2007 Fiscal Year Final Research Report Summary
A Critical Role of Inflammation in the Progression of Cardiovascular Remodeling
| Project/Area Number |
18590762
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SUZUKI Jun-ichi Tokyo Medical and Dental University, Department of Cardiovascular Medicine, Assistant Professor (90313858)
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| Co-Investigator(Kenkyū-buntansha) |
INAGAKI Hiroshi Tokyo Medical and Dental University, Department of Cardiovascular Medicine, Junior Lecturer (60376803)
SAKURAI Kaoru National Disaster Medical Center, Department of Cardiovascular Medicine, Medical Doctor (70376771)
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| Project Period (FY) |
2006 – 2007
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| Keywords | inflammation / cardiac transplantation / myocarditis / myocardial ischemia / arteriosclerosis / gene transfer / animal models / clinical trial |
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| Research Abstract |
Background. Inflammation is a central event in cardiovascular diseases such as myocardial infarction, myocarditis, transplant rejection and arteriosclerosis after angioplasty. Methods and Results. To evaluate the effectiveness of blocking inflammation to prevent these diseases, we made several murine and rat experimental models. We showed that each treatment using a clarithromycin, pitavastatin, pioglitazone, or tea catechins prevented acute and chronic cardiac rejection. We also demonstrated that treatment with tea catechins, a CCR1 antagonist, or a COX-2 inhibitor suppressed the rat autoimmune myocarditis. A specific I-kB inhibitor or tea catechins significantly suppressed ventricular remodeling after myocardial ischemia. An NF-kB decoy suppressed arterial neointimal formation after arterial injury in a murine model. Based on these results, we performed clinical trials to prevent restenosis after PCI. Conclusion. Inflammation plays a pivotal role in cardiovascular diseases. These results suggest the clinical usefulness of gene therapies to regulate inflammatory cardiovascular diseases.
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[Journal Article] Utility of gallium-67 scintigraphy for evaluation of cardiac sarcoidosis with ventricular tachycardia.2006
Author(s)
Futamatsu H, Suzuki J, Adachi S, Okada H, Otomo K, Ohara T, Hashimoto Y, Kakuta T, lesaka Y, Yamaguchi H, Sakurada H, Sato A, Obayashi T, Niwa A, Hirao K, Isobe M
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Journal Title
Int J Cardiouas Imag 113
Pages: 2613-2622
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] A new RXR agonist, HX630, suppresses intimal hyperplasia in amouse blood flow cessation model.2006
Author(s)
Haraguchi G, Suzuki J, Kosuge H, Ogawa M, Koga N, Muto S, Itai A, Kagechika H, Shudo K, Isobe M
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Journal Title
J Mol Cell Cardiol 41
Pages: 885-892
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Utility of gallium-67 scintigraphy for evaluation of cardiac sarcoidosis with ventricular tachycardia2006
Author(s)
Futamatsu H, Suzuki J, Adachi S, Okada H, Otomo K, Ohara T, Hashimoto Y, Kakuta T, Iesaka Y, Yamaguchi H, Sakurada H, Sato A, Obayashi T, Niwa A, Hirao K, Isobe M.
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Journal Title
Int J Cardiovas Imag 22
Pages: 443-448
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model2006
Author(s)
Haraguchi G, Suzuki J, Kosuge H, Ogawa M, Koga N, Muto S, Itai A, Kagechika H, Shudo K, Isobe M.
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Journal Title
J Mol Cell Cardiol 41
Pages: 885-892
Description
「研究成果報告書概要(欧文)」より
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