| Co-Investigator(Kenkyū-buntansha) |
ITAI Kazuyoshi Iwate Medical University, School of Medicine, Associate Professor (10048572)
YOSHIDA Yuki Iwate Medical University, School of Medicine, Lecturer (80254762)
NAKAMURA Motoyuki Iwate Medical University, School of Medicine, Professor (40172449)
SAKATA Kiyomi Iwate Medical University, School of Medicine, Professor (50225794)
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| Research Abstract |
The Iwate-Kenpoku cohort (Iwate-KENCO) study is designed to prospectively investigate the risks of stroke and cardiovascular disease in a general population in northern area in Japan. A baseline survey was conducted as a part of a government regulated health check up for the general population. From 2002 to 2004, 26,469 participants (9,161 males and 17,308 females) took part in the program. Of these participants, 25,713 participants were measured urinary albumin. In this study, we used subject aged 40 to 74, without history of stroke. Subjects with the following characteristics were excluded; hematuria, HbA1c>6 5% and casual blood sugar>200mg/dl. The final statistical analysis was therefore performed in 6,443 males and 13,494 females. The mean follow-up period was 2 7 years, there were 54,019 person-years of observation and 183 deaths and 232 incident cases of stroke occurred during this period for men and women. Age-adjusted and multiple adjusted hazard ratios (HR) for all-cause death and incident case of stroke were calculated in each group according to A spot urine albumin to creatinine ratio (UACR) quartile by Cox proportional hazard model. In females, the multivariable-adjusted HR (95%CI)of all-cause death for Q2, Q3 and Q4 versus Q1 was 2 43 (104, 5.69), 191 (0 80, 4 56) and 2 09 (0.85, 510). The multiple adjusted HR of incident stroke in females was 0.77 (0.40, 1.50), 1.09 (0 58, 2 03), 158 (0 86, 2 87). In females, the multivariable-adjusted HR of stroke for logarithmic UACR was 124 (106, 1.47).
These results suggest the UACR is an important marker for stroke in females.
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