Role of arachidonic acid in development of Barrett's esophagus and cancer

2008 Fiscal Year Final Research Report

• Project/Area Number: 18590696
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka City University
• Principal Investigator: FUJIWARA Yasuhiro Osaka City University, 大学院・医学研究科, 准教授 (40285292)
• Co-Investigator(Kenkyū-buntansha): WATANABE Toshio 大阪市立大学, 大学院・医学研究科, 講師 (50336773) ; TOMINAGA Kazunari 大阪市立大学, 大学院・医学研究科, 講師 (80336768)
• Co-Investigator(Renkei-kenkyūsha): HIGUCHI Kazuhide 大阪医科大学, 医学部, 教授 (20218697)
• Project Period (FY): 2006 – 2008
• Keywords: バレット食道 / 食道腺癌 / プロスタグランジン

Research Abstract

BNラットの空腸食道吻合により、バレット食道・食道腺癌が発生した。食道粘膜炎症部ではPGE2が増加しており、COX-2およびmPGES-1、EP4受容体の発現が増強していた。また酸逆流により喘息ラットにおける好酸球を主体とした気道炎症増強およびTh2系サイトカイン発現増加が確認された。一方、正常ヒト食道扁平上皮細胞に混合胆汁酸を曝露させることで、腸上皮化生のマーカーであるCdX2誘導が惹起された

Research Products

• [Journal Article] Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis (2009)
  • Author(s): Otani K, Watanabe T, Tanigawa T, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T.
  • Journal Title: Biochem Biophys Res Commun 382(2) Pages: 252-8
  • Peer Reviewed
• [Journal Article] A novel rat model to determine interaction between reflux oesophagitis and bronchial asthma (2008)
  • Author(s): Sugawa T, Fujiwara Y, Yamagami H, Watanabe K, Tanigawa T, Shiba M, Watanabe T, Tominaga K, Oshitani N, Higuchi K, Arakawa T.
  • Journal Title: Gut 57(5) Pages: 575-81
  • Peer Reviewed
• [Journal Article] Interleukin-10 gene transfer to peritoneal mesothelial cells suppresses peritoneal dissemination of gastric cancer cells due to a persistently high concentration in the peritoneal cavity (2008)
  • Author(s): Tanaka F, Tominaga K, Shiota M, Ochi M, Kuwamura H, Tanigawa T, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Iwao H, Arakawa T.
  • Journal Title: Cancer Gene Ther 15(1) Pages: 51-9
  • Peer Reviewed
• [Journal Article] Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats (2008)
  • Author(s): Tanaka F, Tominaga K, Ochi M, Tanigawa T, Watanabe T, Fujiwara Y, Ohta K, Oshitani N, Higuchi K, Arakawa T.
  • Journal Title: Life Sci. 83(23-24) Pages: 771-9
  • Peer Reviewed
• [Journal Article] Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent (2008)
  • Author(s): Watanabe T, Higuchi K, Kobata A, Nishio H, Tanigawa T, Shiba M, Tominaga K, Fujiwara Y, Oshitani N, Asahara T, Nomoto K, Takeuchi K, Arakawa T.
  • Journal Title: Gut 57(2) Pages: 181-7
  • Peer Reviewed
• [Journal Article] Growth inhibition of colon cancer cells by transfection of dominant-negative apoptosis signal-regulating kinase-1 (2007)
  • Author(s): Kuwamura H, Tominaga K, Shiota M, Ashida R, Nakao T, Sasaki E, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Ichijo H, Arakawa T, Iwao H.
  • Journal Title: Oncol Rep 17(4) Pages: 781-6
  • Peer Reviewed
• [Journal Article] Roles of ZO-1 and epidermal growth factor in esophageal epithelial defense against acid (2007)
  • Author(s): Okuyama M, Fujiwara Y, Tanigawa T, Watanabe K, Shiba M, Tominaga K, Watanabe T, Oshitani N, Higuchi K, Arakawa T.
  • Journal Title: Digestion 75(2-3) Pages: 135-41
  • Peer Reviewed
• [Journal Article] Synergistic antitumor effect of combined 5-fluorouracil (5-FU) with 5-chloro-2, 4-dihydroxypyridine on 5-FU-resistant gastric cancer cells : possible role of a dihydropyrimidine dehydrogenase-independent mechanism (2007)
  • Author(s): Sasaki E, Tominaga K, Kuwamura H, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T.
  • Journal Title: J Gastroenterol 42(10) Pages: 816-22
  • Peer Reviewed
• [Journal Article] Roles of cyclooxygenase 2 and microsomal prostaglandin E synthase 1 in rat acid reflux oesophagitis (2006)
  • Author(s): Hayakawa T, Fujiwara Y, Hamaguchi M, Sugawa T, Okuyama M, Sasaki E, Watanabe T, Tominaga K, Oshitani N, Higuchi K, Arakawa T.
  • Journal Title: Gut 55(4) Pages: 450-6
  • Peer Reviewed
• [Journal Article] Roles of epidermal growth factor and Na+/H+ exchanger-1 in esophageal epithelial defense against acid-induced injury (2006)
  • Author(s): Fujiwara Y, Higuchi K, Takashima T, Hamaguchi M, Hayakawa T, Tominaga K, Watanabe T, Oshitani N, Shimada Y, Arakawa T.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol 290(4) Pages: G665-73
  • Peer Reviewed
• [Presentation] GERDと喘息の相互関連についての基礎的検討 (2008)
  • Author(s): 藤原靖弘、須川貴史、谷川徹也、渡辺俊雄、富永和作、荒川哲男
  • Organizer: 第36回日本潰瘍学会
  • Place of Presentation: 札幌
  • Year and Date: 2008-09-05
• [Presentation] Sleep disturbance in Japanese GERD patients (2007)
  • Author(s): Fujiwara Y.
  • Organizer: アジア太平洋消化器病学会
  • Place of Presentation: 神戸
  • Year and Date: 2007-10-18
• [Presentation] A novel rat model to determine the pathogenic association between reflux esophagitis and bronchial asthma (2007)
  • Author(s): Sugawa T, Fujwiara Y, Okuyama M, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Oshitani N, Higuchi K, Arakawa T.
  • Organizer: 米国消化器病学会
  • Place of Presentation: WA, USA
  • Year and Date: 2007-05-19
• [Presentation] Barrett's esophagus Cancer prevention wih anti-inflammatory aspects (2007)
  • Author(s): Fujiwara Y.
  • Organizer: International Symposium on Cancer Prevention
  • Place of Presentation: 韓国
  • Year and Date: 2007-02-23
• [Presentation] Clinical characteristic and treatment of non-erosive reflux disease in Japan (2007)
  • Author(s): Fujiwara Y.
  • Organizer: 日本消化管学会国際シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-02-02
• [Presentation] Role of aracidonic acid metabolism in rat acid reflux esophagitis (2006)
  • Author(s): Hayakawa T, Fujiwara Y, Hamaguchi M, Sugawa T, Okuyama M, Sasaki E, Watanabe T, Tominaga K, Oshitani N, Higuchi K, Arakawa T.
  • Organizer: 米国消化器病学会
  • Place of Presentation: LA, CA, USA
  • Year and Date: 2006-05-21