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2007 Fiscal Year Final Research Report Summary

Studies on rheumatoid lung in murine model

Research Project

Project/Area Number 18590854
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionThe University of Tokushima

Principal Investigator

TANI Kenji  The University of Tokushima, Institute of Health Bioscience, Graduate School, Professor (70207166)

Co-Investigator(Kenkyū-buntansha) OGAWA Hirohisa  The University of Tokushima, Institute of Health Bioscience, Graduate School, COE researcher (50403754)
Project Period (FY) 2006 – 2007
Keywordsrheumatoid arthritis / mouse / interstitial pneumonia / Anthritogenic mAB Cocktail / liponolysaccharide
Research Abstract

An animal model of collagen type II-specific monoclonal antibody-induced arthritis has been used for the evaluation of various therapeutic effects in joint inflammation of rheumatoid arthritis. We aimed to make a model for interstitial pneumonia of rheumatoid arthritis using this arthritis model. A commercially available antibody cocktail containing four monoclonal anti-type II collagen antibodies were injected into 6 to 8-week-old female DBA/1 female mice and 50 uL lipopolysaccharide was injected 3 days later. The clinical manifestations of RA were recorded and scored at 10 days (acute stage) and 21 days (chronic stage). Then the mice were sacrificed for histological analysis of interstitial pneumonia. We found that an animal model for interstitial pneumonia of rheumatoid arthritis was made by repeated injection with the Anthritogenic mAB Cocktail and lipopolysaccharide. A mild edema and slight infiltration of mononuclear cells were found in the alveolar wall treated with the Cocktail in mice in groups treated with 2mg x3 times and 4mg x once. The measurement of collagen amount and specific staining for collagen needs to clarify the fibrotic change in the lung. This model can be useful to investigate the mechanism of interstitial pneumonia due to rheumatoid arthritis and the evaluation of medications for intersititial pneumonia.

  • Research Products

    (14 results)

All 2008 2007 2006 2005 Other

All Journal Article (12 results) (of which Peer Reviewed: 6 results) Presentation (2 results)

  • [Journal Article] Observations on the occurrence of exacerbations in clinical course of systemic lupus erythematosus.2008

    • Author(s)
      Tani K, et. al.
    • Journal Title

      J Med Invest 55

      Pages: 112-119

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Life expectancies of patients with rheumatoid arthritis- a review of deaths over a 20 year period.2008

    • Author(s)
      Tani K, et. al.
    • Journal Title

      Mod Rheumatol 18

      Pages: 165-169

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Life expectancies of patients with rheumatoid Arithritis-A review of deaths over a 20 year period2008

    • Author(s)
      Shinomiya, F., Tani, K., et. al.
    • Journal Title

      Mod Rheumatol 18

      Pages: 165-169

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Observations on the occurrence of exacerbations in clinical course of systemic lupus erythematosus2008

    • Author(s)
      Tomioka, R., et. al.
    • Journal Title

      J Med Invest 55

      Pages: 12-119

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cathepsin G: The significance in rheumatoid arthritis as a monocyte chemoattractant.2007

    • Author(s)
      Tani K, et. al.
    • Journal Title

      Rheumatol Int 27

      Pages: 375-382

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Comparison of clinical course of polymyositis and dermatomyositis: A follow-up study in Tokushima University Hospital.2007

    • Author(s)
      Tani K, et. al.
    • Journal Title

      J Med Invest 54

      Pages: 295-302

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Comparison of clinical course of polymyositis and dermatomyositis : A follow-up study in Tokushima University Hospital2007

    • Author(s)
      Tani, K., et. al.
    • Journal Title

      J Med Invest 54

      Pages: 295-302

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A Novel I kappa B kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice.2006

    • Author(s)
      Tani K, et. al.
    • Journal Title

      Am J Respir Crit Care Med 173

      Pages: 1016-1022

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Defensins- and cathepsin G-ANCA in systemic lupus erythematosus.2006

    • Author(s)
      Tani K, et. al.
    • Journal Title

      Rheumatol Int 27

      Pages: 147-152

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] A Novel I kappa B kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in Mice2006

    • Author(s)
      Inayama, M., et. al.
    • Journal Title

      Am J Respir Crit Care Med 173

      Pages: 1016-1022

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Defensins- and Cathepsin G-ANCA in systemic lupus erythematosus2005

    • Author(s)
      Tamiya, H., et. al.
    • Journal Title

      Rheumatol Int 27

      Pages: 147-152

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cathepsin G : The significance in rheumatoid arthritis as a monocyte chemoattractant

    • Author(s)
      Miyata, J., et. al.
    • Journal Title

      Rheumatol Int 27

      Pages: 375-382

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Aminopeptidase N is a useful marker in pulmonary and pleural involvements of collagen vascular diseases2007

    • Author(s)
      Tani, K., et. al.
    • Organizer
      69th American College of Rheumatology
    • Place of Presentation
      Boston, USA
    • Year and Date
      20070000
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Aminopeptidase N is a useful marker in pulmonary and pleural involvements of collagen vascular diseases2007

    • Author(s)
      Tani K, et. al.
    • Organizer
      69th American College of Rheumatology
    • Place of Presentation
      Boston, U.S.A
    • Year and Date
      2007-11-16
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-02-04  

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