2007 Fiscal Year Final Research Report Summary
A novelestrogen receptor in plasma membrane
| Project/Area Number |
18590205
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MIZUKAMI Yoichi Yamaguchi University, Center for Gene Res, Associated Prof (80274158)
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| Co-Investigator(Kenkyū-buntansha) |
SHINODA Koh Yamaguchi Univ, Dept. of Neurosci, Prof (40192108)
SUZUKI Harumi Yamaguchi University, Chief (70235985)
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| Project Period (FY) |
2006 – 2007
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| Keywords | estrogen / GPCR / GPR30 / KO mouse / KOマウス |
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| Research Abstract |
Recently, GPR30 was reported to be a novel estrogen receptor; however, its physiological roles has remained controversial. To investigate the roles of GPR30 in vivo, we produced the conditional knocked out mice for GPR30. Chimera mice were bore more than 70 %, but the transgene of the chimera mice were unobserved in the newborn mice. In clinical patients, we try to develop the protocol for detection of the mutation in GPR30 genome. We have detected the a few mutant of GPR30 genome. Immunohistochemical analysis shows that GPR30 exists in various tissues. These data indicate that GPR30, a transmembrane receptor for estrogen, may play a role in various tissues.
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[Journal Article] Hepatitis C virus-induced reactive oxygen species causes hepatic iron accumulation by reducing hepcidin transcription2008
Author(s)
Nishina, S., Hino, K., Korenaga, M., Pietrangelo, A., Mizukami., Y., Furutani, T., Sakai, A., Okuda, M., Hidaka, I., Okita, K., Sakaida, I
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Journal Title
Gastroenterology 134(1)
Pages: 226-238
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen2007
Author(s)
Hirata, T., Cui, J. Y., Funakoshi, T., Mizukami., Y., Ishikawa, Y., Shibasaki, F., Matsumoto, M., Sakabe, T
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Journal Title
Brain Res 1130(1)
Pages: 214-222
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Melanocortin receptor 2 is required for adrenal gland development, steroidogenesis and neonatal gluconeogenesis 33-Kinase2007
Author(s)
Dai, Chida, Shinichi, Nakagawa, So, Nagai, Hiroshi, Sagan, Harumi, Katsumata, Toshihiro, Imaki, Harumi, Suzuki, Fumiko, Mitani, Tadashi, Ogishima, Chikara, Shimizu, Hayato, Kotaki, Shigeru, Kakuta, Katsuko, Sudoa, Takao, Koike, Mitsumasa, Kubo, Yoichiro, Iwakura
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Journal Title
Proc. NaIL Acad. Sci. USA 104
Pages: 18205-18210
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] [Corresponding auhtor], Racl mediated Bcl-2 induction is critical in antigen-induced CD4 single positive differentiation of a CD4+CD8+ immature thymocyte line2007
Author(s)
Hiroyo, Oda, Harumi, Suzuki, Kouhei, Sakai, Seiji, Kitahara, Michael S., Patrick, Yoshinao, Azuma, Kazuro, Sugi, Toshio, Kitamura, Jonathan, Kaye, Mutsunori, Shirai
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Journal Title
J. Leuko. BioL 81
Pages: 500-508
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Lipopolysaccharide promotes NADPH oxidase-mediated production of 4-hydroxynonenal that modifies fragmented GRP78 in rat liver2008
Author(s)
Hiroko, Kimura, Masahiro, Mukaida, Yoichi, Mizukami, Nobuko, Kon, Kazuko, Matsumoto, Ken-ichi, Yoshida
Organizer
Biomarkers of Oxidative Stress in Health and Diseases
Place of Presentation
Osaka
Year and Date
20080116-19
Description
「研究成果報告書概要(欧文)」より
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[Presentation] PROTEOMIC ANALYSIS OF CEREBROSPINAL FLUID FROM PATIENTS WITH CARDIOPULMONARY RESUSCITATION2007
Author(s)
Tomonori, Izumi, Yasutaka, Oda, Tomoki, Katagiri, Yoichi, Mizukami, Yuki, Akiyoshi, Ryosuke, Tsuruta, Shunji, Kasaoka, Tsuyoshi, Maekawa
Organizer
HUPO 6th annual world congress
Place of Presentation
Soeul.,Korea
Year and Date
20071006-09
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Proteomics analysis in spinal marrow of cardiopulmonary arrest ; Identification of biomarker for neuronal diseases2007
Author(s)
Oda, T., Izumi., T., Katagiri, T., Mizukami, Y., Akiyoshi, Y., Maekawa, T
Organizer
21th IUBMB International Congress of Biochemistry and Molecular Biology
Place of Presentation
Yokohama
Year and Date
2007-12-11
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Comparative proteomics in rat brain by Q-TOF-MS/MS2007
Author(s)
Katagiri, T., Hatano, N., lzumi, T., Maekawa, T, Liu., X., Nakamura, S., Shirai, M., Mizukami, Y
Organizer
21th IUBMB International Congress of Biochemistry and Molecular Biology
Place of Presentation
Yokohama
Year and Date
2007-12-11
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Proteomics analysis in six regions of rat brain by nano-LC-Q-TOF-MS/MS2007
Author(s)
Katagiri, T., Hatano, N., Izumi, T., Maekawa, T., Liu., X., Nakamura, S., Shirai, M., Mizukami, Y
Organizer
Conference of Yamaguchi Medicine, 108
Place of Presentation
Yamaguchi
Year and Date
2007-07-14
Description
「研究成果報告書概要(欧文)」より
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