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2009 Fiscal Year Final Research Report

Myocardial regeneration by redox regulation in myocarditis with heart failure

Research Project

  • PDF
Project/Area Number 18590772
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKyoto University

Principal Investigator

KISHIMOTO Chiharu  Kyoto University, 医学研究科, 助教 (70169845)

Project Period (FY) 2006 – 2009
Keywordsレドックス / 心不全 / 心筋再生療法 / 酸化ストレス / チオレドキシン
Research Abstract

We investigated the role of myocardial redox system using animal model of myocardial dysfunction. As a result, the important role for myocardial regeneration of redox system was clarified.

  • Research Products

    (69 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (24 results) (of which Peer Reviewed: 23 results) Presentation (42 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Antioxidants reduce the severity of atherosclerosis2010

    • Author(s)
      Kishimoto C, Shimada K
    • Journal Title

      Website of International Atherosclerosis Society, Jan. 8

    • Peer Reviewed
  • [Journal Article] N-acetylcysteine reduces the severity of atherosclerosis in apolipoprotein E deficient mice via reducing superoxide production2009

    • Author(s)
      Shimada K, Murayama T, Yokode M, Kita T, Uzui H, Ueda T, Lee JD, Kishimoto C
    • Journal Title

      Circ J 73

      Pages: 1337-1341

    • Peer Reviewed
  • [Journal Article] QRS voltages are transiently increased at the superacute stage of experimental myocarditis2008

    • Author(s)
      Kishimoto C, Ohmae M, Tomioka N
    • Journal Title

      Exp Clin Cardiol 13

      Pages: 15-18

    • Peer Reviewed
  • [Journal Article] Naloxone, an opiate receptor antagonist, ameliorates acute experimental autoimmune myocarditis by reducing cytotoxic activities2008

    • Author(s)
      Kishimoto C, Okabe T, Hattori M, Yuan Z
    • Journal Title

      J Cardiovasc Pharmacol 52

      Pages: 445-451

    • Peer Reviewed
  • [Journal Article] L-arginine ameliorates experimental autoimmune myocarditis by maintaining extracellular matrix and reducing cytotoxic activity of lymphocytes2008

    • Author(s)
      Okabe T, Hattori M, Yuan Z, Kishimoto C
    • Journal Title

      Int J Exp Path 89

      Pages: 382-388

    • Peer Reviewed
  • [Journal Article] PPAR gamma gene C161T substitution is associated with reduced risk of coronary artery disease and decreased proinflammatory cytokine expression2007

    • Author(s)
      Liu Y, Yuan Z, Liu Y, Zhang J, Yin P, Wang D, Wang Y, Kishimoto C, Ma A
    • Journal Title

      Am Heart J 154

      Pages: 718-724

    • Peer Reviewed
  • [Journal Article] Exercise training reduces severity of atherosclerosis in apolipoprotein E knockout mice via nitric oxide2007

    • Author(s)
      Shimada K, Kishimoto C, Okabe T, Hattori M, Murayama T, Yokode M, Kita T
    • Journal Title

      Circ J 71

      Pages: 1147-1151

    • Peer Reviewed
  • [Journal Article] Swimming reduces the severity of atherosclerosis in apolipoprotein E deficient mice by antioxidant effects2007

    • Author(s)
      Okabe T, Shimada K, Hattori M, Murayama T, Yokode M, Kita T, Kishimoto C
    • Journal Title

      Cardiovasc Res 74

      Pages: 537-545

    • Peer Reviewed
  • [Journal Article] Immunoglobulin therapy, myocardial diseases and atherosclerosis: Recent experimental and clinical studies2007

    • Author(s)
      Kishimoto C
    • Journal Title

      Curr Cardiol Rev 3

      Pages: 15-21

    • Peer Reviewed
  • [Journal Article] NG-nitro-L-arginine methyl ester (L-NAME)の投与は運動による動脈硬化抑制効果を阻害する2007

    • Author(s)
      島田佳奈, 岸本千晴, 岡部孝明, 村山敏典, 横出正之, 北徹
    • Journal Title

      呼吸と循環 55

      Pages: 1-5

    • Peer Reviewed
  • [Journal Article] Effects of exercise on the development of atherosclerosis in apolipoprotein E-deficient mice2006

    • Author(s)
      Okabe T, Kishimoto C, Murayama T, Yokode M, Kita T
    • Journal Title

