2007 Fiscal Year Final Research Report Summary
Exposure-effects and exposure-response relationship between indium exposure and urine indium. Availability of urine indium as biological monitoring for indium toxicty
| Project/Area Number |
18590560
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
HIRATA Miyuki Kyushu University, Faculty of medicin, Assistant Professor (30156674)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TANAKA Akiyo KYUSHU UNIVERSITY, Faculty of medicin, Assistant Professor (10136484)
OMAE Kazuyuki Keio University, Faculty of medicin, Professor (60118924)
KIYOHARA Yutaka KYUSHU UNIVERSITY, Faculty of medicin, Professor (80161602)
|
|---|
| Project Period (FY) |
2006 – 2007
|
| Keywords | indium / urine / biological monitoring / health effects / interstitial lung damage / renal toxicity / biological exposure index / dose-effect relationship |
|---|
| Research Abstract |
Objectives: To assess exposure-effect and exposure-response relationships between indium exposure and urine indium. We designed a base-line health survey of 198 indium-exposed workers.
Methods: Study subjects were 198 indium-exposed workers in 5 indium plants. Mean age of workers was 37.3. Mean indium exposure duration was 3.5 year. Urine was collected in the early morning at home because of avoidance for indium contamination at workplace. We examined serum indium(In-S), urine indium(In-U), interstitial lung injury markers; KL-6,SP-D, SP-A and renal functional biomarkers; NAG, B_2-MG, microproteinuria. Urine indium concentration was corrected by urine creatinine (ng/g Cr).
Results: Geometric mean of In-S(ng/ml) and In-U(ng/g Cr) in indium-exposed workers were 3.1, 1.4 respectively. In-U was related to indium exposure duration, In-S, KL-6 and SP-D. In-U 1ng/g Cr was corresponded to In-S 3ng/ml prescribed as biological exposure index(Japan Society for Occupational Health,2007). Prevalence(%) of NAG, B2-MG, microproteinuria exceeding the reference values were 12.6, 11.6 and 5.1.
Conclusion; Sharp relationship between serum indium and urine indium was observed. Urine indium is useful to biological monitoring as an exposure index.
|
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] インジウムによる間質性肺障害2008
Author(s)
中野真規子, 田中昭代, 平田美由紀, 道川武紘, 菊池有利子, 吉岡範幸, 佐野有里, 大前和幸
Organizer
第78回日本衛生学会
Place of Presentation
熊本
Year and Date
2008-03-29
Description
「研究成果報告書概要(和文)」より
-
[Presentation] インジウム化合物の健康障害-液晶関連電子材料物質の呼吸器影響-2007
Author(s)
平田美由紀
Organizer
第7回分子予防環境医学研究会, 日本産業衛生学会 第35回有機溶剤中毒研究会, 日本産業衛生学会第39回生物学的モニタリング・バイオマーカー研究会, 室内環境学会第1回九州支部会総会, 第9回Aldh2ノックアウトマウス学会合同大会
Place of Presentation
北九州
Year and Date
20071026-20071027
Description
「研究成果報告書概要(和文)」より
-
-
-
[Presentation] インジウムによる肺影響2007
Author(s)
中野真規子, 吉岡範幸, 菊池有利子, 佐野有里, 平田美由紀, 田中昭代, 大前和幸
Organizer
第48回日本呼吸器学会
Place of Presentation
東京千代田区
Year and Date
20070510-20070512
Description
「研究成果報告書概要(和文)」より
-
-
-
-
-
-
-
-
[Presentation] インジウム化合物粉塵作業者の呼吸器影響2006
Author(s)
岩澤聡子, 田中昭代, 平田美由紀, 菊池有利子, 西脇祐司, 吉岡範幸, 武林亨, 斉藤史武, 石坂彰敏, 佐野有里, 大前和幸
Organizer
第79回日本産業衛生学会
Place of Presentation
仙台
Year and Date
20060509-20060512
Description
「研究成果報告書概要(和文)」より
-
-
-
