2007 Fiscal Year Final Research Report Summary
Study for the mechanism of mechanical alternans
| Project/Area Number |
18590763
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
KODAMA Makoto Niigata University, Institute of Medicine and Dentistry, Associate Professor (10242447)
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| Co-Investigator(Kenkyū-buntansha) |
HANAWA Haruo Niigata University, Institute of Medicine and Dentistry, Lecturer (40282983)
OKURA Yuji Niigata University, Institute of Meduane and Dentistry, Assistant Professor (90361914)
HIRONO Satoru Niigata University, Institute of Medicine and Dentistry, Assistant Professor (40401765)
ITO Masahiro Niigata University, Medical and Dental Hospital, Specially Appointed Assistant Professor (90397109)
KASHIMURA Takeshi Niigata University, Medical and Dental Hospital, Post doctoral fellow (70419290)
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| Project Period (FY) |
2006 – 2007
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| Keywords | mechanical alternans / electrical alternans / heart failure / sudden death / force-frequency relationship / interval-force relationship / pressure-volume curve |
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| Research Abstract |
Mechanical alternans is a poorly-understood phenomenon of alternating strong and weak beats with a constant beat-to-beat interval. It is a possible linker between failing myocardium and ventricular fibrillation in patients with chronic heart failure. Interval-force relationship, so-called mechanical restitution, is an intrinsic regulatory principle of myocardial contractility depending on sarcoplasmic reticulum (SR)Ca^(2+) cycling. Force-frequency relationship is also considered to reflect Ca^(++) handling of SR. We analyzed interval-force relationship and force frequency relationship in patients with chronic heart failure. In patients with atrial fibrillation, mechanical restitution curves were able to be obtained from beat by beat variance of left ventricular contractility adjusted by pre-preceding coupling intervals. We estimated mechanical restitution curves by fitting to monoexponential curves. Tau of the mechanical restitution curve increased in accord with the decrease of ejection fraction. We analyzed force-frequency relationship. In patients with chronic heart failure, peak force rate shifted to lower heart rate. The force gain of patients was little. A force gain was correlated to the left ventricular ejection fraction. We were able to obtain adequate mechanical restitution curves after both strong beats and weak beats from some patients. Mechanical restitution curves after weak beats steeply rose compared with those after strong beats. The time constant after weak beats were shorter than those after strong beats. Thus mechanical restitution properties were different after strong beats and weak beats during mechanical alternans. This implies that mechanical alternans originates from alternating changes of myocardial Ca^(2+) cycling property.
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Research Products
(22 results)
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[Journal Article] Angiopoietin-1, Angiopoietin-2 and Tie-2 in the Coronary Circulation of Patients with and without Coronary Collateral Vessels2007
Author(s)
Wataru, Mitsuma, Makoto, Kodama, Satoru, Hirono, Masahiro, Ito, Mahmoud, M., Ramadan, Komei, Tanaka, Makoto, Hoyano, Takashi, Saigawa, Takeshi, Kashimura, Koichi, Fuse, Yuji, Okura, Yoshifusa, Aizawa
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Serum Endostatin in the Coronary Circulation of Patients with Coronary Heart Disease and Its Relation to Coronary Collateral Formation2007
Author(s)
Wataru, Mitsuma, Makoto, Kodama, Haruo, Hanawa, Masahiro, Ito, Mahmoud, M, Ramadan, Satoru, Hirono, Hiroaki, Obata, Shinsuke, Okada, Fumihiro, Sanada, Takao, Yanagawa, Takeshi, Kashimura, Koichi, Fuse, Naohito, Tanabe, Yoshifusa, Aizawa
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Journal Title
Am J Cardiol 99
Pages: 494-498
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Swimming stress in DN14-3-3 mice triggers maladaptive cardiac remodeling. Role of p38 MAPK2007
Author(s)
Kenichi, Watanabe, Meilei, Ma, Kenichi, Hirabayashi, Narasimman, Gurusamy, Punniyakoti, T, Veeraveedu, Paras, Prakash, Shaosong, Zhang, Anthony, J, Muslin, Makoto, Kodama, Yoshifusa, Aizawa
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Journal Title
Am J Physiol Heart Circ Physiol 292
Pages: 1267-1277
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Serial Electrocardiographic Findings in Women with Takotsubo Cardiomyopathy2007
Author(s)
Mitsuma, W, Kodama, M, Ito, M, Tanaka, K, Yanagawa, T, Ikarashi, N, Sugiura, K, Kimura, S, Yagihara, N, Kashimura, T, Fuse, K, Hirono, S, Okura, Y, Aizawa, Y
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Journal Title
Am J Cardiol 2007 100
Pages: 106-109
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Angiopoietin-1, Angiopoietin-2, and Tie-2 in the Coronary Circulation of Patients with and without Coronary Collateral Vessels2007
Author(s)
Wataru, Mitsuma, Makoto, Kodama, Satoru, Hirono, Masahiro, Ito, Mahmoud, M. Ramadan, Komei, Tanaka, Makoto, Hoyano, Takeshi, Kashimura, Koichi, Fuse, Yuji, Okura, Yoshifusa, Aizawa
Organizer
The 71st Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Kobe
Year and Date
20070315-17
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Mechanical alternans is a possible linker between heart failure and ventricular fibrillation2007
Author(s)
Makoto, Kodama, Takeshi, Kashimura, Masahiro, Ito, Koichi, Fuse, Wataru, Mitsuma, Satoru, Hirono, Yuji, Okura, Kiminori, Kato, Haruo, Hanawa, Yoshifusa, Aizawa
Organizer
The 71st Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Kobe
Year and Date
20070315-17
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Serum endostatin in the coronary circulation of patients with coronary heart disease and its relation to coronary collateral formation2007
Author(s)
Wataru, Mistuma, Makoto, Kodama, Haruo, Hanawa, Masahiro, Ito, Mahmoud, M, Ramadan, Komei, Tanaka, Takeshi, Kashimura
Organizer
The 71st Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Kobe
Year and Date
20070315-17
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Immunoglobulin therapy for myocarditis2006
Author(s)
Makoto, Kodama, Daisuke, Izumi, Haruo, Hanawa, Yoshifusa, Aizawa
Organizer
International Academy of Cardiovascular Science. The 2nd World Congress
Place of Presentation
Sapporo
Year and Date
20060714-16
Description
「研究成果報告書概要(欧文)」より
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