2007 Fiscal Year Final Research Report Summary
Oxidization Stress and Genetic Polymorphism in Smoking
| Project/Area Number |
18590529
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
FUNATO Tadao Kyoto University, Graduate School of Medicine, Professor (70165455)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Masatoshi Kyoto University, Graduate School of Medicine, Professor (50190046)
TAKAHASHI Yuko Nara Woman's University, Health Administration Center, Professor (00346305)
IKEMOTO Masaki Kyoto University, Graduate School of Medicine, Associate Professor (80144385)
TAKEDA Mayu Kyoto University, Graduate School of Medicine, Assistant Technical Staff (00423054)
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| Project Period (FY) |
2006 – 2007
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| Keywords | smoking / oxidative stress / genetic polymorphism / GST / reactive oxygen species / PON1 |
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| Research Abstract |
Cigarette smoking causes oxidative stress in human both from the direct effects of the free radicals present in smoke. To study the effect of cigarette smoking, the levels of 8-hydroxy-2-deoxyguanosine (8OHdG) as the marker of an oxidative stress in smoking group have observed compared with those of non-smoker group, and may have been related to oxidative stress. We measured the levels of serum 8OHdG in all patients and control. In all, GST1, GSTM1, and PON1 Q192R genotypes were determined with PCR-RFLP analysis. Higher levels of 8OHdG in smoking group have observed significantly compared with those of non-smoker group. The frequencies of the genotype with the levels of 8OHdG did not be significantly related among the group. The present results suggest that GST1, GSTM1, and PON1 Q192R polymorphism is not associated with the level of 8OHdG between the smokers and non-smokers group.
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