2010 Fiscal Year Final Research Report
Molecular epidemiological analysis of the clinically isolated bacteria for the measurement of nosocomial infections
| Project/Area Number |
18590539
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Showa University |
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Principal Investigator |
GOMI Kunihide Showa University, 医学部, 教授 (60053980)
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| Co-Investigator(Kenkyū-buntansha) |
CHEN Gelin (60266111)
FUKUCHI Kunihiko (70181287)
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| Project Period (FY) |
2006 – 2010
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| Keywords | 臨床検査医学 / 院内感染 |
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| Research Abstract |
We analyzed the antibiotic resistant mechanism of bacteria responsible for nosocomial infection, such as MRSA, multidrug resistant Pseudomonas aeruginosa, ESBL producing E.coli, multidrug resistant Enterobacter cloacae. A variety of CTX-M genes or metallo-beta-lactamase genes were detected in highly resistant enterobacteriaceae. Various metallo-beta-lactamase genes were isolated from Multidrug resitant P. aeruginosa. Linezolid-resitant MRSA was isolated, and we detected the DNA mutation in rRNA region in its genome. Molecular epidemiology was performed by analyzing drug resistant gene along with genome analysis by Pulsed field gel electrophoresis.
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Research Products
(15 results)
