2007 Fiscal Year Final Research Report Summary
Mechanisms of neurodegeneration in an animal model of tauopathies
| Project/Area Number |
18590942
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Okayama University |
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Principal Investigator |
ISHIHARA Takeshi Okayama University, Hospital, Neuropsychiatry, Lecturer (60335594)
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| Project Period (FY) |
2006 – 2007
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| Keywords | tau / tauopathies / neurodegeneration / calpain-calpastatin pathway / mouse models / Alzheimer's disease |
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| Research Abstract |
Tau transgenic mice (PrP T44) were crossbred with calpastatin knock-out mice (CS-KO) to investigate the influence of calpain-calpastatin pathway on neurodegeneration related to tau overexpression. Deletion of calpastatin in PrP T44 mice resulted in acceleration of behavioral symptoms and pathological and biochemical changes, indicating that calpain-calpastatin pathway is involved in the neurodegeneration induced by tau overexpression in the central nervous system in mice. The underlying mechanisms of the findings in this study remain to be elucidated by further investigations.
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