2008 Fiscal Year Final Research Report
Development of DNA polymerase ι-deficient mice and characterization of their susceptibility to lung tumor development
Project/Area Number |
18590384
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Kochi University |
Principal Investigator |
LEE Gang-hong Kochi University, 教育研究部医療学系, 教授 (10261405)
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Project Period (FY) |
2006 – 2008
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Keywords | 腫瘍 / 発がん感受性 / 量的形質 / 連鎖解析 |
Research Abstract |
DNA ポリメラーゼイオタは、我々が発見した肺発がん抵抗性遺伝子座の有力な候補遺伝子である。この遺伝子の欠損が肺発がんに及ぼす影響を直接的に調べるため、DNAポリメラーゼイオタ欠損マウスの樹立を遺伝子工学技術によって試み、成功した。しかし、樹立の過程は様々な要因により当初計画よりも遅れを生じたため、3 年間の研究期間で肺発がん感受性実験の終了にまで至ることができなかった。2009 年度以降も外部資金獲得に努め、研究を継続する。
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Research Products
(32 results)
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[Journal Article] Carcinoid tumor of the renal pelvis : consideration on the histogenesis2008
Author(s)
Kuroda N, Katto K, TamuraM, Shiotsu T, Hes O, Michal M, Nagashima Y, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee G-H.
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Journal Title
Pathol Int. 58
Pages: 51-54
Peer Reviewed
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[Journal Article] Sarcomatoid acquired cystic disease-associated renal cell carcinoma2008
Author(s)
Kuroda N, Tamura M, Taguchi T, Tominaga A, Hes O, Michal M, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Shuin T, Lee G-H.
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Journal Title
Histol Histopathol 23
Pages: 1327-1331
Peer Reviewed
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[Journal Article] Mucinous tubular and spindle cell carcinoma with Fuhrman nuclear grade 3 : a histological, immunohistochemical, ultrastructural and FISH study2008
Author(s)
Kuroda N, Hes O, Michal M, Nemcova J, Gal V, Yamaguchi T, Kawada T, Imamura Y, Hayashi Y, Lee G-H.
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Journal Title
Histol Histopathol 23
Pages: 1517-1523
Peer Reviewed
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[Journal Article] H. An Asian variant of intravascular lymphoma : unique clinical and pathological manifestation in the gallbladder2007
Author(s)
Kuroda N, Mizobuchi M, Shimamura Y, Taniguchi Y, Daibata M, Miyoshi I, Ichimura T, Beppu H, Ohara M, Hirouchi T, Mizuno K, Lee G-H.
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Journal Title
Peer Reviewed
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[Journal Article] Renal leiomyoma : an immunohistochemical, ultrastructural and comparative genomic hybridization study2007
Author(s)
Kuroda N, Inoue Y, Taguchi T, Tominaga A, Hes O, Michal M, Hayashi Y, Hiroi M, Shuin T, Lee G-H.
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Journal Title
Histol Histopathol 22
Pages: 883-888
Peer Reviewed
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