2009 Fiscal Year Final Research Report
Novel mechanisms of pancreatic fibrosis and epithelial to mesenchymal transition in pancreatic diseases.
| Project/Area Number |
18590752
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
SHIMIZU Kyoko Tokyo Women's Medical University, 医学部, 准教授 (90187451)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 膵臓病学 |
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| Research Abstract |
Pancreatic stellate cells (PSCs) play a pivotal role in pancreatic fibrogenesis in chronic pancreatitis and in the desmoplastic reaction in pancreatic cancer. We demonstrated that PSCs are associated with phagocytosis and innate immunity via toll-like receptors, but not with acquired immunity via MHC class II. PSCs that engulfed dead cells inhibited proliferation, invasion, and chemotaxis by pancreatic cancer cells in a manner that was mediated by luminal factors released by PSCs, suggesting that the phagocytic function of PSCs modulates the epithelial-mesenchymal transition in pancreatic cancer.
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