2007 Fiscal Year Final Research Report Summary
Research of the regulation of adipase mass through angiogenesis induced by the endothelin system
| Project/Area Number |
18590813
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
EMOTO Noriaki Kobe University, Graduate School of Medicine, Assistant Professor (30294218)
|
|---|
| Project Period (FY) |
2006 – 2007
|
| Keywords | Endothelin / Obesity / Angiopenesis |
|---|
| Research Abstract |
Our Specific Aims of the research proposal and Results obtained were as follows:
1. To elucidate the molecular mechanisms of ET-1 produced from endothelial cell in impaired angiogenesis in adipose tissue growth.
Examination of oxygen consumption and respiratory quotient at 8 weeks of age showed no significant differences between WT and KO mice. There were no significant differences in locomotor activity and body temperature assessed by implanted radio frequency telemetry. Food consumption adjusted for mouse weight was not different between WT and KO mice. Vascular density in endothelin-1 deficient mice was decreased as compared to WT mice, indicating that retarded adipose mass growth in KO mice correlated with decreased vascular formation.
2. To examine whether anti-obesity phenotype in ET-1 KO mice leads to the prevention for obesity-related disorders.
We found that mice lacking endothelin-1 in vascular endothelial cells resist the development of diet-induced obesity, hypertension, and insulin resistance.
3. To investigate the possibility whether the endothelin system could be a therapeutic target for obesity and the related disorders.
ET-1 KO mice were mated with mice models of genetic obesity and insulin resistance to produce double mutant mice. We used two different kinds of obesity models, ob/ob and KKAy mice. We demonstrated that endothelin-1 has an important role for inducing inflammation in adipose tissue.
|
Research Products
(16 results)
-
-
-
-
-
[Journal Article] Circadian expression of clock genes in human peripheral leukocytes2007
Author(s)
Fukuya, H, Emoto, N, Nonaka, H, Yagita, K, Okamura, H, Yokoyama, M
-
Journal Title
Biochem Biophys Res Commun 354
Pages: 924-928
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Local overexpression of toll-like receptors at the vessel wall induces atherosclerotic lesion formation: synergism of TLR2 and TLR42007
Author(s)
Shinohara, M, Hirata, K, Yamashita, T, Takaya, T, Sasaki, N, Shiraki, R, Ueyama, T, Emoto, N, Inoue, N, Yokoyama, M, Kawashima, S
-
Journal Title
Arterioscler Thromb Vase Biol 27
Pages: 2384-2391
Description
「研究成果報告書概要(欧文)」より
-
-
[Journal Article] Inhibitory effect of insulin on vasopressin-induced intracellular calcium response is blunted in hyperinsulinemic hypertensive patients: role of membrane fatty acid composition2006
Author(s)
Maekawa, K, Tsujino, T, Saito, K, Kim, JI, Ikeda, Y, Emoto, N, Yokoyama, M
-
Journal Title
Heart Vessels 21
Pages: 205-212
Description
「研究成果報告書概要(欧文)」より
-
-
-
[Presentation] The effects of a dual endothelia receptor antagonist, bosentan, on metabolic parameters in the patients with pulmonary hypertension2007
Author(s)
Iwasa, N., Nakayama, K., Miyagawa, K., Nonaka, H., Emoto, N
Organizer
ET-10: Tenth International Conference on Endothelin
Place of Presentation
Bergamo, Italy
Year and Date
2007-09-16
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
[Presentation] Endothelial Cell-restricted Inactivation of Endothelin-1 revealed its Unexpected Role in the Regulation of Adipose Tissue Mass Accumulation through its Angiogenic Property2006
Author(s)
Adiarto, S., Emoto, N., Iwasa, N., Raharjo, SB., Nakayama, K., Anggrahini, WD., Widyantro, B., Nonaka, H., Masuda, Y., Suzuki, T., Kisanuki, YY, Yanagisawa, M., Yokoyama, M
Organizer
79th the Scientific Sessions of the American Heart Association
Place of Presentation
Chicago, USA
Year and Date
2006-11-12
Description
「研究成果報告書概要(欧文)」より
-
