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2007 Fiscal Year Final Research Report Summary

immunological effect of mineral oil in diesel exhaust

Research Project

Project/Area Number 18590562
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionUniversity of Miyazaki

Principal Investigator

KURODA Yoshiki  University of Miyazaki, Faculty of Medicine, Professor (50234620)

Co-Investigator(Kenkyū-buntansha) KUNUGITA Naoki  University of Occupational Environmental Health Japan, 産業保健学部, Associate Professor (90178020)
HIRANO Seishiro  University of Miyazaki, National Institute for Environmental Studies, Chief of group (20150162)
Project Period (FY) 2006 – 2007
KeywordsDiesel / Mineral Oil / Immunology / Exhaust / Hexadecane
Research Abstract

I have studied the influence of mineral oil for several years. And I have already studied medicinal mineral oil immunological effect. I indicated that medicinal mineral oil induced some autoantibody in mouse. But medicinal mineral oil didn't produce anti nRNP/Sm antibody and anti-Su antibody that was specific to SLE. Ingredient of medicinal mineral oil was heavier than pristine that was known as a mineral oil induced autoantibody (anti nRNP/Sm antibody and anti-Su antibody included). We considered lighter mineral oil could induce anti nRNP/Sm antibody and anti-Su antibody.
We investigated the mineral oil included in diesel exhaust. Hexadecane is typical mineral oil in diesel exhaust. So, we studied the effect of hexadecane first. And we searched for the mechanism of autoantibody induction. We indicate several new results about mineral oil below.
1,Hexadecane produced autoantibody (anti nRNP/Sm antibody and anti-Su antibody). But mice exposed diesel exhaust didn't produce autoantibody.
2,We found that the CD3ζ expression of pristane exposed mice T cell was decreased, and serum arginine was diminished too. Additionally the expression of CD3ζ was recovered with addition of arginine.
We supposed that the induction of autoantibody by mineral oil was depended on molecular weight of the oil, and was associated with reduction of CD3ζ and arginine.

  • Research Products

    (6 results)

All 2006

All Journal Article (6 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadec ane in BALB/c mice2006

    • Author(s)
      Kuroda Y
    • Journal Title

      Toxicology 218

      Pages: 186-196

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Role of non-protein amino acid L-canavanine in autoimmunity2006

    • Author(s)
      Akaogi J
    • Journal Title

      Autoimmun Rev 5

      Pages: 429-435

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane(pristane)2006

    • Author(s)
      Nacionales DC
    • Journal Title

      Am J Pathol 168

      Pages: 1227-1240

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice2006

    • Author(s)
      Kurida, Y, Ono, N, Akaogi, J, Nacionales, DC, Yamasaki, Y, Barker, TT, et. al.
    • Journal Title

      Toxicology 218

      Pages: 186-96

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Role of non-protein amino acid L-canavanine in autoimmunity2006

    • Author(s)
      Akaogi, J, Barker, T, Kuroda, Y, Nacionales, DC, Yamasaki, Y, Stevens, BR, et. al.
    • Journal Title

      Autoimmun Rev 5

      Pages: 429-35

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Type I interferon production by tertiary lymphoid tissue developing in response to 2, 6, 10, 14-tetramethyl-pentadecane(pristane)2006

    • Author(s)
      Nacionales, DC, Kelly, KM, Lee, PY, Zhuang, H, Li, Y, Weinstein, JS, et. al.
    • Journal Title

      Am J Pathol 168

      Pages: 1227-40

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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