      ExpClin Cardiol 11

      Pages: 276-279

    • Peer Reviewed
  • [Journal Article] Effects of MCI-186 (edaravone), a novel free radical scavenger, upon experimental atherosclerosis in apolipoprotein E-deficient mice2006

    • Author(s)
      Okabe T, Kishimoto C, Shimada K, Murayama T, Yokode M, Kita T
    • Journal Title

      Circ J 70

      Pages: 1216-1219

    • Peer Reviewed
  • [Journal Article] Revelance of inflammatory cells infiltrates for complete AV-block in experimental murine myocarditis2006

    • Author(s)
      Kishimoto C, Ohmae M, Tomioka N
    • Journal Title

      Cardiovasc Pathol 15

      Pages: 139-143

    • Peer Reviewed
  • [Journal Article] Carotid intima-media thickness is increased in subjects with ischemic heart disease having a familial incidence2006

    • Author(s)
      Kishimoto C, Hirata M, Hama K, Tanaka M, Nishimura K, Kubo S, Veda K, Fujioka T, Tamaki S
    • Journal Title

      Exp & Clin Cardiol 11

      Pages: 8-10

    • Peer Reviewed
  • [Journal Article] A novel approach to the suppression of atherosclerosis by Fcγreceptor blockade2006

    • Author(s)
      Kishimoto C
    • Journal Title

      Circ Res 99

      Pages: 1154-1155

    • Peer Reviewed
  • [Journal Article] FcγIIB and cardiovascular inflammatory disease2006

    • Author(s)
      Kishimoto C, Shioji K, Yuan Z
    • Journal Title

      Circ Res 98

      Pages: e26

    • Peer Reviewed
  • [Journal Article] 免疫グロブリンはFc部分を介して実験的動脈炎・硬化病変を改善する2006

    • Author(s)
      二又正臣, 岸本千晴, 袁祖貽, 塩路圭介, 北徹, 佐野秀人, 許揚, 横出正之
    • Journal Title

      Trend of IVIg (3)

      Pages: 11

    • Peer Reviewed
  • [Journal Article] 心房細・粗動を有する陳旧性心筋梗塞患者のジピリダモール負荷心筋シンチグラフィー時にみられた規則的R-Rについて2006

    • Author(s)
      岸本千晴, 吉田由紀, 全栄和, 中村玲雄, 伊藤一貴
    • Journal Title

      J Cardiol 48

      Pages: 285-288

    • Peer Reviewed
  • [Journal Article] Immunoglobulin stabilizes plaque formation in experimental atherosclerosis2006

    • Author(s)
      Shimada K, Kishimoto C, Okabe T, Murayama T, Yokode M, Kita T
    • Journal Title

      J Cardiol 47

      Pages: 293-297

    • Peer Reviewed
  • [Journal Article] アポリポプロテインEノックアウトマウスにおける後期免疫グロブリン治療は脂肪プラークを安定させ動脈効果を抑制する2006

    • Author(s)
      島田佳奈, 岸本千晴, 岡部孝明, 村山敏典, 横出正之, 北徹
    • Journal Title

      呼吸と循環 54

      Pages: 663-667

    • Peer Reviewed
  • [Journal Article] Therapy with granulocyte colony-stimulating factor in the chronic stage, but not in the acute stage, improves experimental autoimmune myocarditis in rats via nitric oxide

    • Author(s)
      Shimada K, Okabe T, Mikami Y, Hattori M, Fujita M, Kishimoto C
    • Journal Title

      J Moll Cell Cardiol (in press)

    • Peer Reviewed
  • [Journal Article] Olmesartan, a novel angiotensin II type 1 receptor antagonist, reduces severity of atherosclerosis in apolipoprotein E deficient mice associated with reducing superoxide production

    • Author(s)
      Shimada K, Murayama T, Yokode M, Kita T, Fujita M, Kishimoto C
    • Journal Title

      Nutrition, Metabolism & Cardiovascular Disease (in press)

    • Peer Reviewed
  • [Journal Article] High glucose promotes intracellular lipid accumulation in vascular smooth muscle cells by impairing cholesterol influx and efflux balance

    • Author(s)
      Xue JH, Yuan Z, Wu Y, Liu Y, Zhao Y, Zhang WP, Tian YL, Liu WM, Liu Y, Kishimoto C
    • Journal Title

