2007 Fiscal Year Final Research Report Summary
Investigative of diffentiation of pancreatic cells and application for treatments for chronic pancreatitis
| Project/Area Number |
18590750
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokai University |
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Principal Investigator |
MINE Tetsuya Tokai University, School of Medicine, Professor (20157572)
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| Co-Investigator(Kenkyū-buntansha) |
HABU Sonoko Tokai University, School of Medicine, Professor (30051618)
HOZUMI Katsuto Tokai University, School of Medicine, Associate Professor (30246079)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Noctch / Transgenicmouse / D111 / Jagged / exocrine / endocrine / knockout mouse / Ptfla-Cre |
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| Research Abstract |
Appearance of Jagged1 was confirmed in pancreatic tissue at E15. 5 Pancreas-specific Jaggedl-floxed knock-out mice were made.
In pancreas-specific. jaggedl floxed knock-out mice, the cells in which function of amylase secretion was made and secretion of insulin and glucagon were demonstrated. In part, exocrine tissues were changed to fatty tissues
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