Cross talk between the onset of renal osteodystrophy and ectopic vascular calcification

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 18590909
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Showa University
• Principal Investigator: AKIZAWA Tadao Showa University, School of Medicine, Professor (40102339)
• Co-Investigator(Kenkyū-buntansha): OGATA Hiroaki Showa University, School of Medicine, Assistant Professor (30296959) ; SHIIZKI Kazuhiro Wakayama Medical University, 医学部, Assistant Professor (10423930)
• Project Period (FY): 2006 – 2007
• Keywords: Renal osteodystrophy / Secondary hyperparathyroidism / Ectopic vascular calcification / Phosphorus / Vitamin D / Calcium / Parathyroid hormone / Osteitis fibrosa

Research Abstract

Representative outcomes of disturbed Ca and phosphate metabolism are renal osteodystrophy, secondary hyperparathyroidism and ectopic vascular calcification. These abnormalities result in systemic pathological changes in dialysis patients, and shorten the survival or deteriorate the health related quality of life. To understand the mechanisms to progress these systemic abnormalities, cross-talk between renal osteodystrophy, secondary hyperparathyroidism and ectopic vascular calcification was investigated. In uremic rats that develop severe secondary hyperparathyroidism with vascular calcification, advanced osteitis fibrosa has been developed, and the strong association among these progressions was observed. By the intervention of direct injection of vitamin D into hyperplastic parathyroid grand recovered the hyperplasia of parathyroid grand as well as the osteitis fibrosa. However this intervention failed to decrease the ectopic vascular calcification. These results suggest that the presence of cross talk in the developing stage between renal osteodystrophy, secondary hyperparathyroidism and ectopic vascular calcification, but this cross talk disappear at the regression process. The precise process of the cross talk should be further evaluated.

Research Products

• [Journal Article] Highly Concentrated Calcitriol and its Analogues Induce Apoptosis of Parathyroid Cells and Regression of the Hyperplastic Gland Study in Rats (2008)
  • Author(s): Shiizaki K, Hatamura I, Negi S, Sakaguchi T, Saji F, Imazeki I, Kusano E, Shigematsu T, Akizawa T.
  • Journal Title: Nephrol Dial Transplant 23(5) Pages: 1529-1536
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Direct injection of calcitriol or its analog improves abnormal gene expression in the hyperplastic parathyroid gland in uremia (2008)
  • Author(s): Shiizaki K, Fukagawa M, Yuan Q, Hatamura I, Nii-Kono T, Saji F, Shigematsu T, Akizawa T.
  • Journal Title: Am J Nephrol. 28(1) Pages: 59-66
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Highly Concentrated Calcitriol and its Analogues Induce Apoptosis of Parathyroid Cells and Regression of the Hyperplastic Gland Study in Rats (2008)
  • Author(s): Shiizaki, K., Hatamura, I., Negi, S., Sakaguchi, T., Saji, F., Imazeki, I., Kusano, E., Shigematsu, T., Akizawa, T
  • Journal Title: Nephrol Dial Transplant 23(5) Pages: 1529-36
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Direct injection of calcitriol or its analog improves abnormal gene expression in the hyperplastic parathyroid gland in uremia (2008)
  • Author(s): Shiizaki, K., Fukagawa, M., Yuan, Q., Hatamura, I., Nii-Kono, T., Saji, F., Shigematsu, T., Akizawa, T
  • Journal Title: Am J Nephrol 28(1) Pages: 59-66
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Activation of calcium-sensing receptor accelerates apoptosis in hyperplastic parathyroid cells (2007)
  • Author(s): Mizobuchi M, Ogata H, Hatamura I, Saji F, Koiwa F, Kinugasa E, Koshikawa S, Akizawa T
  • Journal Title: Biochem Biophys Res Commun. 12;362(1) Pages: 11-16
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Combination therapy with an angiotensin-converting enzyme inhibitor and a vitamin D analog suppresses the progression of renal insufficiency in uremic rats (2007)
  • Author(s): Mizobuchi M, Morrissey J, Finch JL, Martin DR, Liapis H, Akizawa T,
  • Journal Title: J Am Soc Nephrol. 18(6) Pages: 1796-1806
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Binding of highly concentrated maxacalcitol to the nuclear vitamin D receptors of parathyroid cells (2007)
  • Author(s): Shiizaki K, Hayakawa N, Imazeki I, Hatamura I, Okada T, Negi S, Sakaguchi T, Shigematsu T, Akizawa T.
  • Journal Title: Nephrol Dial Transplant. 22(4) Pages: 1078-1086
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Activation of calcium-sensing receptor accelerates apoptosis in hyperplastic parathyroid cells (2007)
  • Author(s): Mizobuchi, M., Ogata, H., Hatamura, I., Saji, F., Koiwa, F., Kinugasa, E., Koshikawa, S., Akizawa, T
  • Journal Title: Biochem Biophys Res Commun 362(1) Pages: 11-6
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Combination therapy with an angiotensin-converting enzyme inhibitor and a vitamin D analog suppresses the progression of renal insufficiency in uremic rats (2007)
  • Author(s): Mizobuchi, M., Morrissey, J., Finch, JL., Martin, DR., Liapis, H., Akizawa, T. Slatopoisky, E
  • Journal Title: J Am Soc Nephrol 18(6) Pages: 1796-806
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Binding of highly concentrated maxacalcitol to the nuclear vitamin D receptors of parathyroid cells (2007)
  • Author(s): Shiizaki, K., Hayakawa, N., Imazeki, I., Hatamura, I., Okada, T., Negi, S., Sakaguchi, T., Shigematsu, T., Akizawa, T
  • Journal Title: Nephrol Dial Transplant 22(4) Pages: 1078-86
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Direct maxacalcitol injection into hyperplastic parathyroids improves skeletal changes in secondary hyperparathyroidism (2006)
  • Author(s): Shiizaki K, Hatamura I, Negi S, Sakaguchi T, Saji F, Kunimoto K, Okamoto M, Imazeki I, Muragaki Y, Akizawa T
  • Journal Title: Kidney Int.2006 70(3) Pages: 486-495
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Up-regulation of Cbfa 1 and Pit-1 in calcified artery of uraemic rats with severe hyperphosphataemia and secondary hyperparathyroidism (2006)
  • Author(s): Mizobuchi M, Ogata H, Hatamura I, Koiwa F, Saji F, Shiizaki K, Negi S, Kinugasa E, Ooshima A, Koshikawa S, Akizawa T.
  • Journal Title: Nephrol Dial Transplant. 21(4) Pages: 911-916
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Direct maxacalcitol injection into hyperplastic parathyroids improves skeletal changes in secondary hyperparathyroidism (2006)
  • Author(s): Shiizaki, K., Hatamura, I., Negi, S., Sakaguchi, T., Saji, F., Kunimoto, K., Okamoto, M., Imazeki, I., Muragaki, Y., Akizawa, T
  • Journal Title: Kidney Int 70(3) Pages: 486-95
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Up-regulation of Cbfal and Pit-1 in calcified artery of uraemic rats with severe hyperphosphataemia and secondary hyperparathyroidism (2006)
  • Author(s): Mizobuchi, M., Ogata, H., Hatamura, I., Koiwa, F., Saji, F., Shiizaki, K., Negi, S., Kinugasa, E., Ooshima, A., Koshikawa, S., Akizawa, T
  • Journal Title: Nephrol Dial Transplant 21(4) Pages: 911-6
  • Description: 「研究成果報告書概要(欧文)」より