      Cardiovasc Res (in press)

    • Peer Reviewed
  • [Journal Article] Pioglitazone modulates the balance of effector and regulatory T cells in apolipoprotein Edeficient mice

    • Author(s)
      Tian Y, Yuan Z, Liu Y, Liu W, Zhang W, Xue J, Shen Y, Liang X, Chen T, Kishimoto C
    • Journal Title

      Nutrition, Metabolism & Cardiovascular Disease (in press)

  • [Presentation] Activation of Cannabinoid-2 receptor ameliorates atherosclerosis associated with suppression of proinflammatory responses2010

    • Author(s)
      Kishimoto C
    • Organizer
      第74回日本循環器学会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      20100305-20100307
  • [Presentation] Inhibitory Fcγreceptor protects against the development of myocarditis in mice2010

    • Author(s)
      Kishimoto C
    • Organizer
      第74回日本循環器学会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      20100305-20100307
  • [Presentation] Erythromycin treatment suppressed myocardial injury in autoimmune myocarditis2010

    • Author(s)
      Shimada K
    • Organizer
      第74回日本循環器学会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      20100305-20100307
  • [Presentation] 自己免疫性心筋炎に対するErythromycinの効果2009

    • Author(s)
      島田佳奈
    • Organizer
      第31回心筋生検研究会
    • Place of Presentation
      大阪
    • Year and Date
      20091127-20091128
  • [Presentation] Temocapril treatment ameliorates autoimmune myocarditis associated with enhanced cardiomyocyte thioredoxin expression2009

    • Author(s)
      Kishimoto C, Yuan Z, Shioji K, Nakamura H, Yodoi J
    • Organizer
      The American Heart Association's Scientific Sessions 2009
    • Place of Presentation
      Orlando
    • Year and Date
      20091114-20091118
  • [Presentation] Olmesartan, an angiotensin II receptor type 1 antagonist, suppresses cytotoxic myocardial injury in autoimmune heart failure2009

    • Author(s)
      Kishimoto C, Nimata M, Okabe T, Shioji K, Yuan Z
    • Organizer
      The American Heart Association's Scientific Sessions 2009
    • Place of Presentation
      Orlando
    • Year and Date
      20091114-20091118
  • [Presentation] テモカプリルは抗酸化効果により心筋炎・心不全を改善する2009

    • Author(s)
      岸本千晴
    • Organizer
      第57回日本心臓病学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      20090918-20090920
  • [Presentation] NO前駆物質L-アルギニンは心筋炎・心不全を改善する2009

    • Author(s)
      岸本千晴
    • Organizer
      第57回日本心臓病学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      20090918-20090920
  • [Presentation] 心筋炎発症の超急性期にはQRS電位は増加する2009

    • Author(s)
      岸本千晴
    • Organizer
      第57回日本心臓病学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      20090918-20090920
  • [Presentation] 発症直後にNK-T細胞の著明な低下を示した心筋炎の一例2009

    • Author(s)
      岸本千晴
    • Organizer
      第57回日本心臓病学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      20090918-20090920
  • [Presentation] Pioglitazone ameliorates atherosclerosis in apolipoprotein E deficient mice by modulating the balance of effector and regulatory T cells2009

    • Author(s)
      Kishimoto C
    • Organizer
      第73回日本循環器学会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20090320-20090322
  • [Presentation] Induction of vulnerable plaques by marble-burying behavior and their stabilization by exercise training in experimental atherosclerosis2009

    • Author(s)
      Shimada K
    • Organizer
      第73回日本循環器学会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20090320-20090322
  • [Presentation] Naloxone, an opiate receptor antagonist, ameliorates acute heart failure in experimental autoimmune myocarditis by reducing cytotoxic activities2009

    • Author(s)
      Kishimoto C
    • Organizer
      第73回日本循環器学会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20090320-20090322
  • [Presentation] Immunoglobulin treatment ameliorates murine myocarditis associated with reduction of neurohumoral activity and improvement of extracellular matrix change2009

    • Author(s)
      Kishimoto C
    • Organizer
      第73回日本循環器学会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20090320-20090322
  • [Presentation] 家族歴を有する虚血性心疾患患者における頸動脈内膜中膜肥厚の重要性2008

