2007 Fiscal Year Final Research Report Summary
Analysis of Bone Marrow Derived Cells Homing to Gastric Cancer and metastasis
| Project/Area Number |
18590363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NOMURA Sachiyo The University of Tokyo, The University of Tokyo Hospital, Associate Professor (70301819)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Gastric Cancer / stem cell / carcinogenesis / bone marrow / clonality / bone marrow derived cell / esophageal cancer / metaplasia |
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| Research Abstract |
We analyzed whether gastric cancer is originated from bone marrow derived cells, using mouse chemical carcinogenesis model. Seventeen BALB/c male mice were irradiated 9 Gy and transplanted bone marrow cells extracted from GFP mice. They started drinking water including MNU 240 ppm after recovery from the damage of irradiation. They drank MNU for 5weeks every other week, durated for 9 weeks. 4 mice among 17 were spared for control, and 13 mice were applied MNU. After 40 weeks later from the beginning of taking MNU, they were sacrificed and the stomachs were excised. When the time of sacricficing, only 6 mice out of 13 were alive. Among them, 4 mice beared squamous cell carcinoma in the forestomach. Almost all the cancer cells were GFP negative and they were speculated to be derived from original stomach cells. However, only a small part of cancer cells were GFP positive and they were speculated from bone marrow derived cells. Lymph node metastasis were observed, but, they were GFP negative and there was no homing of bone marrow derived cells.
From the results of this experiment, not all the cancer is derived from bone marrow derived cells. However, there is still possibility that small part of cancer is originated from bone marrow derived cells. We need to research more to confirm the results. We could also show the possibility that cancer is not monoclonal.
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[Journal Article] Hclicobacter pylori-negative/API2-MALT1 translocation negative low-grade MALT lymphoma2006
Author(s)
Nozaki K, Nomura S, Shimizu N, Hiki N, Yoshizawa N, Aikou S, Kubota K, Yamaguchi H, Kurosaka H, Shinozaki A, Mafune K, Fukayama M, kaminishi M
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Journal Title
Gastric Cancer 9(3)
Pages: 229-234
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Helicobacter pylori-negative/API2-MALT1 translocationnegative low-grade MALT lymphoma2006
Author(s)
Nozaki K, Nomura S, Shimizu N, Hiki N, Yoshizawa N, Aikou S, Kubota K, Yamaguchi H, Kurosaka H, Shinozaki A, Mafune K, Fukayama M, kaminishi M
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Journal Title
Gastric Cancer 9(3)
Pages: 229-243
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Effect of Helicobacter Pylori Infection in Experimental Gastric Carcinogenesis of Mongolian Gerbila2006
Author(s)
Koji Nozaki, Xueyuan Cao, Harunari Tanaka, Yuzuru Ikehara, Tetsuya Tsukamoto, Hayao Nakanishi, Nobuyuki Shimizu, Sachiyo Nomura, Hirokazu Yamaguchi, Yoshio Yamaoka, Michio kaminishi, Masae Tatematsu
Organizer
DDW2006
Place of Presentation
Los Angeles, CA
Year and Date
2006-05-24
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Effect of Helicobacter Pylori Infection in Experimental Gastric Carcinogenesis of Mongolian Gerbils2006
Author(s)
Koji Nozaki, xueyuan Cao, Harunari Tanaka, Yuzuru Ikehara, Tetsuya Tsukamoto, Hayao Nakanishi, Nobuyuki Shimizu, Sachiyo Nomura, Hirokazu Yamaguchi, Yoshio Yamaoka, Michio kaminishi, Masae Tatematsu
Organizer
DDW
Place of Presentation
Los Angeles, CA
Year and Date
2006-05-22
Description
「研究成果報告書概要(和文)」より
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