 2007
  • Place of Presentation: San Diego,USA
  • Year and Date: 20071103-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Perineuronal germinal cells in the cerebral cortex of adult rats. (2007)
  • Author(s): Kataoka, Y., Tamura, Y., Cui, Y., Watanabe Y., Yamada H.
  • Organizer: Society for Neuroscience 2007
  • Place of Presentation: San Diego,USA
  • Year and Date: 20071103-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 老齢ラット大脳皮質におけるNG2陽性細胞の領域特異的な変化について (2007)
  • Author(s): 田村 泰久、崔 翼龍、渡辺 恭良、片岡 洋祐
  • Organizer: 第30回日本神経科学会・第50回日本神経化学会・第17回日本神経回路学会合同大会(Neuro2007)
  • Place of Presentation: 横浜・パシフィコ横浜
  • Year and Date: 20070910-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] MicroPETを用いた片頭痛病態モデルの評価 (2007)
  • Author(s): 崔 翼龍、和田 康弘、大和 正典、田村 泰久、片岡 洋祐、渡辺 恭良
  • Organizer: 第30回日本神経科学会・第50回日本神経化学会・第17回日本神経回路学会合同大会(Neuro2007)
  • Place of Presentation: 横浜・パシフィコ横浜
  • Year and Date: 20070910-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Region-specific degeneration of NG2 cells in the cerebral cortex of aged rats (2007)
  • Author(s): Tamura, Y., Cui, Y., Watanabe, Y., Kataoka, Y
  • Organizer: Neuro 2007
  • Year and Date: 20070910-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Evaluation of pathophysiological features of migraine by micro PET study using rats (2007)
  • Author(s): Cui, Y., Wada Y., Yamato, M., Tamura, Y., Kataoka, Y., Watanabe, Y
  • Organizer: Neuro 2007
  • Year and Date: 20070910-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ラット水泳筋疲労におけるフルスルチアミンの抗疲労効果 (2007)
  • Author(s): 金光 華、大和 正典、奥山 香里、江口 麻美、野崎 聡、片岡 洋祐、秋元 浩二、北吉 正人、渡辺 恭良
  • Organizer: 第3回日本疲労学会
  • Place of Presentation: 東京・東京医科大学
  • Year and Date: 20070630-0701
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Anti-fatigue effects of fursulthiamine on muscle fatigue of swimming rats (2007)
  • Author(s): Jin, G., Yamato, M., Okuyama, K., Eguchi, A., Nozaki, S., Kataoka, Y., et. al.
  • Organizer: Jpn. Soc. Fatigue Sci
  • Year and Date: 20070630-0701
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] インドメタシン誘起小腸潰瘍の[^<18>F]FDGイメージング (2007)
  • Author(s): 大和 正典、片岡 洋祐、水間 広、和田 康弘、渡辺 恭良
  • Organizer: 第2回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 福井・フェニックスプラザ
  • Year and Date: 20070628-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] FDG imaging of indomethacin-induced intestinal ulceration (2007)
  • Author(s): Yamato, M., Kataoka, Y., Mizuma, H., Wada, Y., Watanabe, Y
  • Organizer: Jpn. Soc. For Mol. Imaging
  • Year and Date: 20070628-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Fatigue and sleep induction following excessive activation of central nervous system
  • Author(s): Kataoka, Y., et. al.
  • Organizer: Annual meeting of Physiological Soc.of Jpn
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Innovation of drug development and pathophysiological diagnosis using molecular imaging technique (2008)
  • Author(s): Watanabe, Y., Suzuki, M., Onoe, H., Doi, H., Wada, Y., Kataoka, Y., Enomoto, S
  • Total Pages: 2469-2474
  • Publisher: J. Jpn. Med. Association
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] The contact of anti-fatigue and anti-aging (2008)
  • Author(s): Fukuda, S., Kataoka, Y., Watanabe, Y
  • Total Pages: 26-31
  • Publisher: Anti-aging Med
  • Description: 「研究成果報告書概要(欧文)」より