    • Author(s)
      岸本千晴
    • Organizer
      第56回日本心臓病学会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      20080908-20080910
  • [Presentation] カルベジロールはβ-遮断効果というよりも抗酸化効果によって自己免疫性心筋炎を改善する2008

    • Author(s)
      岸本千晴
    • Organizer
      第56回日本心臓病学会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      20080908-20080910
  • [Presentation] Immunoglobulin treatment suppresses oxidative stress-mediated myocardial injury2008

    • Author(s)
      Kishimoto C
    • Organizer
      第72回日本循環器学会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      20080328-20080330
  • [Presentation] Post-myocarditic G-CSF therapy improves the severity of the disease in experimental autoimmune myocarditis in rats2008

    • Author(s)
      Kishimoto C
    • Organizer
      第72回日本循環器学会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      20080328-20080330
  • [Presentation] Therapy with immunoglobulin prevents acute death in patients with fulminant myocarditis2008

    • Author(s)
      Kishimoto C
    • Organizer
      第72回日本循環器学会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      20080328-20080330
  • [Presentation] Swimming reduces the severity of atherosclerosis in apolipoprotein E deficient mice by antioxidant effects2008

    • Author(s)
      Kishimoto C
    • Organizer
      第72回日本循環器学会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      20080328-20080330
  • [Presentation] マウスの動脈硬化に対するガラス玉覆い隠し行動と運動の影響2008

    • Author(s)
      島田佳奈
    • Organizer
      第106回日本循環器学会・近畿地方会
    • Place of Presentation
      神戸
    • Year and Date
      2008-11-29
  • [Presentation] 下肢咬創による長期の安静臥床により症状が悪化した心不全の一例2008

    • Author(s)
      岸本千晴
    • Organizer
      第106回日本循環器学会・近畿地方会
    • Place of Presentation
      神戸
    • Year and Date
      2008-11-29
  • [Presentation] 炎症性心臓・血管病に対する治療戦略2008

    • Author(s)
      岸本千晴
    • Organizer
      藤枝市立総合病院主催・学術講演会
    • Place of Presentation
      静岡県
    • Year and Date
      2008-09-26
  • [Presentation] 実験的自己免疫性心筋炎に対するG-CSFの効果2007

    • Author(s)
      島田佳奈, 三神優, 岡部孝明, 藤田正俊, 岸本千晴
    • Organizer
      第29回心筋生検研究会
    • Place of Presentation
      名古屋
    • Year and Date
      20071130-20071201
  • [Presentation] PPAR-γリガンドは自己免疫性心筋炎を改善する2007

    • Author(s)
      岸本千晴, 袁祖胎, 塩路圭介, 北徹
    • Organizer
      第55回日本心臓学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      20070910-20070912
  • [Presentation] 新規AT1拮抗剤オルメサルタンは自己免疫性心筋炎を改善する2007

    • Author(s)
      岸本千晴, 岡部孝明, 塩路圭介, 島田佳奈, 北徹
    • Organizer
      第55回日本心臓学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      20070910-20070912
  • [Presentation] 低用量のベネディピンは急性自己免疫性心筋炎を改善する2007

    • Author(s)
      岸本千晴, 塩路圭介, 袁祖胎, 北徹
    • Organizer
      第55回日本心臓病学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      20070910-20070912
  • [Presentation] MCI-186(エダラボン)は自己免疫性心筋炎を改善する2007

    • Author(s)
      岸本千晴、岡部孝明、服部美樹、島田佳奈、袁祖胎、塩路圭介
    • Organizer
      第55回日本心臓病学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      20070910-20070912
  • [Presentation] 水泳トレーニングは抗酸化効果により動脈硬化の進展を阻止する2007

    • Author(s)
      島田佳奈, 岸本千晴, 岡部孝明, 村山敏典, 横出正之, 北徹
    • Organizer
      第55回日本心臓病学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      20070910-20070912
  • [Presentation] Immunoglobulin suppresses experimental atherosclerosis via the Fc portion independent of hypercholesterolemia2007

    • Author(s)
      Shimada K, Kishimoto C, Yuan Z, Sano H, Shioji K, Xu Y, Yokode M, Kita T
    • Organizer
      第71回日本循環器学会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20070315-20070317
  • [Presentation] Effects of MCI-186 (edaravone), a novel free radical scavenger, upon experimental atherosclerosis in apolipoprotein E-deficient mice2007

