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2007 Fiscal Year Final Research Report Summary

Real time diagnosis of gastric mucosa and cancer using confocal endomicroscopy

Research Project

Project/Area Number 18590675
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionNagoya University

Principal Investigator

NIWA Yasumasa  Nagoya University, Graduate School of Medicine, Associate Professor (20283442)

Co-Investigator(Kenkyū-buntansha) GOTO Hidemi  Nagoya University, Graduate School of Medicine, Professor (10215501)
HIROOKA Yoshiki  Nagoya University, Nagoya University Hospital, Associate Professor (50324413)
OHMIYA Naoki  Nagoya University, Graduate School of Medicine, Associate Professor (00335035)
ANDO Takahumi  Nagoya University, Graduate School of Medicine, Associate Professor (80378041)
NAGASAKA Tetsurou  Nagoya University, Graduate School of Medicine, Associate Professor (40262894)
Project Period (FY) 2006 – 2007
Keywordsconfocal endomicroscopy / gastric cancer
Research Abstract

A confocal endomicroscopy that has recently been developed allows the observation of living cells in vivo, and some investigators have reported the usefulness of it, but no study has reported on it with regards to gastric cancer. The aim of this study was to assess the suitability of this system for use in the diagnosis of gastric cancer.
Patients and methods: Twenty-seven patients with early gastric cancer underwent confocal endomicroscopy (EG-3870CIK, Pentax, Tokyo, Japan). After intravenous administration of fluorescein sodium, confocal images obtained from fundic mucosae, pyloric mucosae and cancerous lesions were interpreted by two pathologists independently, and compared to the histological findings including CD34 immunostaining of biopsy or resected specimens of the same sites.
Results: Fluorescein yielded high-quality confocal images of gastric mucosa. Those images agreed with hematoxylin and eosin staining of transverse sections of specimens of the same sites. In the results of interpretation of two pathologists, sensitivity, specificity, and accuracy rate for the diagnosis of gastric cancer were 81.8%, 97.6%, 94.2% (pathologist A) and 90.9%, 97.6%, 96.2% (pathologist B), respectively. Accuracy rates tended to decrease if poor-image cases and unreachable cases were included.
Conclusion: Confocal endomicroscopy is useful for the diagnosis of gastric cancer. In the future, it may allow virtual biopsy and help reduce unnecessary biopsies.

  • Research Products

    (7 results)

All 2007 2006

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] 総説「共焦点内視鏡による超拡大観察」2007

    • Author(s)
      丹羽康正, 後藤秀実
    • Journal Title

      Gastroenterol Endoscopy 49

      Pages: 2677-2683

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Confocal Endomicroscopy tor the Diagnosis of GI tract2007

    • Author(s)
      Niwa Y, Goto H.
    • Journal Title

      Gastroenterol Endoscopy 49

      Pages: 2677-2683

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Confocal endomicroscopy for the diagnosis of gastric cancer in vivo.2006

    • Author(s)
      Kitabatake S, Niwa Y, Miyahara R, Ohashi A, Matuura T, Iguchi Y, Shimoyama Y, Nagasaka T, Maeda O, Ando T, Ohmiya N, Itoh A, Hirooka Y, Goto H.
    • Journal Title

      Endoscopy 38

      Pages: 1110-4

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Presentation] 共焦点内視鏡を用いた消化管疾患の診断-エンドサイトスコープとの比較2007

    • Author(s)
      丹羽康正, 宮原良二, 後藤秀実
    • Organizer
      第73回日本消化器内視鏡学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Diagnosis of GI tract lesions using confocal endomicroscopy compared with endocytescopy2007

    • Author(s)
      Niwa Y, Miyahara R, Goto H.
    • Organizer
      The 73rd Congress of the Japan Gastro enterological Endoscopy Society.
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-05-09
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 共焦点内視鏡を用いた画像解析の試み2006

    • Author(s)
      北畠秀介, 丹羽康正, 他
    • Organizer
      第71回日本消化器内視鏡学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] The image analysis of GI tract lesions using confocal endomicroscopy.2006

    • Author(s)
      Kitabatake S, Niwa Y, et al.
    • Organizer
      The 71st Congress of the Japan Gastroenterological Endosconv Society
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-05-15
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-06-09  

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