2007 Fiscal Year Final Research Report Summary
Pathological and molecular analysese of multiple esophageal cancers.
| Project/Area Number |
18590352
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Okinaka Memorial Institute for Medical Research |
|---|
Principal Investigator |
OHASHI Kenichi Okinaka Memorial Institute for Medical Research, Researcher (40231203)
|
|---|
| Project Period (FY) |
2006 – 2007
|
| Keywords | Esophagel cancers / Tongue cancers / Pharyngeal cancers / Larynffeal cancers / Multiple cancers / Early cancers / P53 protein |
|---|
| Research Abstract |
Squamous cell carcinoma of the esophagus is frequently originated from east Asian countries, such as China and Japan. Virus infection, alcohol drinking and smoking habit were assumed to be pathogenesis of esophageal cancers, however detailed mechanism of carcinogenesis has not been well understood yet. Aldo-keto reductase (AKR) is monomeric soluble NAD (P) H-dependent oxidoreductase that catalyzes the reduction of a variety of carbonyl compounds. AKRs are involved in elimination reactions, because they will often functionalize carbonyl groups on aldehydes or ketones to form primary or secondary alcohols. We recently identified high correlation between the overexpression of the AKR family 1 member B10 (AKR1B10) and smokers' non-small cell lung carcinomas. Especially in squamous cell carcinoma (SCC), overexpression of AKR1B10 was observed in a high incidence. The aim of current study was to analyze the expression of AKR1B10 in normal squamous epithelium and SCC or other lesions in esophagus and head and neck region. Immunohistochemistry was performed on total 289 specimens including non-neoplastic and pre-malignant lesions, esophageal SCC (ESCC) and head and neck SCC (HNSCC), using antibodies against AKR1B10. As the results, overexpression of AKR1 B10 showing the diffuse and strong immunoreactivity was observed only in SCCs, although some cases of non-neoplastic lesions and pre-malignant lesions showed significant overexpression. Interestingly, verrucous carcinoma demonstrated strong tendency to over-express AKR1B10 and well differentiated SCC also seemed to over-express more than moderate and poorly differentiated one. Our study shows that AKR1 B10 is a potently good diagnostic marker for ESCC and HNSCC. Moreover, we suggest the potential carcinogenic factor ofAKR1B10 about the significance of its overexpression, taken together with the results of this study and previous reports demonstrating the physiological function of AKR1 family.
|