    • Author(s)
      Shimada K, Kishimoto C, Okabe T, Murayama T, Yokode M, Kita T
    • Organizer
      第71回日本循環器学会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20070315-20070317
  • [Presentation] Antibody-mediated infections enhancement via Fc receptors in murine coxsackievirus B3 myocarditis2007

    • Author(s)
      Kishimoto C, Shioji K, Yuan Z
    • Organizer
      第71回日本循環器学会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20070315-20070317
  • [Presentation] An experimental model of in vitro autoimmune-mediated myocardial damage in myocarditis2007

    • Author(s)
      Kishimoto C, Nimata M, Yuan Z
    • Organizer
      第71回日本循環器学会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20070315-20070317
  • [Presentation] NG-nitro-L-arginine methyl ester (L-NAME)の投与は運動による動脈硬化抑制を阻害する2006

    • Author(s)
      島田佳奈, 岸本千晴, 岡部孝明, 村山敏典, 横出正之, 北徹
    • Organizer
      第28回心筋生検研究会
    • Place of Presentation
      高槻
    • Year and Date
      20061124-20061125
  • [Presentation] Systemic oxidative stress is increased in patients with heart failure2006

    • Author(s)
      Kishimoto C, Shioji K, Nimata M, Nakamura H, Yodoi J, Tamaki S, Hashimoto T, Kawai C
    • Organizer
      The American Heart Association's Scientific Sessions 2006
    • Place of Presentation
      Chicago
    • Year and Date
      20061113-20061116
  • [Presentation] Peroxisome proliferation-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis2006

    • Author(s)
      Kishimoto C, Yuan Z, Shioji K
    • Organizer
      The American Heart Association's Scientific Sessions
    • Place of Presentation
      Chicago
    • Year and Date
      20061113-20061116
  • [Presentation] 心筋炎標本サンプルよりのリンパ球培養の試み2006

    • Author(s)
      岸本千晴, 二又正臣, 袁祖貽
    • Organizer
      第54回日本心臓病学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      20060925-20060927
  • [Presentation] 急性心筋炎に対する免疫グロブリン療法:多施設共同研究と血中のサイトカイン分析2006

    • Author(s)
      岸本千晴, 塩路圭介, 橋本哲男, 田巻俊一, 河合忠一, 安田聡, 野々木宏, 李鍾大, 加藤茂, 平光伸也, 森本紳一郎
    • Organizer
      第54回日本心臓病学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      20060925-20060927
  • [Presentation] Systemic oxidative stress is increased in patients with heart failure2006

    • Author(s)
      Kishimoto C, Shioji K, Tamaki S, Hashimoto T
    • Organizer
      第54回日本心臓病学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      20060925-20060927
  • [Presentation] Inflammatory cell infiltrates and edema in the conduction system cause complete AV block in experimental murine myocarditis2006

    • Author(s)
      Kishimoto C, Ohmae M, Tomioka N
    • Organizer
      第54回日本心臓病学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      20060925-20060927
  • [Presentation] Supplementation of L-NAME restores suppressive effects of exercise upon experimental murine atherosclerosis2006

    • Author(s)
      Shimada K, Kishimoto C, Okabe T, Murayama T, Yokode M, Kita T
    • Organizer
      2nd Congress of International Academy of Cardiovascular Sciences
    • Place of Presentation
      Sapporo
    • Year and Date
      20060714-20060716
  • [Presentation] 心房細動を合併した心筋梗塞患者でのジピリダモール負荷心筋シンチ時にみられた興味ある心拍変動について2006

    • Author(s)
      吉田由紀, 岸本千晴, 全栄和, 中村玲雄, 伊藤一貴
    • Organizer
      第101回日本循環器学会近畿地方会
    • Place of Presentation
      神戸
    • Year and Date
      2006-06-24
  • [Book] わかりやすい内科学2008

    • Author(s)
      岸本千晴
    • Total Pages
      202-206
    • Publisher
      文光堂
  • [Book] 心筋炎における酸化ストレス、酸化ストレスVer. 2フリーラジカル医学生物学の最前線(ed by吉川敏一)2006

    • Author(s)
      岸本千晴
    • Total Pages
      275-278
    • Publisher
      医歯薬出版株式会社
  • [Remarks] ホームページ等

    • URL

      http://kyoto-u-cardio.jp/

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Published: 2011-06-18   Modified: 2016-04-21  

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