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2007 Fiscal Year Final Research Report Summary

The predictive or monitoring marker for Alzheimer's disease

Research Project

Project/Area Number 18590968
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionNational Institute for Longevity Sciences,NCGG

Principal Investigator

MATSUBARA Etsuo  National Institute for Longevity Sciences,NCGG, National Center for Geriatrics and Gerontology, 室長 (70219468)

Co-Investigator(Kenkyū-buntansha) SHOJI Mikio  Hirosaki University, Graduate School of Medicine, Professor (60171021)
ITO Nobuo  Mie University, Graduate School of Medicine, Instructor (10362344)
KAWARABAYASHI Takeshi  Hirosaki University, Graduate School of Medicine, Assistant Professor (90186156)
Project Period (FY) 2006 – 2007
KeywordsAlzheimer's disease / ELISA / Aβ oligomers / marker
Research Abstract

In the present research, we have developed a sandwich ELISA specific to Aβ oligomers. The combination of this methodology with size exclusion chromatography allowed us to identify the presence of Aβ oligomers in human cerebrospinal fluid(CSF). It is well known that the levels of Aβ monomers was decreased in the CSF obtained from Alzheimer's disease(AD) compared to age-matched normal subjects. Interestingly, the levels of Aβ oligomers were increased in AD patients with a comcomitant reduction of Aβ monomers. Therefore, it is relevant to note that the measurement of the ratio, Aβ oligomers to monomers, was a potential tool to monitor the Alzheimer's disease. We also found that the administration of melatonin caused the elevation of Aβ in plasma obtained from the model mice of Alzheimer's disease, whch allowed us to see if which mice have an accumulation of Aβ in the brain. Our results may indicate that both could be a potential "surrogate marker" for AD.

  • Research Products

    (27 results)

All 2008 2007 2006

All Journal Article (24 results) (of which Peer Reviewed: 3 results) Presentation (1 results) Book (2 results)

  • [Journal Article] Plasma antibodies to Abeta40 and Abeta42 in patients with Alzheimer's disease and normal controls.2008

    • Author(s)
      Xu W, Matsubara E, et. al.
    • Journal Title

      Brain Res (Epub ahead of print)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Transthyretin Accelerates Vascular Abeta Deposition in a Mouse Model ol Alzheimer's Disease.2008

    • Author(s)
      Wati H, Kawarabayashi T, Matsubara E, Kasai A, Hirasawa T, Kubota T, Harigaya Y, Shoji M, Maeda S.
    • Journal Title

      Brain Pathol 2008 Apr 22 (Epub ahead of print)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Microglial activation in brain lesions with tau deposits : Comparison ot human tauopathies and tau transgenic mice TgTau(P301L).2008

    • Author(s)
      Sasaki A, Kawarabayashi T, Murakami T, Matsubara E, Ikeda M, Hagiwara H, Westaway D, George-Hyslop PS, Shoji M, Nakazato Y.
    • Journal Title

      Brain Res. 1214

      Pages: 159-68

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Plasma antibodies to Abeta40 and Abeta42 in patients with Alzheimer's disease and normal controls.2008

    • Author(s)
      Xu W, Kawarabayashi T, Matsubara E, Deguchi K, Murakami T, Harigaya Y, Ikeda M, Amari M, Kuwano R, Abe K, Shoji M.
    • Journal Title

      Brain Res (Epub ahead of print)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] アルツハイマー病-基礎研究から予防・治療への新しいパラダイム- II基礎編 アルツハイマー病に関する基礎知識, Aβ化学構造の分解過程, Aβの化学構造.2008

    • Author(s)
      松原悦朗, 柳澤勝彦.
    • Journal Title

      日本臨床(日本臨床社, 大阪) 66巻増刊号1

      Pages: 61-66

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] アルツハイマー病-基礎研究から予防・治療への新しいパラダイム- III臨床編 アルツハイマー病の診断, 生物学的マーカー検査 脳脊髄液 タウ.2008

    • Author(s)
      松原悦朗.
    • Journal Title

      日本臨床(日本臨床社, 大阪) 66巻増刊号1

      Pages: 247-251

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] アルツハイマー病-基礎研究から予防・治療への新しいパラダイム- III臨床編 アルツハイマー病の新しい治療法の開発 新規医薬品 Aβ凝集抑制薬.2008

    • Author(s)
      松原悦朗, 柳澤勝彦.
    • Journal Title

      日本臨床(日本臨床社, 大阪) 66巻増刊号1

      Pages: 493-497

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] アルツハイマー病-基礎研究から予防・治療への新しいパラダイム- III臨床編 アルツハイマー病の新しい治療法の開発 Aβクリアランス経路を標的とした治療法の開発.2008

    • Author(s)
      松原悦朗.
    • Journal Title

      日本臨床(日本臨床社, 大阪) 66巻増刊号1

      Pages: 542-546

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] アルツハイマー病の最近の進歩 : アルツハイマー病の抗体治療2008

    • Author(s)
      松原悦朗.
    • Journal Title

      臨床検査 52(3)

      Pages: 297-301

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The Japanese Genetic Study Consortium for Alzheimer's Disease,Consortium Information:Members are listed in the acknowledgements.Genetic association of CTNNA3 with late-onset Alzheimer's disease in females.2007

    • Author(s)
      Miyashita A, Matsubara E, et. al.
    • Journal Title

      Hum Mol Genet 16

      Pages: 2854-2869

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] A ganglioside-induced toxic soluble Abeta assembly.Its enhanced formation from Abeta bearing the Arctic mutation.2007

