2007 Fiscal Year Final Research Report Summary
A study for molecular mechanism of familial migraine headache and its model with primary neural and astrocytes culture
| Project/Area Number |
18590941
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Tottori University |
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Principal Investigator |
TAKESHIMA Takao Tottori University, Faculty of Medicine, Associate Professor (20206973)
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| Co-Investigator(Kenkyū-buntansha) |
NAKASO Kazuhiro Tottori University, Factity of Medicine, Research Associate (30379648)
IMAMURA Keiko Tottori University, University Hospital, Senior Resident (90379652)
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| Project Period (FY) |
2006 – 2007
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| Keywords | astrocyte / migraine / glia / MMP-9 / CSD / comorbidity |
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| Research Abstract |
The migraine headache repeats severe headache and nausea, vomiting, photophobia, phonophobia. Migraine inhibits their quality of life. Approximately 8.4 million people suffer migraine headache in our country. Cortical spreading depression (CSD) and neurogenic inflammation have been hypothesized to be key steps in the development of migraine headache. Recent studies have highlighted matrix metalloproteinase-9 (MMP-9) in cortical spreading depression, neurogenic inflammation, and cerebral ischemia. To seek their possible association, we investigated plasma MMP-9 levels in migraineurs during headache-free periods.
The MMP-9 levels in migraineurs were significantly higher than those in controls.
The degradation of extracellular matrix showing the increase of MMP-9 in migrainurs may be associated with an abnormality in their blood vessel permeability. Substance P (SP), calcitonin gene-related peptide (CGRP), and angiotensin converting enzyme (ACE) may have roles in trigeminovascular nociceptive mechanisms. We investigated interictal levels of SP, CGRP, ACE activity. SP and CGRP levels in migraine were significantly higher than in controls. ACE activities in migraine with aura were significantly higher than in controls. The data suggest that SP, CGRP, and ACE are relevant to migraine pathophysiology.
We investigated comorbidity of 103 migraineurs. There were comorbid disordes including allergic rhinitis (21%), hypertensive diseases (12%), asthma (12%), depression (11%), panic disorder (6%), epileptic (1%). As for the asthma or depression, the shared clinical pathophysiology, i.e. an inflammatory mechanism, or serotonin metabolic derangements can be estimated.
MPP-9 and CGRP play some significant role in'migraine pathophysiology. Further studies of MMPs are necessary to elucidate their role.
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[Journal Article] Increased plasma substance P and CGRP levels, and high ACE activity in migraineurs during headache-free periods2007
Author(s)
Fusayasu, E, Kowa, H, Takeshima, T, Nakaso, K, Nakashima, K
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Pramipexole protects dopaminergic neurons from lactacystin-induced cell death in rat primary mesencephalic culture2007
Author(s)
Imamura, K, Takeshima, T, Nakaso, K, Ito, S, Nakashima, K
Organizer
Society for Neuroscience
Place of Presentation
San Diego, CA
Year and Date
20070000
Description
「研究成果報告書概要(欧文)」より
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[Presentation] D-β-hydroxybutirate (bHB) attenuated the rotenone-induced mitochondrial impairment in a model of differentiated SH-SY5Y cell2006
Author(s)
Takeshima, T, Imamura, K, Kashiwaya, Y, Nakaso, K, Nakashima, K
Organizer
Socsiety for Neuroscience
Place of Presentation
Atlanta, Georgia
Year and Date
20060000
Description
「研究成果報告書概要(欧文)」より
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