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2007 Fiscal Year Final Research Report Summary

Investigative of diffentiation of pancreatic cells and application for treatments for chronic pancreatitis

Research Project

Project/Area Number 18590750
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionTokai University

Principal Investigator

MINE Tetsuya  Tokai University, School of Medicine, Professor (20157572)

Co-Investigator(Kenkyū-buntansha) HABU Sonoko  Tokai University, School of Medicine, Professor (30051618)
HOZUMI Katsuto  Tokai University, School of Medicine, Associate Professor (30246079)
Project Period (FY) 2006 – 2007
KeywordsNoctch / Transgenicmouse / D111 / Jagged / exocrine / endocrine / knockout mouse / Ptfla-Cre
Research Abstract

Appearance of Jagged1 was confirmed in pancreatic tissue at E15. 5 Pancreas-specific Jaggedl-floxed knock-out mice were made.
In pancreas-specific. jaggedl floxed knock-out mice, the cells in which function of amylase secretion was made and secretion of insulin and glucagon were demonstrated. In part, exocrine tissues were changed to fatty tissues

  • Research Products

    (10 results)

All 2007

All Journal Article (10 results) (of which Peer Reviewed: 5 results)

  • [Journal Article] Comparison of the effectiveness of geranylgeranylacetone with cimetidine in gastritis patients with dyspeptic symptoms and gastric lesions2007

    • Author(s)
      Sakamoto C
    • Journal Title

      Digestion 75

      Pages: 215-24

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Clinical and pathological features of a prolonged type of acute intrahepatic cholestasis2007

    • Author(s)
      Watanabe N
    • Journal Title

      Hepatol Res 37

      Pages: 598-607

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Clinical utility of double-balloon enteroscopy for small intestinal bleeding2007

    • Author(s)
      Suzuki T
    • Journal Title

      Dig Dis Sci. 52

      Pages: 1914-8

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] A liver-derived immunosuppressive factor is an arginase:identification and mechanism of immunosuppression2007

    • Author(s)
      Ohtani Y
    • Journal Title

      Biomed Res 28

      Pages: 17-23

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells2007

    • Author(s)
      Mochizuki K
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 292

      Pages: 818-28

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Comparison of the effectiveness of geranylgeranylacetone with cimetidine in gastritis patients with dyspeptic symptoms and gastric lesions2007

    • Author(s)
      Sakamoto, C
    • Journal Title

      Digestion 75(4)

      Pages: 215-24

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Clinical and pathological features of a prolonged type of acute intrahepatic cholestasis2007

    • Author(s)
      Watanabe, N
    • Journal Title

      Hepatol Res 37

      Pages: 598-607

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Clinical utility of double-balloon enteroscopy for small intestinal bleeding2007

    • Author(s)
      Suzuki, T
    • Journal Title

      Dig Dis Sci 52(8)

      Pages: 1914-8

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A liver-derived immunosuppressive factor is an arginase : identification and mechanism of immunosuppression2007

    • Author(s)
      Ohtani, Y
    • Journal Title

      Biomed Res 28(1)

      Pages: 17-23

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Two N-linked glycans are required to maintain the transport activity of the bile salt export pump(ABCB11) in MDCK II cells2007

    • Author(s)
      Mochizuki, K
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 292(3)

      Pages: G818-28

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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