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2008 Fiscal Year Final Research Report

A study of the cystogenesis in the AQP11 knockout mouse kidney

Research Project

  • PDF
Project/Area Number 18590919
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionClinical research Center, Chiba-East National Hospital, National Hospital Organization

Principal Investigator

小林 克樹  Clinical research Center, Chiba-East National Hospital, National Hospital Organization, 千葉東病院臨床研究センター, 室長 (40415451)

Project Period (FY) 2006 – 2008
Keywords多発性蓑胞腎 / 小胞体ストレス / primary cilia / mTOR / ラパマイシン / アクアポリン
Research Abstract

マウスにおいてAQP11の欠損は、腎臓の近位尿細管上皮細胞に小胞体ストレスを惹起しその結果空胞形成を伴うアポトーシスが誘導されること、しかし皮膚深層の近位尿細管上皮細胞はこの変化は受けずにかえってmTOR情報伝達系の活性化による細胞増殖が亢進し蓑胞を形成することが判明した。
さらに、上記の変化にはprimary ciliaの直接の関与はないと考えられた。

  • Research Products

    (7 results)

All 2008 2007 2006

All Presentation (7 results)

  • [Presentation] The Primary Cilia of The AQP11 Knockout Mouse Kidney2008

    • Author(s)
      Kobayashi K, Uchida S, Sasaki S
    • Organizer
      Renal Week
    • Place of Presentation
      Philadelphia, PA
    • Year and Date
      20081104-9
  • [Presentation] Neonatal Kidneys of AQP11-Disprupted Mice Exhibit ER Stress-Induced Apoptosis of the Proximal Tubules Followed by Repamycin Treatment(F-P0013)2007

    • Author(s)
      Katsuki Kobayashi, Kenichi Ishibashi, Sei Sasaki
    • Organizer
      ASN Renal Week
    • Place of Presentation
      Moscone Center Francisco, California
    • Year and Date
      20071031-20071105
  • [Presentation] Neonatal Kidneys of AQP11-Disrupted Mice Exhibit Enhanced Apoptosis Followed by a Remarkable Slowing of Cyst-formation by Rapamycin Treatment2007

    • Author(s)
      Nara Katsuki Kobayashi Kenichi Ishibashi and Sei Sasaki
    • Organizer
      The 5~<the> International Conference of Aquaporin
    • Place of Presentation
      Nara Centennial Hall
    • Year and Date
      20070713-16
  • [Presentation] AQP11ノックアウトマウスののう胞形成におけるアポトーシスの役割(0-257)2007

    • Author(s)
      小林克樹、石橋賢一、佐々木成
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      20070525-27
  • [Presentation] Proximal tubule cyst formation of AQP11 knockout mice: roles of apoptosis and mTOR signaling pathway(SA-P0968)2006

    • Author(s)
      Katsuki Kobayashi et al
    • Organizer
      ASN Renal Week 2006
    • Place of Presentation
      San Diego Convention Center
    • Year and Date
      20061116-19
  • [Presentation] APQ11ノックアウトマウスのう胞腎形成における細胞増殖・アポトーシスの検討2006

    • Author(s)
      小林克樹
    • Organizer
      日本腎臓学会 第49回日本腎臓学会学術総会 P164
    • Place of Presentation
      東京
    • Year and Date
      20060000
  • [Presentation] rapamycinはAQP11ノックアウトマウスにおいても蓑胞形成を抑制する2006

    • Author(s)
      小林克樹、祭原幸子、石橋賢一
    • Organizer
      第14回蓑胞性腎疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2006-09-09

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Published: 2010-06-10   Modified: 2016-04-21  

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