    • Author(s)
      Yamamoto N, Matsubara E, et. al.
    • Journal Title

      J Biol Chem 282

      Pages: 2646-2655

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] The Japanese Genetic Study Consortium for Alzheimer's Disease, Consortium Information : Members are listed in the acknowledgements. Genetic association of CTNNA3 with late-onset Alzheimer's disease in females.2007

    • Author(s)
      Miyashita A, Arai H, Asada T, Imagawa M, Matsubara E, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R
    • Journal Title

      Hum Mol Genet 16

      Pages: 2854-2869

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A unique case of limb-girdle muscular dystrophy type 2A carrying novel compound heterozygous mutations in the human CAPN3 gene.2007

    • Author(s)
      Matsubara E, Tsuchiya A, Minami N, Nishino I, Pappolla MA, Shoji M, Abe K.
    • Journal Title

      Eur J Neurol 14

      Pages: 819-822

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A ganghliside-induced toxic soluble Abeta assembly. Its enhanced formation from Abeta bearing the Arctic mutation.2007

    • Author(s)
      Yamamoto N, Matsubara E, Maeda S, Minagawa H, Takashima A, Murayama W, Michikawa M, Yanagisawa K
    • Journal Title

      J Biol Chem 282(4)

      Pages: 2646-2655

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Enhanced accumulation of phosphorylated alpha-synuclein double transgenic mice expressing mutant beta-amyloid precursor protein and presenilin-1.2007

    • Author(s)
      Kurata T, Kawarabayashi T, Murakami T, Miyazaki K, Morimoto N, Ohta Y, Takehisa Y, Nagai M, Ikeda M, Matsubara E, Westaway D, Hyslop PS, Harigaya Y, Kamiya T, Shoji M, Abe K.
    • Journal Title

      J Neurosci Res. 85(10)

      Pages: 2246-52

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] PINK1, a gene product of PARK6, accumulates in {alpha}-synucleinopathy brains.2007

    • Author(s)
      Murakami T, Moriwaki Y, Kawarabayashi T, Nagai M, Ohta Y, Deguchi K, Kurata T, Takehisa Y, Matsubara E, Ikeda M, Harigaya Y, Shoji M, Takahashi R, Abe K.
    • Journal Title

      J Neurol Neurosurg Psychiatry. 78(6)

      Pages: 653-4

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Aβオリゴマー2007

    • Author(s)
      松原悦朗.
    • Journal Title

      Dementia Japan 21

      Pages: 253-260

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] アルツハイマー病モデル動物におけるメラトニン療法2007

    • Author(s)
      松原悦朗.
    • Journal Title

      Modern Physician 27(8)

      Pages: 1105-1108

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] トランスジェニックマウスを用いたアルツハイマー病発症機序の解析2007

    • Author(s)
      瓦林毅, 針谷康夫, 池田将樹, 岡本幸市, 東海林幹夫, 松原悦朗.
    • Journal Title

      老年期痴呆研究会誌 14

      Pages: 9-11

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] アルツハイマー病動物モデルによる治療法開発2007

    • Author(s)
      松原悦朗.
    • Journal Title

      老年期痴呆研究会誌 14

      Pages: 159-160

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cortical neuronal and glial pathology in TgTauP301L transgenic mice : neuronal degeneration, memory disturbance, and phenotypic variation.2006

    • Author(s)
      Murakami T, Paitel E, Kawarabayashi T, Ikeda M, Chishti MA, Janus C, Matsubara E, Sasaki A, Kawarai T, Phinney AL, Harigaya Y, Home P, Egashira N, Mishima K, Hanna A, Yang J, Iwasaki K, Takahashi M, Fujiwara M, Ishiguro K, Bergeron C, Carlson GA, Abe K, Westaway D, St George-Hyslop P, Shoji M
    • Journal Title

      Am J Pathol 169(4)

      Pages: 1365-1375

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Enhanced accumulation of tau in double transgenic mice expressing mutant beta APP and presenilin-1.2006

    • Author(s)
      Samura E, Shoji M, Kawarabayashi T, Sasaki A, Matsubara E, Murakami T, Wuhua X, Tamura S, Ikeda M, Ishiguro K, Saido TC, Westaway D, St George Hyslop P, Harigaya Y, Abe K
    • Journal Title

      Brain Res 1094(1)

      Pages: 192-199

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Type-specific evolution of amyloid plaque and angiopathy in APPsw mice.2006

    • Author(s)
      Harigaya Y, Tomidokoro Y, Ikeda M, Sasaki A, Kawarabayashi T, Matsubara E, Kanai M, Saido TC, Younkin SG, Shoji M.
    • Journal Title

      Neurosci Lett 395(1)

      Pages: 37-41

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 老年期認知症ナビゲーター 第7章 生理・病理2006

    • Author(s)
      松原悦朗, 柳澤勝彦.
    • Journal Title

      老人斑,βアミロイド前駆体蛋白(APP)とβアミロイド (メディカルレビュー社)

      Pages: 212-213, 216-217

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] アルツハイマー病におけるAβオリゴマー特異的受動免疫療法.2008

    • Author(s)
      松原 悦朗
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 図説 分子病態学 4版(一瀬白帝, 鈴木宏治 編 著)2008

    • Author(s)
      松原悦朗, 柳澤勝彦
    • Total Pages
      5
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 老年期認知症ナビゲーター 第7章 生理・病理2006

    • Author(s)
      松原悦朗, 柳澤勝彦.
    • Publisher
      メディカルレビュー社
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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