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2007 Fiscal Year Final Research Report Summary

Role of intercellular electrical coupling in neurological disorders : elucidation of gap junction funciotn

Research Project

Project/Area Number 18590962
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

TSUJI Sadatosi  University of Occupational and Environmental Health, Japan, School of Medicine, Professor (30117171)

Co-Investigator(Kenkyū-buntansha) TAKENORI Uozumi  University of Occupational&Environmental Health, Japan, School of Medicine, Associate Professor (00160226)
AKAMATSU Naoki  University of Occupational&Environmental Health, Japan, School of Medicine, Assistant Professor (10299612)
YUHI Tomoaki  University of Occupational&Environmental Health, Japan, School of Medicine, Research Associate (60330982)
OKADA Kazumasa  University of Occupational&Environmental Health, Japan, School of Medicine, Research Associate (30341499)
Project Period (FY) 2006 – 2007
Keywordsgap junction / connexin / very fast oscillation / EL mouse / epilepsy / ELマウス
Research Abstract

We investigated the effect of the gap junction blocks; carbenoxolone (100mM) on epileptiform bursting induced by bicuculline (GABAA receptor blocker), 0-Me^<2+> and high KE (9.25m) in genetically epileptic EL mouse hippocampal slices. Carbenoxolone abolished bicuculline and high-K^+-induced epileptiform activities completely and decreased the frequency of 0- Mg^<2+>induced epileptiform bursts.
These results were almost same as previously reported in normal mice and rats. We conclude that gap junction contrlute to the prolongation of epileptiform discharges in EL mouse just as in normal mouse.
In patients with subdural electrodes implanted for the treatment of medically intractable epilepsy, we investigated the inter-cortical connection of the epileptogenic regions. The cortical electroencephalographic recording revealed that the epileptogenic network consists of independent epileptogenic areas. The strength of the interepileptogenic area connectivities were different on each connection. The gap junction may play a role in the interareal neuronal connectivity.

  • Research Products

    (6 results)

All 2007

All Journal Article (5 results) Book (1 results)

  • [Journal Article] 神経疾患治療ノートてんかん2007

    • Author(s)
      辻 貞俊, 赤松 直樹
    • Journal Title

      Clinical Neuroscience 25

      Pages: 476-477

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 電気刺激によるてんかん治療2007

    • Author(s)
      辻 貞俊, 赤松 直樹
    • Journal Title

      日本医師会雑誌 136

      Pages: 1098-1098

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The treatment of epilepsy2007

    • Author(s)
      Tsuji, S., Akamatsu, N.
    • Journal Title

      Clinical neuroscience 25

      Pages: 476-477

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The treatment of epilepsy by electrical stimulation2007

    • Author(s)
      Tsuji, S., Akamatsu, N.
    • Journal Title

      The Journal of the Japan Medical Association 136(6)

      Pages: 1098

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Symptomatic epilepsy2007

    • Author(s)
      Tsuji, S
    • Journal Title

      Today's Therapy

      Pages: 633-634

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 2007 Today's Therapy 今日の治療指針 私はこう治療している2007

    • Author(s)
      辻 貞俊
    • Total Pages
      2
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-02-04  

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